[en] Although it has been well established that GH treatment increases final height (FH) in girls with Turner syndrome (TS), the optimal ages to start GH therapy and introduce estrogens for pubertal induction have not been defined. We evaluated retrospectively the influence of the age at onset of GH treatment and age at onset of puberty on FH of 186 adult TS women treated during childhood with GH. Puberty started spontaneously in 38 patients, and it was induced in 148 girls with ethinyl estradiol ( mean +/- SD starting dose, 66 =/- 32 ng/ kg . d). Patients with spontaneous or induced puberty were divided into quartiles on the basis of age at initiation of GH treatment ( 3 - 10, 10 - 12, 12 - 14, and 14 - 19 yr). FH was 151.7 +/- 6.0 cm; there were no FH differences between patients with induced or spontaneous puberty, nor were there differences between the age quartiles. Puberty started earlier in the girls with spontaneous puberty than in those with induced puberty ( 12.4 +/- 1.3 yr vs. 14.5 +/- 1.9 yr; P < 0.0001). The age at onset of puberty was not related to FH. Pubertal growth was 15.4 +/- 4.6 cm in the girls with spontaneous puberty and 8.6 +/- 4.3 cm in the girls with induced puberty ( P< 0.0001). We conclude that GH treatment results in a significant increase in FH in most TS girls. Under the conditions of GH treatment and induction of puberty that we have used, the age at start of GH treatment was not related to FH; in addition, late or delayed induced or spontaneous puberty did not affect FH.
Disciplines :
Endocrinology, metabolism & nutrition
Author, co-author :
Massa, G.
Heinrichs, C.
Verlinde, S.
Thomas, M.
Bourguignon, Jean-Pierre ; Université de Liège - ULiège > Département des sciences cliniques > Pédiatrie
Craen, M.
Francois, I.
Du Caju, M.
Maes, M.
De Schepper, J.
Language :
English
Title :
Late or delayed induced or spontaneous puberty in girls with Turner syndrome treated with growth hormone does not affect final height
Publication date :
2003
Journal title :
Journal of Clinical Endocrinology and Metabolism
ISSN :
0021-972X
eISSN :
1945-7197
Publisher :
Oxford University Press, New York, United States - New York
Volume :
88
Issue :
9
Pages :
4168-4174
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
The Foundation of the Belgian Study Group for Pediatric Endocrinology
scite shows how a scientific paper has been cited by providing the context of the citation, a classification describing whether it supports, mentions, or contrasts the cited claim, and a label indicating in which section the citation was made.
Bibliography
Ranke MB, Saenger P 2001 Turner's syndrome. Lancet 358:309-314
Bramswig 2001 Long-term results of growth hormone therapy in Turner syndrome. Endocrine 15:5-13
Rosenfeld RG, Frane J, Attie KM, Brasel JA, Burstein S, Cara JF, Chernausek S, Gotlin RW, Kuntze J, Lippe BM, Mahoney PC, Moore WV, Saenger P, Johanson AJ 1992 Six-year results of a randomized, prospective trial of human growth hormone and oxandrolone in Turner syndrome. J Pediatr 121:49-55
Vanderschueren-Lodeweyckx M, Massa G, Maes M, Craen M, van Vliet G, Heinrichs C, Malvaux P 1990 Growth promoting effect of growth hormone and low dose. J Clin Endocrinol Metab 70:122-126
De Schepper J, Craen M, Massa G, Heinrichs C, Maes M, Du Caju M, Rausin L, Bourguignon JP 1994 Growth hormone therapy in Turner's syndrome: one versus two daily injections. J Clin Endocrinol Metab 79:489-494
Hochberg Z, Zadik Z 1999 Final height in young women with Turner syndrome after GH therapy: an open controlled study. Eur J Endocrinol 141:218-224
Schweizer R, Ranke MB, Binder G, Herdach F, Zapadlo M, Grauer ML, Schwarze CP, Wollmann HA 2000 Experience with growth hormone therapy in Turner syndrome in a single centre: low total height gain, no further gains after puberty onset and unchanged body proportions. Horm Res 53:228-238
Johnston DI, Betts P, Dunger D, Barnes N, Swift PG, Buckler JM, Butler GE 2001 A multicentre trial of recombinant growth hormone and low dose oestrogen in Turner syndrome: near final height analysis. Arch Dis Child 84:76-81
