Inhibin: From Concept to Reality

Androgens; Animal; Biological Assay; Cattle; Cells, Cultured; Estrogens; Estrus; Female; Follicle Stimulating Hormone; Human; Hypothalamus; Inhibins; Male; Ovarian Follicle; Pituitary Gland; Pregnancy; Proteins; Radioimmunoassay; Rats; Rete Testis; Semen; Sheep; Spermatogenesis; Testicular Hormones; Testis; Animalia

Abstract :

[en] This chapter describes the concept of the hormone—Inhibin. This hormone is formed in the seminiferous tubules by Sertoli cells in males and by granulosa cells in the follicles of females. Inhibin is peptidic in nature. Its biological action is destroyed by digestion with trypsin or pepsin and by heat. It induces antibodies capable of neutralizing endogenous inhibin in adult male or female animals into which they are injected. Inhibin exerts preferential inhibition on the synthesis and release of follicle-stimulating hormone (FSH) by pituitary gonadotrophs maintained in culture. The dose requires to exert an effect on luteinizing hormone (LH) is much higher. It reduces the amount of endogenous LH-releasing hormone (RH) in the hypothalamus maintained in culture. In the intact animals, the observed effect on gonadotropin levels is the result of the action of inhibin at both sites. Inhibin has no effect on the secretion of thyroid-stimulating hormone (TSH), prolactin, or growth hormone either in vivo or in vitro. It also has an effect on gonadal function in males and females by a reduction of FSH secretion, but a direct action on the gonad also is suspected. © 1979, Academic Press Inc. All rights reserved. © 1979, Academic Press Inc.

Disciplines :

Endocrinology, metabolism & nutrition

Author, co-author :

Franchimont, Paul; Université de Liège - ULiège

Verstraelen-Proyard, J.; Radioimmunoassay Laboratory, Institute of Medicine, University of Liège, Liège, Belgium

Hazee-Hagelstein, M. T.; Radioimmunoassay Laboratory, Institute of Medicine, University of Liège, Liège, Belgium

Renard, C.; Université de Liège - ULiège

Demoulin, André

Bourguignon, Jean-Pierre ; Université de Liège - ULiège > Département des sciences cliniques > Département des sciences cliniques

Hustin, Jean

Language :

English

Title :

Inhibin: From Concept to Reality

Publication date :

1980

Journal title :

Vitamins and Hormones

ISSN :

0083-6729

Publisher :

Elsevier, United States

Volume :

Issue :

Pages :

243-302

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 02 February 2021

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