Relationship between brain AD biomarkers and episodic memory performance in healthy aging

Rizzolo, Lou; Narbutas, Justinas; Van Egroo, Maxime; Chylinski, Daphné; Besson, Gabriel; Baillet, Marion; Bahri, Mohamed Ali; Salmon, Eric; Maquet, Pierre; Vandewalle, Gilles; Bastin, Christine; Collette, Fabienne

doi:10.1016/j.bandc.2020.105680

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Relationship between brain AD biomarkers and episodic memory performance in healthy aging

Rizzolo, Lou; Narbutas, Justinas; Van Egroo, Maxime et al.

2021 • In Brain and Cognition, 148, p. 105680

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https://hdl.handle.net/2268/254862

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10.1016/j.bandc.2020.105680

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33418512

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Disciplines :

Neurosciences & behavior

Author, co-author :

Rizzolo, Lou ; Université de Liège - ULiège > CRC In vivo Imaging-Sleep and chronobiology

Narbutas, Justinas ; Université de Liège - ULiège > Département de Psychologie > Neuropsychologie

Van Egroo, Maxime

Chylinski, Daphné ; Université de Liège - ULiège > CRC In vivo Imaging-Sleep and chronobiology

Besson, Gabriel ; Université de Liège - ULiège > CRC In vivo Imaging-Aging & Memory

Baillet, Marion ; Université de Liège - ULiège > GIGA CRC In vivo Imaging

Bahri, Mohamed Ali ; Université de Liège - ULiège > CRC In vivo Imaging-Aging & Memory

Salmon, Eric ; Université de Liège - ULiège > Département des sciences cliniques > Neuroimagerie des troubles de la mémoire et revalid. cogn.

Maquet, Pierre ; Université de Liège - ULiège > Département des sciences cliniques > Neurologie

Vandewalle, Gilles ; Université de Liège - ULiège > CRC In vivo Imaging-Sleep and chronobiology

Bastin, Christine ; Université de Liège - ULiège > CRC In vivo Imaging-Aging & Memory

Collette, Fabienne ; Université de Liège - ULiège > Département de Psychologie > Neuropsychologie

Language :

English

Title :

Relationship between brain AD biomarkers and episodic memory performance in healthy aging

Publication date :

2021

Journal title :

Brain and Cognition

ISSN :

0278-2626

eISSN :

1090-2147

Publisher :

Elsevier, Atlanta, United States - New York

Volume :

148

Pages :

105680

Peer reviewed :

Peer Reviewed verified by ORBi

Name of the research project :

SLEEPDEM

Funders :

FWB - Fédération Wallonie-Bruxelles

Funding text :

This work was supported by Fonds National de la Recherche Scientifique (FRS-FNRS, FRSM 3.4516.11, MEMODYN 30446199, Belgium), the Wallonia-Brussels Federation (grant for Concerted Research Actions – SLEEPDEM), University of Liege, Fondation Simone et Pierre Clerdent, European Regional Development Fund (ERDF, Radiomed Project). J.N. was supported by University of Li`ege. M.V.E., C.S., C.B., G.V., F.C. were supported by the FNRS-Belgium. [18F]Flutemetamol doses were provided and cost covered by GE Healthcare Ltd (Little Chalfont, UK) as part of an investigator sponsored study (ISS290) agreement. This agreement had no influence on the protocol and results of the study reported here. None of funding sources had an involvement in study design; in the collection, analysis, interpretation of data; in the writing of the report; in the decision to submit the article for publication.