Nilsson KO, Albertsson-Wikland K, Alm J, Aronson S, Gustafsson J, Hagenas L, Hager A, Ivarsson SA, Karlberg J, Kristrom B, Marcus C, Moell C, Ritzen M, Tuvemo T, Wattsgard C, Westgren U, Westphal O, Aman J 1996 Improved final height in girls with Turner's syndrome treated with growth hormone and oxandrolone. J Clin Endocrinol Metab 81:635-640
Rosenfeld RG, Attie KM, Frane J, Brasel JA, Burstein S, Cara JF, Chernausek S, Gotlin RW, Kuntze J, Lippe BM, Mahoney CP, Moore WV, Saenger P, Johanson AJ 1998 Growth hormone therapy of Turner's syndrome: beneficial effect on adult height. J Pediatr 132:319-324
Cacciari E, Mazzanti L, and the Italian Study Group for Turner Syndrome 1999 Final height of patients with Turner's syndrome treated with growth hormone (GH): indications for GH therapy alone at high doses and late estrogen therapy. J Clin Endocrinol Metab 84:4510-4515
Reiter EO, Blethen SL, Baptista J, Price L 2001 Early initiation of growth hormone treatment allows age-appropriate estrogen use in Turner's syndrome. J Clin Endocrinol Metab 86:1936-1941
Nilsson KO, for the Swedish Study Group of Growth Hormone Treatment 2000 Timing of oestrogen therapy in girls with Turner syndrome: the Swedish experiences and a review. In: Saenger P, Pasquino AM, eds. Optimizing health care for Turner patients in the 21st century. Amsterdam: Elsevier Science BV; 185-197
Chernausek SD, Attie KM, Cara JF, Rosenfeld RG, Frane J, and the Genentech, Inc., Collaborative Study Group 2000 Growth hormone therapy of Turner syndrome: the impact of age of estrogen replacement on final height. J Clin Endocrinol Metab 85:2439-2445
Quigley CA, Crowe BJ, Anglin DG, Chipman JJ, and the US Turner Syndrome Study Group 2002 Growth hormone and low dose estrogen in Turner syndrome: results of a United States multi-center trial to near-final height. J Clin Endocrinol Metab 87:2033-2041
Stahnke N, Keller E, Landy H, and the Serono Study Group 2002 Favorable final height outcome in girls with Ullrich-Turner syndrome treated with low-dose growth hormone together with oxandrolone despite starting treatment after 10 years of age. J Pediatr Endocrinol Metab 15:129-138
Carel J-C, Mathivon L, Gendrel C, Ducret J-P, Chaussain J-L 1998 Near normalization of final height with adapted doses of growth hormone in Turner's syndrome. J Clin Endocrinol Metab 83:1462-1466
Van Pareren YK, de Muinck Keizer-Schrama SM, Stijnen T, Sas TCJ, Jansen M, Otten BJ, Hoorweg-Nijman JJ, Vulsma T, Stokvis-Brantsma WH, Rouwe CW, Reeser HM, Gerver WJ, Gosen JJ, Rongen-Westerlaken C, Drop SL 2003 Final height in girls with Turner syndrome after long-term growth hormone treatment in three dosages and low dose estrogens. J Clin Endocrinol Metab 88:1119-1125
Massa G, Vanderschueren-Lodeweyckx M, Malvaux P 1990 Linear growth in patients with Turner syndrome: influence of spontaneous puberty and parental height. Eur J Pediatr 149:246-250
Grumbach MM 2000 Estrogen, bone, growth and sex: a sea change in conventional wisdom. J Pediatr Endocrinol Metab 13(Suppl 6):1439-1455
Ross JL, McCauley E, Roeltgen D, Long L, Kushner H, Feuillan P, Cutler Jr GB 1996 Self-concept and behavior in adolescent girls with Turner syndrome: potential estrogen effects. J Clin Endocrinol Metab 81:926-931
Carrascosa A, Gussinye M, Terradas P, Yeste D, Audi L, Vicens-Calvet E 2000 Spontaneous, but not induced, puberty permits adequate bone mass acquisition in adolescent Turner syndrome patients. J Bone Miner Res 15:2005-2010
Costa AM, Lemos-Marini SH, Baptista MT, Morcillo AM, Maciel-Guerra AT, Guerre Jr G 2002 Bone mineralization in Turner syndrome: a transverse study of the determinant factors in 58 patients. J Bone Miner Metab 20:294-297
Saenger P, Wikland KA, Conway GS, Davenport M, Gravholt CH, Hintz R, Hovatta O, Hultcrantz M, Landin-Wilhelmsen K, Lin A, Lippe B, Pasquino AM, Ranke MB, Rosenfeld R, Silberbach M 2001 Recommendations for the diagnosis and management of Turner syndrome. J Clin Endocrinol Metab 86:3061-3069
Massa G, Vanderschueren-Lodeweyckx M 1989 Spondyloepiphyseal dysplasia tarda in Turner syndrome. Acta Paediatr Scand 78:971-974
