Modulating the crystallization of phytosterols with monoglycerides in the binary mixture systems: mixing behavior and eutectic formation

Bin Sintang, Mohd Dona; Danthine, Sabine; Khalenkow, Dmitry; Tavernier, Iris; Tzompa Sosa, Daylan A.; Binti Julmohammad, Norliza; Van de Walle, Davy; Rimaux, Tom; Skirtach, Andre; Dewettinck, Koen

doi:10.1016/j.chemphyslip.2020.104912

Article (Scientific journals)

Modulating the crystallization of phytosterols with monoglycerides in the binary mixture systems: mixing behavior and eutectic formation

Bin Sintang, Mohd Dona; Danthine, Sabine; Khalenkow, Dmitry et al.

2020 • In Chemistry and Physics of Lipids, 230 (104912)

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https://hdl.handle.net/2268/255171

DOI
10.1016/j.chemphyslip.2020.104912

PubMed
32371001

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Keywords :

Condensing effect, Sterols; Eutectic mixture; Phase behavior; Phytosterols; Monoglycerides

Abstract :

[en] Phytosterols (PSs) are insoluble in water and poorly soluble in oil, which hampers their potential as cholesterollevel regulator in human. To mitigate this problem, monoglycerides (MGs) were used to modulates the crys-tallization behavior of PSs. Therefore, the understanding on mixing behavior provides the insight into differentaspects of crystallization and the resultant effects. The effects on thermal, morphology, diffraction, and spec-troscopy behavior were investigated for binary mixtures of 11 different ratios (100:0 to 0:100 MGs:PSs). Thephase behavior of binary mixtures of commercial MGs and PSs exhibited complexity with the formation ofeutectic mixtures at 90:10 and 80:20 (MGs:PSs) combinations. These combinations revealed a single meltingprofile and reduced melting enthalpy, though after a month of storage at 5 °C. Conversely, two separate meltingregions were observed in others. Furthermore, powder X-ray diffraction (PXRD) analysis of selected combina-tions revealed a change in crystalline forms with changes in the peaks located between 18-19° (2θ) and 25-26°(2θ). Accordingly, Raman spectroscopy results revealed changes in intensities and peak shape. Therefore, thechange in crystalline forms or behavior correlated well to the change in thermal properties. Overall, the char-acterizations revealed the formation of eutectic mixtures between MGs and PSs at 90:10 and 80:20 (MGs:PSs) inwhich MGs modified the crystallization of PSs and changed the crystal forms thus, thermal behaviors. This studyprovides new insight into the mixing behavior of MGs and PSs which supports other research. Therefore, theresults of this study are beneficial for the improvement of formulation of phytosterols in food and pharma-ceutical products. Nonetheless, this study reveals a simple technique to alter crystal forms of phytosterolsthrough simple complexation with monoglycerides.

Disciplines :

Biotechnology

Author, co-author :

Bin Sintang, Mohd Dona

Danthine, Sabine ; Université de Liège - ULiège > Département GxABT > SMARTECH

Khalenkow, Dmitry

Tavernier, Iris

Tzompa Sosa, Daylan A.

Binti Julmohammad, Norliza

Van de Walle, Davy

Rimaux, Tom

Skirtach, Andre

Dewettinck, Koen

Language :

English

Title :

Modulating the crystallization of phytosterols with monoglycerides in the binary mixture systems: mixing behavior and eutectic formation

Publication date :

2020

Journal title :

Chemistry and Physics of Lipids

ISSN :

0009-3084

Publisher :

Elsevier, Netherlands

Volume :

230

Issue :

104912

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 15 January 2021

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