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Sugar alcohols and organic acids synthesis in yarrowia lipolytica: Where are we?

Fickers, Patrick; Cheng, H.; Lin, C. S. K.

2020 • In Microorganisms, 8 (4)

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https://hdl.handle.net/2268/257017

DOI
10.3390/microorganisms8040574

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Keywords :

Organic acids; Polyols; Sugar alcohols; Yarrowia lipolytica

Abstract :

[en] Sugar alcohols and organic acids that derive from the metabolism of certain microorganisms have a panoply of applications in agro-food, chemical and pharmaceutical industries. The main challenge in their production is to reach a productivity threshold that allow the process to be profitable. This relies on the construction of efficient cell factories by metabolic engineering and on the development of low-cost production processes by using industrial wastes or cheap and widely available raw materials as feedstock. The non-conventional yeast Yarrowia lipolytica has emerged recently as a potential producer of such metabolites owing its low nutritive requirements, its ability to grow at high cell densities in a bioreactor and ease of genome edition. This review will focus on current knowledge on the synthesis of the most important sugar alcohols and organic acids in Y. lipolytica. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.

Disciplines :

Biotechnology

Author, co-author :

Fickers, Patrick ; Université de Liège - ULiège > Département GxABT > Microbial, food and biobased technologies

Cheng, H.; State key laboratory of Microbial Metabolism, School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, China

Lin, C. S. K.; Department of Energy and Environment, School of Energy and Environment, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong

Language :

English

Title :

Sugar alcohols and organic acids synthesis in yarrowia lipolytica: Where are we?

Publication date :

2020

Journal title :

Microorganisms

eISSN :

2076-2607

Publisher :

MDPI AG

Volume :

8

Issue :

4

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 18 February 2021

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50

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32

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