Article (Scientific journals)
Should a neck dissection be performed on patients with cN0 adenoid cystic carcinoma? A REFCOR propensity score matching study
Atallah, S.; Moya-Plana, A.; Malard, O. et al.
2020In European Journal of Cancer
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Keywords :
Adenoid cystic carcinoma; Neck dissection; REFCOR; Salivary gland cancer; Surgery
Abstract :
[en] Background: Patterns of nodal involvement in adenoid cystic carcinoma (ACC) of the head and neck have not been sufficiently assessed to guide a decision of prophylactic neck dissection (ND). The objective of this study is to analyse the influence of ND on event-free survival (EFS) for patients with cN0 ACC. Patients and methods: A multicentre prospective study was conducted between 2009 and 2018. Patients presenting cN0 non-metastatic ACC on any site, and who received surgery on the tumour, were included. EFS was the main judgement criterion. A comparative survival analysis between the groups that received a ND versus those that did not was performed, using a propensity score. Analyses were carried out using the R software. Results: Between 2009 and 2018, 322 patients with cN0 ACC were included, out of which 58% were female. The average age was 53 years. Tumours were in minor salivary glands in 58% of cases, and 52% had T3/T4 stages. ND was performed on 46% of patients. Out of them, seven had histological lymph node invasion, out of which six had tumour infiltration in the mucosa of oral cavity. After propensity score, the median EFS for N0 patients with ND was 72 months (95% Confidence Interval (CI) [48–81]), compared to 73 months (95% CI [52–85]) for patients without ND (HR = 1.33; 95% CI [0.82–2.16]; p = 0.2). Conclusion: ND of cN0 patients does not provide any benefit on EFS, which suggests that its application on such patients is not necessary. © 2020 Elsevier Ltd
Disciplines :
Otolaryngology
Author, co-author :
Atallah, S.;  Sorbonne University, APHP, Department of ENT-Head and Neck Surgery, Tenon Hospital, 4 rue de la chine, Paris, 75020, France, Doctoral School of Public Health, CESP, University of Paris Sud, 16 Avenue Paul Vaillant Couturier, Villejuif, 94807, France
Moya-Plana, A.;  Department of Head and Neck Oncology, Gustave Roussy Cancer Campus, 114, rue Edouard Vaillant, Villejuif, 94805, France
Malard, O.;  Department of ENT-Head and Neck Surgery, Nantes University Hospital, 1 Place Alexis-Ricordeau, Nantes, 44000, France
Poissonnet, G.;  Department of ENT-Head and Neck Surgery, Centre Antoine-Lacassagne-IUFC, 31 Avenue de Valombrose, Nice, 06189, France
Fakhry, N.;  Department of ENT-Head and Neck Surgery, University Hospital of Marseille, APHM, Marseille, 13915, France
Bettoni, J.;  Department of Maxillofacial Surgery, University Hospital of Amiens-Picardy, Avenue René Laennec, Amiens, 80000, France
Gallet, P.;  Department of ENT-Head and Neck Surgery, Regional University Hospital of Nancy, Hospital of Brabois, Nancy, 54035, France
RANSY, Pierre ;  Centre Hospitalier Universitaire de Liège - CHU > Autres Services Médicaux > Service d'ORL, d'audiophonologie et de chir. cervico-faciale
Vergez, S.;  Department of ENT-Head and Neck Surgery, University Cancer Institute Toulouse, Toulouse University Hospital, 1 avenue Irène Joliot-Curie, Toulouse, 31400, France
De Gabory, L.;  Department of ENT-Head and Neck Surgery, University Hospital of Bordeaux, Hôpital Pellegrin, Centre Michelet, Place Amélie Raba-Léon, Bordeaux, 33076, France
Evrard, D.;  Department of ENT-Head and Neck Surgery, Hospital Bichat, APHP, Paris, 75018, France
Lesnik, M.;  Department of ENT-Head and Neck Surgery, Curie Institute, 26 rue d'Ulm, Paris, 75005, France
Philouze, P.;  Department of ENT-Head and Neck Surgery, Hospices Civils de Lyon, Lyon-Nord University Hospital, 103 Grande Rue de la Croix Rousse, Lyon, 69000, France
Bertolus, C.;  Department of Oral and Maxillofacial Surgery, Sorbonne University, Pitié-Salpétrière Hospital, APHP, Paris, 75013, France
Schultz, P.;  Department of ENT-Head and Neck Surgery, University Hospital of StrasbourgStrasbourg 67000, France
Morinière, S.;  Department of ENT-Head and Neck Surgery, Tours Bretonneau University Hospital, 2 Boulevard Tonnellé, Tours, 37000, France
Bastit, V.;  Department of ENT-Head and Neck Surgery, François Baclesse Centre, 3 rue du Général Harris, Caen, 14000, France
Righini, C. A.;  Department of ENT-Head and Neck Surgery, Grenoble Alpes University Hospital, CS 10217, Grenoble, 38043, France
Mirghani, H.;  Department of ENT-Head and Neck Surgery, Georges Pompidou European Hospital, AP-HP, 20, rue Leblanc, Paris, 75015, France
Jegoux, F.;  Department of ENT-Head and Neck Surgery, Rennes University Hospital, 2 Rue Henri Le Guilloux, Rennes, 35000, France
Mauvais, O.;  Department of ENT-Head and Neck Surgery, University Hospital of Besançon, France, Besançon, 25000, France
Biau, J.;  Department of Radiotherapy, Jean Perrin Centre, University Clermont Auvergne, Clermont-Ferrand, 63100, France
Dufour, X.;  Department of ENT-Head and Neck and Maxillofacial Surgery, University Hospital of Poitiers, 2 Rue de la Milétrie, CS 90577, Poitiers, 86021, France
Bon-Mardion, N.;  Department of ENT-Head and Neck Surgery, Rouen University Hospital, 1 rue de Germont, Rouen, 76031, France
Brenet, E.;  Department of ENT-Head and Neck Surgery, Robert Debré University Hospital, Reims, France
Verillaud, B.;  Department of ENT-Head and Neck Surgery, Lariboisière University Hospital,INSERM U1141, Paris Diderot University, APHP, Paris, 75010, France
Baujat, B.;  Sorbonne University, APHP, Department of ENT-Head and Neck Surgery, Tenon Hospital, 4 rue de la chine, Paris, 75020, France
More authors (17 more) Less
Language :
English
Title :
Should a neck dissection be performed on patients with cN0 adenoid cystic carcinoma? A REFCOR propensity score matching study
Publication date :
2020
Journal title :
European Journal of Cancer
ISSN :
0959-8049
eISSN :
1879-0852
Publisher :
Elsevier Ltd
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
ACCRF - Adenoid Cystic Carcinoma Research Foundation [US-MA] [US-MA]
Available on ORBi :
since 18 February 2021

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