Article (Scientific journals)
Comparative effects of neonatal and prepubertal castration on craniofacial growth in rats
Verdonck, A.; De Ridder, L.; Verbeke, G. et al.
1998In Archives of Oral Biology, 43 (11), p. 861-871
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Keywords :
Rats; Time Factors; Androgen Antagonists; Animals; Sexual Maturation; Cephalometry; Testosterone; Maxillofacial Development; Orchiectomy
Abstract :
[en] The role of endogenous testosterone in the craniofacial growth of the young male rat was investigated. First, the effect of neonatal surgical castration was examined in a randomized, cross-sectional study in which male Wistar rats were allocated to be either castrated or sham-operated 4 h after birth. Then, the effect of prepubertal chemical castration was analysed in a second, randomized longitudinal study in which male Wistar rats were randomly allocated either to a control group or to two experimental groups, one injected with triptorelin at day 25 and the other injected on day 25 and on day 45. Every tenth day between 20 and 70 days of age for the first study, and between 30 and 110 days of age for the second, body length and weight were measured, cephalometric X-rays taken, and blood samples obtained. Neonatal and prepubertal castration resulted in decreased plasma concentrations of testosterone and in delayed growth of somatic and craniofacial components. The initiation, duration and magnitude of the effect was dependent on individual bones (cranial base, skull roof) and on the lower incisor, and related to the testosterone concentrations. These results suggest that testosterone effects participate in the process of normal craniofacial growth, particularly during puberty.
Disciplines :
Endocrinology, metabolism & nutrition
Author, co-author :
Verdonck, A.;  School of Dentistry, Department of Orthodontics, University Hospital St. Rafaël, Leuven, Belgium
De Ridder, L.;  School of Dentistry, Department of Orthodontics, University Hospital St. Rafaël, Leuven, Belgium
Verbeke, G.
Bourguignon, Jean-Pierre ;  Université de Liège - ULiège > Département des sciences cliniques > Département des sciences cliniques
Carels, C.;  School of Dentistry, Department of Orthodontics, University Hospital St. Rafaël, Leuven, Belgium
Kühn, E. R.
Darras, V.
De Zegher, F.
Language :
English
Title :
Comparative effects of neonatal and prepubertal castration on craniofacial growth in rats
Publication date :
1998
Journal title :
Archives of Oral Biology
ISSN :
0003-9969
Publisher :
Elsevier, United Kingdom
Volume :
43
Issue :
11
Pages :
861-871
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
FWO - Fonds Wetenschappelijk Onderzoek Vlaanderen [BE]
Ipsen Biotec
Commentary :
CC BY-NC-ND
Available on ORBi :
since 01 February 2021

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