ORBi: Detailled Reference

Article (Scientific journals)

Sugar alcohols and organic acids synthesis in yarrowia lipolytica: Where are we?

Fickers, Patrick; Cheng, H.; Lin, C. S. K.

2020 • In Microorganisms, 8 (4)

Peer Reviewed verified by ORBi

Permalink
https://hdl.handle.net/2268/257017

DOI
10.3390/microorganisms8040574

Files (1)Send to Details Statistics Bibliography Similar publications

Files

Full Text

Microorganisms_2020a.pdf

Publisher postprint (1.4 MB)

All documents in ORBi are protected by a user license.

Send to

RIS BibTex APA Chicago Permalink X Linkedin

Details

Keywords :

Organic acids; Polyols; Sugar alcohols; Yarrowia lipolytica

Abstract :

[en] Sugar alcohols and organic acids that derive from the metabolism of certain microorganisms have a panoply of applications in agro-food, chemical and pharmaceutical industries. The main challenge in their production is to reach a productivity threshold that allow the process to be profitable. This relies on the construction of efficient cell factories by metabolic engineering and on the development of low-cost production processes by using industrial wastes or cheap and widely available raw materials as feedstock. The non-conventional yeast Yarrowia lipolytica has emerged recently as a potential producer of such metabolites owing its low nutritive requirements, its ability to grow at high cell densities in a bioreactor and ease of genome edition. This review will focus on current knowledge on the synthesis of the most important sugar alcohols and organic acids in Y. lipolytica. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.

Disciplines :

Biotechnology

Author, co-author :

Fickers, Patrick ; Université de Liège - ULiège > Département GxABT > Microbial, food and biobased technologies

Cheng, H.; State key laboratory of Microbial Metabolism, School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, China

Lin, C. S. K.; Department of Energy and Environment, School of Energy and Environment, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong

Language :

English

Title :

Sugar alcohols and organic acids synthesis in yarrowia lipolytica: Where are we?

Publication date :

2020

Journal title :

Microorganisms

eISSN :

2076-2607

Publisher :

MDPI AG

Volume :

8

Issue :

4

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 18 February 2021

Statistics

Number of views

40 (5 by ULiège)

Number of downloads

5 (5 by ULiège)