Lagrou K, Xhrouet-Heinrichs D, Heinrichs C, Craen M, Chanoine JP, Malvaux P, Bourguignon JP 1998 Age-related perception of stature, acceptance of therapy, and psychosocial functioning in human growth hormone-treated girls with Turner's syndrome. J Clin Endocrinol Metab 83:1494-1501
Tanner JM 1962 Growth at adolescence. Oxford, UK: Blackwell Scientific Publications
Tanner JM, Whitehouse RH, Takaishi M 1966 Standards from birth to maturity for height, weight, height velocity and weight velocity: British children 1965. Arch Dis Child 41:454-471, 613-635
Lyon AL, Preece MA, Grant DB 1985 Growth curve for girls with Turner syndrome. Arch Dis Child 60:932-935
Niklasson A, Ericson A, Fryer JG, Karlberg J, Lawrence C, Karlberg P 1991 An update of the Swedish reference standards for weight, length and head circumference at birth for given gestational age (1977-1981). Acta Paediatr Scand 80:756-762
Tanner JM 1970 Standards for children's height at ages 2-9 years allowing for height of parents. Arch Dis Child 45:755-762
Mul D, Fredriks AM, van Buuren S, Oostdijk W, Verloove-Vanhorick SP, Wit JM 2001 Pubertal development in the Netherlands 1965-1997. Pediatr Res 50:479-486
Lippe B, Frane J, and the Genentech National Cooperative Study Group 1991 Growth in Turner syndrome: the United States experience. In: Ranke MB, Rosenfeld RG, eds. Turner syndrome: growth promoting therapies. Amsterdam: Excerpta Medica; 59-65
Rao E, Weiss B, Fukami M, Rump A, Niesler B, Mertz A, Muroya K, Binder G, Kirsch S, Winkelmann M, Nordsiek G, Heinrich U, Breuning MH, Ranke MB, Rosenthal A, Ogata T, Rappold GA 1997 Pseudoautosomal deletions encompassing a novel homeobox gene cause growth failure in idiopathic short stature and Turner syndrome. Nat Genet 16:54-63
de Zegher F, Albertsson-Wikland K, Wollmann HA, Chatelain P, Chaussain JL, Lofstrom A, Jonsson B, Rosenfeld RG 2000 Growth hormone treatment of short children born small for gestational age: responses with continuous and discontinuous regimens over 6 years. J Clin Endocrinol Metab 85:2816-2821
Tauber M 2000 Optimizing growth in Turner syndrome: rationale to use dose escalation studies in GH treatment. In: Saenger P, Pasquino AM, eds. Optimizing health care for Turner patients in the 21st century. Amsterdam: Elsevier Science BV; 177-184
Tanaka T, Satoh M, Tanae A, Hibi I 1995 Bone age maturation during growth promoting and GnRHa treatment in Turner syndrome In: Albertsson-Wikland K, Ranke M, eds. Turner syndrome in a life-span perspective. Amsterdam: Elsevier Science BV; 191-200
Massa G, Maes M, Heinrichs C, Vandeweghe M, Craen M, Vanderschueren-Lodeweyckx M 1993 Influence of spontaneous or induced puberty on the growth promoting effect of treatment with growth hormone in girls with Turner's syndrome. Clin Endocrinol (Oxf) 38:253-260
Bourguignon JP 1988 Linear growth as a function of age at onset of puberty and sex steroid dosage: therapeutic implications. Endocr Rev 9:467-488
Similar publications
Sorry the service is unavailable at the moment. Please try again later.
This website uses cookies to improve user experience. Read more
Save & Close
Accept all
Decline all
Show detailsHide details
Cookie declaration
About cookies
Strictly necessary
Performance
Strictly necessary cookies allow core website functionality such as user login and account management. The website cannot be used properly without strictly necessary cookies.
This cookie is used by Cookie-Script.com service to remember visitor cookie consent preferences. It is necessary for Cookie-Script.com cookie banner to work properly.
Performance cookies are used to see how visitors use the website, eg. analytics cookies. Those cookies cannot be used to directly identify a certain visitor.
Used to store the attribution information, the referrer initially used to visit the website
Cookies are small text files that are placed on your computer by websites that you visit. Websites use cookies to help users navigate efficiently and perform certain functions. Cookies that are required for the website to operate properly are allowed to be set without your permission. All other cookies need to be approved before they can be set in the browser.
You can change your consent to cookie usage at any time on our Privacy Policy page.
