Genome-wide expression reveals multiple systemic effects associated with detection of anticoagulant poisons in bobcats (Lynx rufus).

Fraser, Devaughn; Mouton, Alice; Serieys, Laurel E. K.; Cole, Steve; Carver, Scott; Vandewoude, Sue; Lappin, Michael; Riley, Seth P. D.; Wayne, Robert

doi:10.1111/mec.14531

Article (Scientific journals)

Genome-wide expression reveals multiple systemic effects associated with detection of anticoagulant poisons in bobcats (Lynx rufus).

Fraser, Devaughn; Mouton, Alice; Serieys, Laurel E. K. et al.

2018 • In Molecular Ecology, 27 (5), p. 1170-1187

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https://hdl.handle.net/2268/255833

DOI
10.1111/mec.14531

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29427407

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Keywords :

Adaptive Immunity/drug effects; Animals; Anticoagulants/toxicity; California; Disease Susceptibility/chemically induced; Endoplasmic Reticulum Stress; Environmental Exposure; Environmental Pollutants/toxicity; Food Chain; Gene Expression Profiling; Genome/drug effects; Immunity, Innate/drug effects; Lynx/genetics/metabolism; Principal Component Analysis; Rodenticides/toxicity; Xenobiotics/metabolism/toxicity; anticoagulant rodenticides; bobcats; gene expression; secondary poisoning

Abstract :

[en] Anticoagulant rodenticides (ARs) are indiscriminate toxicants that threaten nontarget predatory and scavenger species through secondary poisoning. Accumulating evidence suggests that AR exposure may have disruptive sublethal consequences on individuals that can affect fitness. We evaluated AR-related effects on genome-wide expression patterns in a population of bobcats in southern California. We identify differential expression of genes involved in xenobiotic metabolism, endoplasmic reticulum stress response, epithelial integrity and both adaptive and innate immune function. Further, we find that differential expression of immune-related genes may be attributable to AR-related effects on leucocyte differentiation. Collectively, our results provide an unprecedented understanding of the sublethal effects of AR exposure on a wild carnivore. These findings highlight potential detrimental effects of ARs on a wide variety of species worldwide that may consume poisoned rodents and indicate the need to investigate gene expression effects of other toxicants added to natural environments by humans.

Disciplines :

Zoology

Author, co-author :

Fraser, Devaughn ^✱

Mouton, Alice ^✱; University of California, Los Angeles - UCLA > Department of Ecology and Evolutionary Biology

Serieys, Laurel E. K.

Cole, Steve

Carver, Scott

Vandewoude, Sue

Lappin, Michael

Riley, Seth P. D.

Wayne, Robert

^✱ These authors have contributed equally to this work.

Language :

English

Title :

Genome-wide expression reveals multiple systemic effects associated with detection of anticoagulant poisons in bobcats (Lynx rufus).

Publication date :

2018

Journal title :

Molecular Ecology

ISSN :

0962-1083

eISSN :

1365-294X

Publisher :

Wiley, Oxford, United Kingdom

Volume :

Issue :

Pages :

1170-1187

Peer reviewed :

Peer Reviewed verified by ORBi

Commentary :

Available on ORBi :

since 26 January 2021

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