More statistics

Scopus citations^®

64

Scopus citations^®
without self-citations

58

OpenCitations

32

OpenAlex citations

65

Bibliography

Nicaud, J.-M. Yarrowia lipolytica. Yeast 2012, 29, 409–418.
Groenewald, M.; Boekhout, T.; Neuvéglise, C.; Gaillardin, C.; van Dijck, P.W.M.; Wyss, M. Yarrowia lipolytica: Safety assessment of an oleaginous yeast with a great industrial potential. Crit. Rev. Microbiol. 2014, 40, 187–206.
Fickers, P.; Benetti, P.-H.; Waché, Y.; Marty, A.; Mauersberger, S.; Smit, M.S.; Nicaud, J.-M. Hydrophobic substrate utilisation by the yeast Yarrowia lipolytica, and its potential applications. FEMS Yeast Res. 2005, 5, 527–543.
Fickers, P.; Marty, A.; Nicaud, J.M. The lipases from Yarrowia lipolytica: Genetics, production, regulation, biochemical characterization and biotechnological applications. Biotechnol. Adv. 2011, 29, 632–644.
Dujon, B.; Sherman, D.; Fischer, G.; Durrens, P.; Casaregola, S.; Lafontaine, I.; De Montigny, J.; Marck, C.; Neuvéglise, C.; Talla, E. et al. Genome evolution in yeasts. Nature 2004, 430, 35–44.
Ganesan, V.; Spagnuolo, M.; Agrawal, A.; Smith, S.; Gao, D.; Blenner, M. Advances and opportunities in gene editing and gene regulation technology for Yarrowia lipolytica. Microb. Cell Fact. 2019, 18, 208.
Miller, K.K.; Alper, H.S. Yarrowia lipolytica: More than an oleaginous workhorse. Appl. Microbiol. Biotechnol. 2019, 103, 9251–9262.
Do, D.T.H.; Theron, C.W.; Fickers, P. Organic wastes as feedstocks for non-conventional yeast-based bioprocesses. Microorganisms 2019, 7, 229.
Amato, A.; Becci, A.; Beolchini, F. Citric acid bioproduction: The technological innovation change. Crit. Rev. Biotechnol. 2020, 40, 199–212.
Carsanba, E.; Papanikolaou, S.; Fickers, P.; Erten, H. Screening various Yarrowia lipolytica strains for citric acid production. Yeast 2019, 36, 319–327.
Cavallo, E.; Charreau, H.; Cerrutti, P.; Foresti, M.L. Yarrowia lipolytica: A model yeast for citric acid production. FEMS Yeast Res. 2017, 17, doi:10.1093/femsyr/fox084.
Morgunov, I.G.; Kamzolova, S.V.; Lunina, J.N. The citric acid production from raw glycerol by Yarrowia lipolytica yeast and its regulation. Appl. Microbiol. Biotechnol. 2013, 97, 7387–7397.
Beopoulos, A.; Cescut, J.; Haddouche, R.; Uribelarrea, J.-L.; Molina-Jouve, C.; Nicaud, J.-M. Yarrowia lipolytica as a model for bio-oil production. Prog. Lipid Res. 2009, 48, 375–387.
Beopoulos, A.; Chardot, T.; Nicaud, J.-M. Yarrowia lipolytica: A model and a tool to understand the mechanisms implicated in lipid accumulation. Biochimie 2009, 91, 692–696.
Yuzbasheva, E.Y.; Agrimi, G.; Yuzbashev, T.V.; Scarcia, P.; Vinogradova, E.B.; Palmieri, L.; Shutov, A.V.; Kosikhina, I.M.; Palmieri, F.; Sineoky, S.P. The mitochondrial citrate carrier in Yarrowia lipolytica: Its identification, characterization and functional significance for the production of citric acid. Metab. Eng. 2019, 54, 264–274.
Levinson, W.E.; Kurtzman, C.P.; Kuo, T.M. Characterization of Yarrowia lipolytica and related species for citric acid production from glycerol. Enzym. Microb. Technol. 2007, 41, 292–295.
Ochoa-Estopier, A.; Guillouet, S.E. D-stat culture for studying the metabolic shifts from oxidative metabolism to lipid accumulation and citric acid production in Yarrowia lipolytica. J. Biotechnol. 2014, 170, 35–41.
Papanikolaou, S.; Muniglia, L.; Chevalot, I.; Aggelis, G.; Marc, I. Yarrowia lipolytica as a potential producer of citric acid from raw glycerol. J. Appl. Microbiol. 2002, 92, 737–744.
Kamzolova, S.V.; Shamin, R.V.; Stepanova, N.N.; Morgunov, G.I.; Lunina, J.N.; Allayarov, R.K.; Samoilenko, V.A.; Morgunov, I.G. Fermentation conditions and media optimization for isocitric acid production from ethanol by Yarrowia lipolytica. Biomed Res Int. 2018, 2018, doi:10.1155/2018/2543210.