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Bibliography

Albert, M.S., The ageing brain: Normal and abnormal memory. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences 352 (1997), 1703–1709.
Aschenbrenner, A.J., Gordon, B.A., Benzinger, T.L.S., Morris, J.C., Hassenstab, J.J., Influence of tau PET, amyloid PET, and hippocampal volume on cognition in Alzheimer disease. Neurology 91 (2018), e859–e866.
Ashburner, J., A fast diffeomorphic image registration algorithm. Neuroimage 38 (2007), 95–113.
Ashburner, J., Friston, K.J., Unified segmentation. Neuroimage 26 (2005), 839–851.
Battle, M.R., Pillay, L.C., Lowe, V.J., Knopman, D., Kemp, B., Rowe, C.C., Buckley, C.J., Centiloid scaling for quantification of brain amyloid with [18F]flutemetamol using multiple processing methods. EJNMMI Research, 8, 2018, 107.
Beck, A.T., 1961. An Inventory for Measuring Depression. Arch Gen Psychiatry. 4:561.
Beck, A.T., Epstein, N., Brown, G., Steer, R.A., An inventory for measuring clinical anxiety: Psychometric properties. Journal of Consulting and Clinical Psychology 56 (1988), 893–897.
Berron, D., Cardenas-Blanco, A., Bittner, D., Metzger, C.D., Spottke, A., Heneka, M.T., Düzel, E., Higher CSF tau levels are related to hippocampal hyperactivity and object mnemonic discrimination in older adults. Journal of Neuroscience 39 (2019), 8788–8797.
Braak, H., Braak, E., Neuropathological stageing of Alzheimer-related changes. Acta Neuropathologica 82 (1991), 239–259.
Braak, H., Braak, E., Staging of alzheimer's disease-related neurofibrillary changes. Neurobiology of Aging 16 (1995), 271–278.
Braak, H., Del Tredici, K., The preclinical phase of the pathological process underlying sporadic Alzheimer's disease. Brain. 138 (2015), 2814–2833.
Brickman, A.M., Stern, Y., Aging and Memory in Humans. Encyclopedia of Neuroscience, 2009, Elsevier, 175–180.
Buckner, R.L., Molecular, structural, and functional characterization of Alzheimer's disease: Evidence for a relationship between default activity, amyloid, and memory. Journal of Neuroscience 25 (2005), 7709–7717.
Charlton, R.A., Barrick, T.R., Markus, H.S., Morris, R.G., The relationship between episodic long-term memory and white matter integrity in normal aging. Neuropsychologia 48 (2010), 114–122.
Chiotis, K., Stenkrona, P., Almkvist, O., Stepanov, V., Ferreira, D., Arakawa, R., Nordberg, A., Dual tracer tau PET imaging reveals different molecular targets for 11C-THK5351 and 11C-PBB3 in the Alzheimer brain. European Journal of Nuclear Medicine and Molecular Imaging 45 (2018), 1605–1617.
Clark, L.R., Racine, A.M., Koscik, R.L., Okonkwo, O.C., Engelman, C.D., Carlsson, C.M., Johnson, S.C., Beta-amyloid and cognitive decline in late middle age: Findings from the Wisconsin Registry for Alzheimer's Prevention study. Alzheimer's Dement. 12 (2016), 805–814.
Craik, F.I.M., McDowd, J.M., Age differences in recall and recognition. Journal of Experimental Psychology. Learning, Memory, and Cognition 13 (1987), 474–479.
Davidson, P.S.R., Vidjen, P., Trincao-Batra, S., Collin, C.A., Older Adults’ lure discrimination difficulties on the mnemonic similarity task are significantly correlated with their visual perception. Journals Gerontol Ser B., XX:1–10, 2018.
Dillon, S.E., Tsivos, D., Knight, M., McCann, B., Pennington, C., Shiel, A.I., Coulthard, E.J., The impact of ageing reveals distinct roles for human dentate gyrus and CA3 in pattern separation and object recognition memory. Scientific Reports, 7, 2017, 14069.
Farrell, M.E., Kennedy, K.M., Rodrigue, K.M., Wig, G., Bischof, G.N., Rieck, J.R., Park, D.C., Association of longitudinal cognitive decline with amyloid burden in middle-aged and older adults. JAMA Neurol, 74, 2017, 830.
