[en] Phytosterols (PSs) are insoluble in water and poorly soluble in oil, which hampers their potential as cholesterollevel regulator in human. To mitigate this problem, monoglycerides (MGs) were used to modulates the crys-tallization behavior of PSs. Therefore, the understanding on mixing behavior provides the insight into differentaspects of crystallization and the resultant effects. The effects on thermal, morphology, diffraction, and spec-troscopy behavior were investigated for binary mixtures of 11 different ratios (100:0 to 0:100 MGs:PSs). Thephase behavior of binary mixtures of commercial MGs and PSs exhibited complexity with the formation ofeutectic mixtures at 90:10 and 80:20 (MGs:PSs) combinations. These combinations revealed a single meltingprofile and reduced melting enthalpy, though after a month of storage at 5 °C. Conversely, two separate meltingregions were observed in others. Furthermore, powder X-ray diffraction (PXRD) analysis of selected combina-tions revealed a change in crystalline forms with changes in the peaks located between 18-19° (2θ) and 25-26°(2θ). Accordingly, Raman spectroscopy results revealed changes in intensities and peak shape. Therefore, thechange in crystalline forms or behavior correlated well to the change in thermal properties. Overall, the char-acterizations revealed the formation of eutectic mixtures between MGs and PSs at 90:10 and 80:20 (MGs:PSs) inwhich MGs modified the crystallization of PSs and changed the crystal forms thus, thermal behaviors. This studyprovides new insight into the mixing behavior of MGs and PSs which supports other research. Therefore, theresults of this study are beneficial for the improvement of formulation of phytosterols in food and pharma-ceutical products. Nonetheless, this study reveals a simple technique to alter crystal forms of phytosterolsthrough simple complexation with monoglycerides.
Disciplines :
Biotechnology
Author, co-author :
Bin Sintang, Mohd Dona
Danthine, Sabine ; Université de Liège - ULiège > Département GxABT > SMARTECH
Khalenkow, Dmitry
Tavernier, Iris
Tzompa Sosa, Daylan A.
Binti Julmohammad, Norliza
Van de Walle, Davy
Rimaux, Tom
Skirtach, Andre
Dewettinck, Koen
Language :
English
Title :
Modulating the crystallization of phytosterols with monoglycerides in the binary mixture systems: mixing behavior and eutectic formation
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