Egermeier, M.; Russmayer, H.; Sauer, M.; Marx, H. Metabolic flexibility of Yarrowia lipolytica growing on glycerol. Front. Microbiol. 2017, 8, 49.
Zhang, S.; Jagtap, S.S.; Deewan, A.; Rao, C.V. pH selectively regulates citric acid and lipid production in Yarrowia lipolytica W29 during nitrogen-limited growth on glucose. J. Biotechnol. 2019, 290, 10–15.
Ferreira, P.; Lopes, M.; Mota, M.; Belo, I. Oxygen mass transfer impact on citric acid production by Yarrowia lipolytica from crude glycerol. Biochem. Eng. J. 2016, 110, 35–42.
Rywińska, A.; Musiał, I.; Rymowicz, W.; Zarowska, B.; Boruczkowski, T. Effect of agitation and aeration on the citric acid production by Yarrowia lipolytica grown on glycerol. Prep. Biochem. Biotechnol. 2012, 42, 279–291.
Sabra, W.; Bommareddy, R.R.; Maheshwari, G.; Papanikolaou, S.; Zeng, A.-P. Substrates and oxygen dependent citric acid production by Yarrowia lipolytica: Insights through transcriptome and fluxome analyses. Microb. Cell. Fact. 2017, 16, 78.
Rywińska, A.; Juszczyk, P.; Wojtatowicz, M.; Rymowicz, W. Chemostat study of citric acid production from glycerol by Yarrowia lipolytica. J. Biotechnol. 2011, 152, 54–57.
Wojtatowicz, M.; Rymowicz, W.; Kautola, H. Comparison of different strains of the yeast Yarrowia lipolytica for citric acid production from glucose hydrol. Appl. Biochem. Biotechnol. 1991, 31, 165–174.
Morgunov, I.G.; Kamzolova, S.V. Physiologo-biochemical characteristics of citrate-producing yeast Yarrowia lipolytica grown on glycerol-containing waste of biodiesel industry. Appl. Microbiol. Biotechnol. 2015, 99, 6443–6450.
Rymowicz, W.; Fatykhova, A.R.; Kamzolova, S.V.; Rywińska, A.; Morgunov, I.G. Citric acid production from glycerol-containing waste of biodiesel industry by Yarrowia lipolytica in batch, repeated batch, and cell recycle regimes. Appl. Microbiol. Biotechnol. 2010, 87, 971–979.
Papanikolaou, S.; Galiotou-Panayotou, M.; Chevalot, I.; Komaitis, M.; Marc, I.; Aggelis, G. Influence of glucose and saturated free-fatty acid mixtures on citric acid and lipid production by Yarrowia lipolytica. Curr. Microbiol. 2006, 52, 134–142.
Imandi, S.B.; Bandaru, V.V.R.; Somalanka, S.R.; Bandaru, S.R.; Garapati, H.R. Application of statistical experimental designs for the optimization of medium constituents for the production of citric acid from pineapple waste. Bioresour. Technol. 2008, 99, 4445–4450.
Papanikolaou, S.; Galiotou-Panayotou, M.; Fakas, S.; Komaitis, M.; Aggelis, G. Citric acid production by Yarrowia lipolytica cultivated on olive-mill wastewater-based media. Bioresour. Technol. 2008, 99, 2419–2428.
Sarris, D.; Sampani, Z.; Rapti, A.; Papanikolaou, S. Valorization of crude glycerol, residue deriving from biodiesel—Production process, with the use of wild-type new isolated Yarrowia lipolytica strains: Production of metabolites with pharmaceutical and biotechnological interest. Curr. Pharm. Biotechnol. 2019, 20, 881–894.
Tzirita, M.; Kremmyda, M.; Sarris, D.; Koutinas, A.A.; Papanikolaou, S. Effect of salt addition upon the production of metabolic compounds by Yarrowia lipolytica cultivated on biodiesel-derived glycerol diluted with olive-mill Wastewaters. Energies 2019, 12, 3649.
Çelik, G.; Bahriye Uçar, F.; Akpınar, O.; Çorbacı, C. Production of citric and isocitric acid by Yarrowia lipolytica strains grown on different carbon sources. Turk. J. Biochem. 2014, 39, 285–290.
Liu, X.-Y.; Chi, Z.; Liu, G.-L.; Wang, F.; Madzak, C.; Chi, Z.-M. Inulin hydrolysis and citric acid production from inulin using the surface-engineered Yarrowia lipolytica displaying inulinase. Metab. Eng. 2010, 12, 469– 476.
