Coordination between Transport and Local Translation in Neurons

[en] The axonal microtubules (MTs) support long-distance transport of cargoes that are dispatched to distinct cellular subcompartments. Among them, mRNAs are directly transported in membraneless ribonucleoprotein (RNP) granules that, together with ribosomes, can also hitchhike on fast-moving membrane-bound organelles for accurate transport along MTs. These organelles serve as platforms for mRNA translation, thus generating axonal foci of newly synthesized proteins. Local translation along axons not only supports MT network integrity but also modulates the processivity and function of molecular motors to allow proper traf- ficking of cargoes along MTs. Thus, identifying the mechanisms that coordinate axonal transport with local protein synthesis will shed new light on the processes underlying axon development and maintenance, whose deregulation often contribute to neurological disorders.

Disciplines :

Biochemistry, biophysics & molecular biology

Author, co-author :

Broix, Loïc ^✱; Université de Liège - ULiège > GIGA Stem Cells - Molecular Regulation of Neurogenesis

Turchetto, Silvia ^✱; Université de Liège - ULiège > GIGA Stem Cells - Molecular Regulation of Neurogenesis

Nguyen, Laurent ; Université de Liège - ULiège > GIGA Stem Cells - Molecular Regulation of Neurogenesis

^✱ These authors have contributed equally to this work.

Language :

English

Title :

Coordination between Transport and Local Translation in Neurons

Publication date :

2021

Journal title :

Trends in Cell Biology

ISSN :

0962-8924

eISSN :

1879-3088

Publisher :

Elsevier, Netherlands

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 16 February 2021

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2 (2 by ULiège)

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