Foster, C.M., Giovanello, K.S., Domain general processes moderate age-related performance differences on the mnemonic similarity task. Memory 28 (2020), 528–536.
Gorbach, T., Pudas, S., Lundquist, A., Orädd, G., Josefsson, M., Salami, A., Nyberg, L., Longitudinal association between hippocampus atrophy and episodic-memory decline. Neurobiology of Aging 51 (2017), 167–176.
Hanseeuw, B.J., Betensky, R.A., Jacobs, H.I.L., Schultz, A.P., Sepulcre, J., Becker, J.A., Johnson, K., Association of amyloid and tau with cognition in preclinical alzheimer disease. JAMA Neurol, 76, 2019, 915.
Harada, R., Ishiki, A., Kai, H., Sato, N., Furukawa, K., Furumoto, S., Okamura, N., Correlations of 18 F-THK5351 PET with Postmortem Burden of Tau and Astrogliosis in Alzheimer Disease. Journal of Nuclear Medicine 59 (2018), 671–674.
Hedden, T., Oh, H., Younger, A.P., Patel, T.A., Meta-analysis of amyloid-cognition relations in cognitively normal older adults. Neurology. 80 (2013), 1341–1348.
Holden, H.M., Toner, C., Pirogovsky, E., Kirwan, C.B., Gilbert, P.E., Visual object pattern separation varies in older adults. Learning & Memory 20 (2013), 358–362.
Ishiki, A., Harada, R., Kai, H., Sato, N., Totsune, T., Tomita, N., Arai, H., Neuroimaging-pathological correlations of [18F]THK5351 PET in progressive supranuclear palsy. Acta Neuropathologica Communications, 6, 2018, 53.
Jack, C.R., Knopman, D.S., Jagust, W.J., Petersen, R.C., Weiner, M.W., Aisen, P.S., Trojanowski, J.Q., Tracking pathophysiological processes in Alzheimer's disease: An updated hypothetical model of dynamic biomarkers. Lancet Neurology 12 (2013), 207–216.
Jack, C.R., Knopman, D.S., Jagust, W.J., Shaw, L.M., Aisen, P.S., Weiner, M.W., Trojanowski, J.Q., Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade. Lancet Neurology 9 (2010), 119–128.
Jaeger, B.C., Edwards, L.J., Das, K., Sen, P.K., An R 2 statistic for fixed effects in the generalized linear mixed model. Journal of Applied Statistics 44 (2017), 1086–1105.
Jang, Y.K., Lyoo, C.H., Park, S., Oh, S.J., Cho, H., Oh, M., Seo, S.W., Head to head comparison of [18F] AV-1451 and [18F] THK5351 for tau imaging in Alzheimer's disease and frontotemporal dementia. European Journal of Nuclear Medicine and Molecular Imaging 45 (2018), 432–442.
Johnson, S.C., Christian, B.T., Okonkwo, O.C., Oh, J.M., Harding, S., Xu, G., Sager, M.A., Amyloid burden and neural function in people at risk for Alzheimer's Disease. Neurobiology of Aging 35 (2014), 576–584.
Kaup, A.R., Mirzakhanian, H., Jeste, D.V., Eyler, L.T., A review of the brain structure correlates of successful cognitive aging. Journal of Neuropsychiatry 23 (2011), 6–15.
Klunk, W.E., Koeppe, R.A., Price, J.C., Benzinger, T.L., Devous, M.D., Jagust, W.J., Mintun, M.A., The Centiloid project: Standardizing quantitative amyloid plaque estimation by PET. Alzheimer's Dement 11 (2015), 1–15.e4.
Kwak, S., Kim, H., Chey, J., Youm, Y., Feeling how old I am: subjective age is associated with estimated brain age. Frontiers in Aging Neuroscience, 10, 2018.
Leal, S.L., Lockhart, S.N., Maass, A., Bell, R.K., Jagust, W.J., Subthreshold amyloid predicts tau deposition in aging. Journal of Neuroscience 38 (2018), 4482–4489.
Levine, M., Ensom, M.H.H., Post hoc power analysis: an idea whose time has passed?. Pharmacother Off J Am Coll Clin Pharm. 21 (2001), 405–409.
Lockhart, S.N., Baker, S.L., Okamura, N., Furukawa, K., Ishiki, A., Furumoto, S., Jagust, W.J., Dynamic PET measures of tau accumulation in cognitively normal older adults and Alzheimer's disease patients measured using [18F] THK-5351. PLoS ONE, 11, 2016, e0158460.