Wang, L.-F.; Wang, Z.-P.; Liu, X.-Y.; Chi, Z.-M. Citric acid production from extract of Jerusalem artichoke tubers by the genetically engineered yeast Yarrowia lipolytica strain 30 and purification of citric acid. Bioprocess Biosyst. Eng. 2013, 36, 1759–1766.
Rakicka, M.; Wolniak, J.; Lazar, Z.; Rymowicz, W. Production of high titer of citric acid from inulin. BMC Biotechnol. 2019, 19, 11.
Lazar, Z.; Walczak, E.; Robak, M. Simultaneous production of citric acid and invertase by Yarrowia lipolytica SUC+ transformants. Bioresour. Technol. 2011, 102, 6982–6989.
Ledesma-Amaro, R.; Lazar, Z.; Rakicka, M.; Guo, Z.; Fouchard, F.; Coq, A.-M.C.-L.; Nicaud, J.-M. Metabolic engineering of Yarrowia lipolytica to produce chemicals and fuels from xylose. Metab. Eng. 2016, 38, 115–124.
Workman, M.; Holt, P.; Thykaer, J. Comparing cellular performance of Yarrowia lipolytica during growth on glucose and glycerol in submerged cultivations. AMB Express 2013, 3, 58.
Mirończuk, A.M.; Rzechonek, D.A.; Biegalska, A.; Rakicka, M.; Dobrowolski, A. A novel strain of Yarrowia lipolytica as a platform for value-added product synthesis from glycerol. Biotechnol. Biofuels 2016, 9, 180.
Rzechonek, D.A.; Dobrowolski, A.; Rymowicz, W.; Mirończuk, A.M. Aseptic production of citric and isocitric acid from crude glycerol by genetically modified Yarrowia lipolytica. Bioresour. Technol. 2019, 271, 340–344.
Förster, A.; Jacobs, K.; Juretzek, T.; Mauersberger, S.; Barth, G. Overexpression of the ICL1 gene changes the product ratio of citric acid production by Yarrowia lipolytica. Appl. Microbiol. Biotechnol. 2007, 77, 861– 869.
Liu, X.-Y.; Chi, Z.; Liu, G.-L.; Madzak, C.; Chi, Z.-M. Both decrease in ACL1 gene expression and increase in ICL1 gene expression in marine-derived yeast Yarrowia lipolytica expressing INU1 gene enhance citric acid production from inulin. Mar. Biotechnol. 2013, 15, 26–36.
Tan, M.-J.; Chen, X.; Wang, Y.-K.; Liu, G.-L.; Chi, Z.-M. Enhanced citric acid production by a yeast Yarrowia lipolytica over-expressing a pyruvate carboxylase gene. Bioprocess Biosyst. Eng. 2016, 39, 1289–1296.
Papanikolaou, S.; Beopoulos, A.; Koletti, A.; Thevenieau, F.; Koutinas, A.A.; Nicaud, J.-M.; Aggelis, G. Importance of the methyl-citrate cycle on glycerol metabolism in the yeast Yarrowia lipolytica. J. Biotechnol. 2013, 168, 303–314.
Arslan, N.P.; Aydogan, M.N.; Taskin, M. Citric acid production from partly deproteinized whey under non-sterile culture conditions using immobilized cells of lactose—Positive and cold-adapted Yarrowia lipolytica B9. J. Biotechnol. 2016, 231, 32–39.
Dourou, M.; Kancelista, A.; Juszczyk, P.; Sarris, D.; Bellou, S.; Triantaphyllidou, I.-E.; Rywinska, A.; Papanikolaou, S.; Aggelis, G. Bioconversion of olive mill wastewater into high-added value products. J. Clean. Prod. 2016, 139, 957–969.
Sarris, D.; Stoforos, N.G.; Mallouchos, A.; Kookos, I.K.; Koutinas, A.A.; Aggelis, G.; Papanikolaou, S. Production of added-value metabolites by Yarrowia lipolytica growing in olive mill wastewater-based media under aseptic and non-aseptic conditions. Eng. Life Sci. 2017, 17, 695–709.
Morgunov, I.G.; Kamzolova, S.V.; Karpukhina, O.V.; Bokieva, S.B.; Inozemtsev, A.N. Biosynthesis of isocitric acid in repeated-batch culture and testing of its stress-protective activity. Appl. Microbiol. Biotechnol. 2019, 103, 3549–3558.
Finogenova, T.V.; Morgunov, I.G.; Kamzolova, S.V.; Chernyavskaya, O.G. Organic acid production by the yeast Yarrowia lipolytica: A review of prospects. Appl. Biochem. Microbiol. 2005, 41, 418–425.
Yang, J.; Kim, M.J.; Yoon, W.; Kim, E.Y.; Kim, H.; Lee, Y.; Min, B.; Kang, K.S.; Son, J.H.; Park, H.T.; et al. Isocitrate protects DJ-1 null dopaminergic cells from oxidative stress through NADP+-dependent isocitrate dehydrogenase (IDH). PLoS Genet. 2017, 13, e1006975.
