Metformin-Induced Lactic Acidosis : A question of Time

[en] Metformin is an oral antidiabetic largely prescribed in the treatment of type II diabetes. Overdose is associated with life-threatening lactic acidosis. We report the case of the highest metformin concentration ever described secondary to a voluntary suicidal intake. The patient developed a severe lactic acidosis and hemodynamic shock successfully treated with high-flow hemofiltration. Time to start extrarenal epuration is capital to avoid poor evolution.

Disciplines :

Pharmacy, pharmacology & toxicology

Author, co-author :

Bellefroid, Céline ; Centre Hospitalier Universitaire de Liège - CHU > Département d'Anesthésie et réanimation > Service d'anesthésie - réanimation

Goffin, Pierre; Centre Hospitalier Chrétien Liège > Department of Anesthesia and Intensive Care

Guntz, Julien; Centre Hospitalier Chrétien Liège > Department of Anesthesia and Intensive Care

DEVILLE, Marine ; Centre Hospitalier Universitaire de Liège - CHU > Unilab > Laboratoire toxicologie clinique

Language :

English

Title :

Metformin-Induced Lactic Acidosis : A question of Time

Publication date :

2020

Journal title :

Case Reports in Critical Care

ISSN :

2090-6420

eISSN :

2090-6439

Publisher :

Hindawi Limited, United Kingdom

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

https://doi.org/10.1155/2020/6962591

Available on ORBi :

since 13 January 2021

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