Article (Scientific journals)
Sugar alcohols and organic acids synthesis in yarrowia lipolytica: Where are we?
Fickers, Patrick; Cheng, H.; Lin, C. S. K.
2020In Microorganisms, 8 (4)
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Keywords :
Organic acids; Polyols; Sugar alcohols; Yarrowia lipolytica
Abstract :
[en] Sugar alcohols and organic acids that derive from the metabolism of certain microorganisms have a panoply of applications in agro-food, chemical and pharmaceutical industries. The main challenge in their production is to reach a productivity threshold that allow the process to be profitable. This relies on the construction of efficient cell factories by metabolic engineering and on the development of low-cost production processes by using industrial wastes or cheap and widely available raw materials as feedstock. The non-conventional yeast Yarrowia lipolytica has emerged recently as a potential producer of such metabolites owing its low nutritive requirements, its ability to grow at high cell densities in a bioreactor and ease of genome edition. This review will focus on current knowledge on the synthesis of the most important sugar alcohols and organic acids in Y. lipolytica. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.
Disciplines :
Biotechnology
Author, co-author :
Fickers, Patrick ;  Université de Liège - ULiège > Département GxABT > Microbial, food and biobased technologies
Cheng, H.;  State key laboratory of Microbial Metabolism, School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, China
Lin, C. S. K.;  Department of Energy and Environment, School of Energy and Environment, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong
Language :
English
Title :
Sugar alcohols and organic acids synthesis in yarrowia lipolytica: Where are we?
Publication date :
2020
Journal title :
Microorganisms
eISSN :
2076-2607
Publisher :
MDPI AG
Volume :
8
Issue :
4
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 18 February 2021

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