Bullin, K.; Hennig, L.; Herold, R.; Krautscheid, H.; Richter, K.; Sicker, D. An optimized method for an (2R,3S)-isocitric acid building block. Mon. Chem. 2019, 150, 247–253.
Moore, G.L.; Stringham, R.W.; Teager, D.S.; Yue, T.-Y. Practical synthesis of the bicyclic darunavir side chain: (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol from monopotassium isocitrate. Org. Process Res. Dev. 2017, 21, 98–106.
Holz, M.; Förster, A.; Mauersberger, S.; Barth, G. Aconitase overexpression changes the product ratio of citric acid production by Yarrowia lipolytica. Appl. Microbiol. Biotechnol. 2009, 81, 1087–1096.
Finogenova, T.V.; Shishkanova, N.V.; Fausek, E.A.; Eremina, S.S. Biosynthesis of isocitric acid from ethanol by yeasts. Appl. Microbiol. Biotechnol. 1991, 36, 231–235.
Kamzolova, S.V.; Dedyukhina, E.G.; Samoilenko, V.A.; Lunina, J.N.; Puntus, I.F.; Allayarov, R.L.; Chiglintseva, M.N.; Mironov, A.A.; Morgunov, I.G. Isocitric acid production from rapeseed oil by Yarrowia lipolytica yeast. Appl. Microbiol. Biotechnol. 2013, 97, 9133–9144.
Kamzolova, S.V.; Morgunov, I.G. Microbial production of (2R,3S)-isocitric acid: State of the arts and prospects. Appl. Microbiol. Biotechnol. 2019, 103, 9321–9333.
Kamzolova, S.V.; Vinokurova, N.G.; Lunina, J.N.; Zelenkova, N.F.; Morgunov, I.G. Production of technical-grade sodium citrate from glycerol-containing biodiesel waste by Yarrowia lipolytica. Bioresour. Technol. 2015, 193, 250–255.
Aurich, A.; Hofmann, J.; Oltrogge, R.; Wecks, M.; Gläser, R.; Blömer, L.; Mauersberger, S.; Müller, R.A.; Sicker, D.; Giannis, A. Improved isolation of microbiologically produced (2R,3S)-Isocitric acid by adsorption on activated carbon and recovery with methanol. Org. Process Res. Dev. 2017, 21, 866–870.
Liu, X.; Lv, J.; Zhang, T.; Deng, Y. Citric acid production from hydrolysate of pretreated straw cellulose by Yarrowia lipolytica SWJ-1b using batch and fed-batch cultivation. Prep. Biochem. Biotechnol. 2015, 45, 825–835.
Kamzolova, S.V.; Allayarov, R.K.; Lunina, J.N.; Morgunov, I.G. The effect of oxalic and itaconic acids on threo-Ds-isocitric acid production from rapeseed oil by Yarrowia lipolytica. Bioresour. Technol. 2016, 206, 128– 133.
Laptev, I.A.; Filimonova, N.A.; Allayarov, R.K.; Kamzolova, S.V.; Samoilenko, V.A.; Sineoky, S.P.; Morgunov, I.G. New recombinant strains of the yeast Yarrowia lipolytica with overexpression of the aconitate hydratase gene for the obtainment of isocitric acid from rapeseed oil. Appl. Biochem. Microbiol. 2016, 52, 699–704.
Oyedotun, K.S.; Lemire, B.D. The quaternary structure of the Saccharomyces cerevisiae succinate dehydrogenase. Homology modeling, cofactor docking, and molecular dynamics simulation studies. J. Biol. Chem. 2004, 279, 9424–9431.
Yuzbashev, T.V.; Yuzbasheva, E.Y.; Sobolevskaya, T.I.; Laptev, I.A.; Vybornaya, T.V.; Larina, A.S.; Matsui, K.; Fukui, K.; Sineoky, S.P. Production of succinic acid at low pH by a recombinant strain of the aerobic yeast Yarrowia lipolytica. Biotechnol. Bioeng. 2010, 107, 673–682.
Ahn, J.H.; Jang, Y.-S.; Lee, S.Y. Production of succinic acid by metabolically engineered microorganisms. Curr. Opin. Biotechnol. 2016, 42, 54–66.
Choi, S.; Song, C.W.; Shin, J.H.; Lee, S.Y. Biorefineries for the production of top building block chemicals and their derivatives. Metab. Eng. 2015, 28, 223–239.
Yuzbashev, T.V.; Yuzbasheva, E.Y.; Laptev, I.A.; Sobolevskaya, T.I.; Vybornaya, T.V.; Larina, A.S.; Gvilava, I.T.; Antonova, S.V.; Sineoky, S.P. Is it possible to produce succinic acid at a low pH? Bioeng. Bugs 2011, 2, 115–119.
