Promising advancement in fermentative succinic acid production by yeast hosts

[en] As a platform chemical with various applications, succinic acid (SA) is currently produced by petrochemical processing from oil-derived substrates such as maleic acid. In order to replace the environmental unsustainable hydrocarbon economy with a renewable environmentally sound carbohydrate economy, bio-based SA production process has been developed during the past two decades. In this review, recent advances in the valorization of solid organic wastes including mixed food waste, agricultural waste and textile waste for efficient, green and sustainable SA production have been reviewed. Firstly, the application, market and key global players of bio-SA are summarized. Then achievements in SA production by several promising yeasts including Saccharomyces cerevisiae and Yarrowia lipolytica are detailed, followed by calculation and comparison of SA production costs between oil-based substrates and raw materials. Lastly, challenges in engineered microorganisms and fermentation processes are presented together with perspectives on the development of robust yeast SA producers via genome-scale metabolic optimization and application of low-cost raw materials as fermentation substrates. This review provides valuable insights for identifying useful directions for future bio-SA production improvement. © 2020 Elsevier B.V.

Disciplines :

Biotechnology

Author, co-author :

Li, C.; Shenzhen Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, China

Ong, K. L.; School of Energy and Environment, City University of Hong Kong, Hong Kong

Cui, Z.; State Key Laboratory of Microbial Technology, Shandong University, Qingdao, 266237, China

Sang, Z.; Shenzhen Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, China, School of Life Sciences, Zhengzhou University, Zhengzhou, China

Li, Xuefang

Patria, R. D.; School of Energy and Environment, City University of Hong Kong, Hong Kong

Qi, Q.; State Key Laboratory of Microbial Technology, Shandong University, Qingdao, 266237, China

Fickers, Patrick ; Université de Liège - ULiège > Département GxABT > Microbial, food and biobased technologies

Yan, J.; Shenzhen Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, China

Lin, C. S. K.; School of Energy and Environment, City University of Hong Kong, Hong Kong

Language :

English

Title :

Promising advancement in fermentative succinic acid production by yeast hosts

Publication date :

2021

Journal title :

Journal of Hazardous Materials

ISSN :

0304-3894

eISSN :

1873-3336

Publisher :

Elsevier B.V.

Volume :

401

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 18 February 2021

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