Yuzbashev, T.V.; Bondarenko, P.Y.; Sobolevskaya, T.I.; Yuzbasheva, E.Y.; Laptev, I.A.; Kachala, V.V.; Fedorov, A.S.; Vybornaya, T.V.; Larina, A.S.; Sineoky, S.P. Metabolic evolution and 13C flux analysis of a succinate dehydrogenase deficient strain of Yarrowia lipolytica. Biotechnol. Bioeng. 2016, 113, 2425–2432.
Bondarenko, P.Yu.; Fedorov, A.S.; Sineoky, S.P. Optimization of repeated-batch fermentation of a recombinant strain of the yeast Yarrowia lipolytica for succinic acid production at Low pH. Appl. Biochem. Microbiol. 2017, 53, 882–887.
Jost, B.; Holz, M.; Aurich, A.; Barth, G.; Bley, T.; Müller, R.A. The influence of oxygen limitation for the production of succinic acid with recombinant strains of Yarrowia lipolytica. Appl. Microbiol. Biotechnol. 2015, 99, 1675–1686.
Gao, C.; Yang, X.; Wang, H.; Rivero, C.P.; Li, C.; Cui, Z.; Qi, Q.; Lin, C.S.K. Robust succinic acid production from crude glycerol using engineered Yarrowia lipolytica. Biotechnol. Biofuels 2016, 9, 179.
Li, C.; Yang, X.; Gao, S.; Wang, H.; Lin, C.S.K. High efficiency succinic acid production from glycerol via in situ fibrous bed bioreactor with an engineered Yarrowia lipolytica. Bioresour. Technol. 2017, 225, 9–16.
Yang, X.; Wang, H.; Li, C.; Lin, C.S.K. Restoring of glucose metabolism of engineered Yarrowia lipolytica for succinic acid production via a simple and efficient adaptive evolution Strategy. J. Agric. Food Chem. 2017, 65, 4133–4139.
Sauer, M.; Porro, D.; Mattanovich, D.; Branduardi, P. Microbial production of organic acids: Expanding the markets. Trends Biotechnol. 2008, 26, 100–108.
Li, C.; Gao, S.; Li, X.; Yang, X.; Lin, C.S.K. Efficient metabolic evolution of engineered Yarrowia lipolytica for succinic acid production using a glucose-based medium in an in situ fibrous bioreactor under low-pH condition. Biotechnol Biofuels 2018, 11, 236.
Cui, Z.; Gao, C.; Li, J.; Hou, J.; Lin, C.S.K.; Qi, Q. Engineering of unconventional yeast Yarrowia lipolytica for efficient succinic acid production from glycerol at low pH. Metab. Eng. 2017, 42, 126–133.
Kamzolova, S.V.; Yusupova, A.I.; Vinokurova, N.G.; Fedotcheva, N.I.; Kondrashova, M.N.; Finogenova, T.V.; Morgunov, I.G. Chemically assisted microbial production of succinic acid by the yeast Yarrowia lipolytica grown on ethanol. Appl. Microbiol. Biotechnol. 2009, 83, 1027–1034.
Kamzolova, S.V.; Vinokurova, N.G.; Dedyukhina, E.G.; Samoilenko, V.A.; Lunina, J.N.; Mironov, A.A.; Allayarov, R.K.; Morgunov, I.G. The peculiarities of succinic acid production from rapeseed oil by Yarrowia lipolytica yeast. Appl. Microbiol. Biotechnol. 2014, 98, 4149–4157.
Vong, W.C.; Au yang, K.L.C.; Liu, S.-Q. Okara (Soybean residue) biotransformation by yeast Yarrowia lipolytica. Int. J. Food Microbiol. 2016, 235, 1–9.
Li, C.; Gao, S.; Yang, X.; Lin, C.S.K. Green and sustainable succinic acid production from crude glycerol by engineered Yarrowia lipolytica via agricultural residue based in situ fibrous bed bioreactor. Bioresour. Technol. 2018, 249, 612–619.
Song, Y.; Li, J.; Shin, H.; Liu, L.; Du, G.; Chen, J. Biotechnological production of alpha-keto acids: Current status and perspectives. Bioresour. Technol. 2016, 219, 716–724.
Tsugawa, R.; Nakase, T.; Kobayashi, T.; Yamashita, K.; Okumura, S. Fermentation of n-Paraffins by Yeast. Agric. Biol. Chem. 1969, 33, 158–167.
Kamzolova, S.V.; Morgunov, I.G. α-Ketoglutaric acid production from rapeseed oil by Yarrowia lipolytica yeast. Appl. Microbiol. Biotechnol. 2013, 97, 5517–5525.
Ryu, S.; Labbé, N.; Trinh, C.T. Simultaneous saccharification and fermentation of cellulose in ionic liquid for efficient production of α-ketoglutaric acid by Yarrowia lipolytica. Appl. Microbiol. Biotechnol. 2015, 99, 4237–4244.
Kamzolova, S.V.; Chiglintseva, M.N.; Lunina, J.N.; Morgunov, I.G. α-Ketoglutaric acid production by Yarrowia lipolytica and its regulation. Appl. Microbiol. Biotechnol. 2012, 96, 783–791.
Zhou, J.; Yin, X.; Madzak, C.; Du, G.; Chen, J. Enhanced α-ketoglutarate production in Yarrowia lipolytica WSH-Z06 by alteration of the acetyl-CoA metabolism. J. Biotechnol. 2012, 161, 257–264.
Yin, X.; Madzak, C.; Du, G.; Zhou, J.; Chen, J. Enhanced alpha-ketoglutaric acid production in Yarrowia lipolytica WSH-Z06 by regulation of the pyruvate carboxylation pathway. Appl. Microbiol. Biotechnol. 2012, 96, 1527–1537.
Yovkova, V.; Otto, C.; Aurich, A.; Mauersberger, S.; Barth, G. Engineering the α-ketoglutarate overproduction from raw glycerol by overexpression of the genes encoding NADP+-dependent isocitrate dehydrogenase and pyruvate carboxylase in Yarrowia lipolytica. Appl. Microbiol. Biotechnol. 2014, 98, 2003– 2013.
Guo, H.; Liu, P.; Madzak, C.; Du, G.; Zhou, J.; Chen, J. Identification and application of keto acids transporters in Yarrowia lipolytica. Sci. Rep. 2015, 5, 8138.
Kamzolova, S.V.; Vinokurova, N.G.; Shemshura, O.N.; Bekmakhanova, N.E.; Lunina, J.N.; Samoilenko, V.A.; Morgunov, I.G. The production of succinic acid by yeast Yarrowia lipolytica through a two-step process. Appl. Microbiol. Biotechnol. 2014, 98, 7959–7969.
Blazeck, J.; Hill, A.; Jamoussi, M.; Pan, A.; Miller, J.; Alper, H.S. Metabolic engineering of Yarrowia lipolytica for itaconic acid production. Metab. Eng. 2015, 32, 66–73.
Zhao, C.; Cui, Z.; Zhao, X.; Zhang, J.; Zhang, L.; Tian, Y.; Qi, Q.; Liu, J. Enhanced itaconic acid production in Yarrowia lipolytica via heterologous expression of a mitochondrial transporter MTT. Appl. Microbiol. Biotechnol. 2019, 103, 2181–2192.
Vidra, A.; Németh, Á. Bio-produced Acetic Acid: A Review. Period. Polytech. Chem. Eng. 2018, 62, 245–256.
Papanikolaou, S.; Chatzifragkou, A.; Fakas, S.; Galiotou-Panayotou, M.; Komaitis, M.; Nicaud, J.-M.; Aggelis, G. Biosynthesis of lipids and organic acids by Yarrowia lipolytica strains cultivated on glucose. Eur. J. Lipid Sci. Technol. 2009, 111, 1221–1232.
Rice, T.; Zannini, E.; Arendt, E.K.; Coffey, A. A review of polyols—Biotechnological production, food applications, regulation, labeling and health effects. Crit. Rev. Food Sci. Nutr. 2019, doi:10.1080/10408398.2019.1625859.
Carly, F.; Fickers, P. Erythritol production by yeasts: A snapshot of current knowledge. Yeast 2018, 35, 455– 463.
Dulermo, T.; Lazar, Z.; Dulermo, R.; Rakicka, M.; Haddouche, R.; Nicaud, J.-M. Analysis of ATP-citrate lyase and malic enzyme mutants of Yarrowia lipolytica points out the importance of mannitol metabolism in fatty acid synthesis. Biochim. Biophys. Acta 2015, 1851, 1107–1117.
Janek, T.; Dobrowolski, A.; Biegalska, A.; Mirończuk, A.M. Characterization of erythrose reductase from Yarrowia lipolytica and its influence on erythritol synthesis. Microb. Cell Fact. 2017, 16, 118.
Cheng, H.; Wang, S.; Bilal, M.; Ge, X.; Zhang, C.; Fickers, P.; Cheng, H. Identification, characterization of two NADPH-dependent erythrose reductases in the yeast Yarrowia lipolytica and improvement of erythritol productivity using metabolic engineering. Microb. Cell Fact. 2018, 17, 133.
Niang, P.M.; Arguelles-Arias, A.; Steels, S.; Denies, O.; Nicaud, J.-M.; Fickers, P. In Yarrowia lipolytica erythritol catabolism ends with erythrose phosphate. Cell Biol. Int. 2020, 44, 651–660.
Rzechonek, D.A.; Neuvéglise, C.; Devillers, H.; Rymowicz, W.; Mirończuk, A.M. EUF1—A newly identified gene involved in erythritol utilization in Yarrowia lipolytica. Sci. Rep. 2017, 7, 1–8.
Mirończuk, A.M.; Biegalska, A.; Zugaj, K.; Rzechonek, D.A.; Dobrowolski, A. A role of a newly identified isomerase from Yarrowia lipolytica in erythritol catabolism. Front. Microbiol. 2018, 9, 1122.
Regnat, K.; Mach, R.L.; Mach-Aigner, A.R. Erythritol as sweetener—Wherefrom and whereto? Appl. Microbiol. Biotechnol. 2018, 102, 587–595.
Rzechonek, D.A.; Dobrowolski, A.; Rymowicz, W.; Mirończuk, A.M. Recent advances in biological production of erythritol. Crit. Rev. Biotechnol. 2018, 38, 620–633.
Carly, F.; Vandermies, M.; Telek, S.; Steels, S.; Thomas, S.; Nicaud, J.-M.; Fickers, P. Enhancing erythritol productivity in Yarrowia lipolytica using metabolic engineering. Metab. Eng. 2017, 42, 19–24.
Mirończuk, A.M.; Biegalska, A.; Dobrowolski, A. Functional overexpression of genes involved in erythritol synthesis in the yeast Yarrowia lipolytica. Biotechnol Biofuels 2017, 10, 77.
Liu, X.; Lv, J.; Xu, J.; Xia, J.; Dai, B.; Xu, X.; Xu, J. Erythritol production by Yarrowia lipolytica mutant strain M53 generated through atmospheric and room temperature plasma mutagenesis. Food Sci. Biotechnol. 2017, 26, 979–986.
Rakicka, M.; Biegalska, A.; Rymowicz, W.; Dobrowolski, A.; Mirończuk, A.M. Polyol production from waste materials by genetically modified Yarrowia lipolytica. Bioresour. Technol. 2017, 243, 393–399.
Da Silva, L.V.; Coelho, M.A.Z.; Amaral, P.F.F.; Fickers, P. A novel osmotic pressure strategy to improve erythritol production by Yarrowia lipolytica from glycerol. Bioprocess Biosyst. Eng. 2018, 41, 1883–1886.
Liu, X.; Yan, Y.; Zhao, P.; Song, J.; Yu, X.; Wang, Z.; Xia, J.; Wang, X. Oil crop wastes as substrate candidates for enhancing erythritol production by modified Yarrowia lipolytica via one-step solid state fermentation. Bioresour. Technol. 2019, 294, 122194.
Rakicka-Pustułka, M.; Mirończuk, A.M.; Celińska, E.; Białas, W.; Rymowicz, W. Scale-up of the erythritol production technology—Process simulation and techno-economic analysis. J. Clean. Prod. 2020, 257, 120533.
Carly, F.; Steels, S.; Telek, S.; Vandermies, M.; Nicaud, J.-M.; Fickers, P. Identification and characterization of EYD1, encoding an erythritol dehydrogenase in Yarrowia lipolytica and its application to bioconvert erythritol into erythrulose. Bioresour. Technol. 2018, 247, 963–969.
Chi, P.; Wang, S.; Ge, X.; Bilal, M.; Fickers, P.; Cheng, H. Efficient D-threitol production by an engineered strain of Yarrowia lipolytica overexpressing xylitol dehydrogenase gene from Scheffersomyces stipitis. Biochem. Eng. J. 2019, 149, 107259.
Zhang, M.; Gu, L.; Cheng, C.; Ma, J.; Xin, F.; Liu, J.; Wu, H.; Jiang, M. Recent advances in microbial production of mannitol: Utilization of low-cost substrates, strain development and regulation strategies. World J Microbiol. Biotechnol. 2018, 34, 41.
Sekova, V.Y.; Dergacheva, D.I.; Isakova, E.P.; Gessler, N.N.; Tereshina, V.M.; Deryabina, Y.I. Soluble sugar and lipid readjustments in the Yarrowia lipolytica yeast at various temperatures and pH. Metabolites 2019, 9, 307.
Tomaszewska, L.; Rywińska, A.; Gładkowski, W. Production of erythritol and mannitol by Yarrowia lipolytica yeast in media containing glycerol. J. Ind. Microbiol. Biotechnol. 2012, 39, 1333–1343.
Sarris, D.; Rapti, A.; Papafotis, N.; Koutinas, A.A.; Papanikolaou, S. Production of added-value chemical compounds through bioconversions of olive-mill wastewaters blended with crude glycerol by a Yarrowia lipolytica strain. Molecules 2019, 24, 222.
Kordowska-Wiater, M. Production of arabitol by yeasts: Current status and future prospects. J. Appl. Microbiol. 2015, 119, 303–314.
Babaei, M.; Rueksomtawin Kildegaard, K.; Niaei, A.; Hosseini, M.; Ebrahimi, S.; Sudarsan, S.; Angelidaki, I.; Borodina, I. Engineering oleaginous yeast as the host for fermentative succinic acid production from glucose. Front. Bioeng. Biotechnol. 2019, 7, 361.

Similar publications