Maass, A., Landau, S., Baker, S.L., Horng, A., Lockhart, S.N., La Joie, R., Jagust, W.J., Comparison of multiple tau-PET measures as biomarkers in aging and Alzheimer's disease. Neuroimage 157 (2017), 448–463.
Maass, A., Lockhart, S.N., Harrison, T.M., Bell, R.K., Mellinger, T., Swinnerton, K., Jagust, W.J., Entorhinal tau pathology, episodic memory decline, and neurodegeneration in aging. Journal of Neuroscience 38 (2018), 530–543.
Marks, S.M., Lockhart, S.N., Baker, S.L., Jagust, W.J., Tau and β-amyloid are associated with medial temporal lobe structure, function, and memory encoding in normal aging. Journal of Neuroscience 37 (2017), 3192–3201.
McKhann, G.M., Knopman, D.S., Chertkow, H., Hyman, B.T., Jack, C.R., Kawas, C.H., Phelps, C.H., The diagnosis of dementia due to Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimer's Dement 7 (2011), 263–269.
Mielke, M.M., Machulda, M.M., Hagen, C.E., Christianson, T.J., Roberts, R.O., Knopman, D.S., Petersen, R.C., Influence of amyloid and APOE on cognitive performance in a late middle-aged cohort. Alzheimer's Dement 12 (2016), 281–291.
Mormino, E.C., Kluth, J.T., Madison, C.M., Rabinovici, G.D., Baker, S.L., Miller, B.L., Jagust, W.J., Episodic memory loss is related to hippocampal-mediated -amyloid deposition in elderly subjects. Brain 132 (2009), 1310–1323.
Mormino E. C., Smiljic A., Hayenga A.O., H. Onami S,. Greicius M.D., Rabinovici G.D., Janabi M., Baker S.L., V. Yen I., Madison C.M., Miller B.L., Jagust W.J., 2011. Relationships between Beta-Amyloid and Functional Connectivity in Different Components of the Default Mode Network in Aging. Cereb Cortex. 21:2399–2407.
Murugan, N.A., Chiotis, K., Rodriguez-Vieitez, E., Lemoine, L., Ågren, H., Nordberg, A., Cross-interaction of tau PET tracers with monoamine oxidase B: Evidence from in silico modelling and in vivo imaging. European Journal of Nuclear Medicine and Molecular Imaging 46 (2019), 1369–1382.
Navitsky, M., Joshi, A.D., Kennedy, I., Klunk, W.E., Rowe, C.C., Wong, D.F., Devous, M.D., Standardization of amyloid quantitation with florbetapir standardized uptake value ratios to the Centiloid scale. Alzheimer's Dement 14 (2018), 1565–1571.
Neth, B. J., Graff-Radford, J., Mielke, M.M., Przybelski, S.A., Lesnick T.G., Schwarz C. G, & …, Vemuri, P. (2020). Relationship between risk factors and brain reserve in late middle age: implications for cognitive aging. Frontiers in Aging Neuroscience 11, 1–11.
Nyberg, L., Maitland, S.B., Rönnlund, M., Bäckman, L., Dixon, R.A., Wahlin, Å., Nilsson, L.-G., Selective adult age differences in an age-invariant multifactor model of declarative memory. Psychology and Aging 18 (2003), 149–160.
O'Shea, A., Cohen, R.A., Porges, E.C., Nissim, N.R., Woods, A.J., Cognitive aging and the hippocampus in older adults. Frontiers in Aging Neuroscience 8 (2016), 1–8.
Okonkwo, O.C., Oh, J.M., Koscik, R., Jonaitis, E., Cleary, C.A., Dowling, N.M., Johnson, S.C., Amyloid burden, neuronal function, and cognitive decline in middle-aged adults at risk for Alzheimer's disease. Journal of the International Neuropsychological Society 20 (2014), 422–433.
Palmqvist, S., Schöll, M., Strandberg, O., Mattsson, N., Stomrud, E., Zetterberg, H., Hansson, O., Earliest accumulation of β-amyloid occurs within the default-mode network and concurrently affects brain connectivity. Nature Communications, 8, 2017, 1214.
Paul, R., Lane, E.M., Tate, D.F., Heaps, J., Romo, D.M., Akbudak, E., Conturo, T.E., Neuroimaging signatures and cognitive correlates of the montreal cognitive assessment screen in a nonclinical elderly sample. Archives of Clinical Neuropsychology 26 (2011), 454–460.
Pereira, J.B., Ossenkoppele, R., Palmqvist, S., Strandberg, T.O., Smith, R., Westman, E., Hansson, O., Amyloid and tau accumulate across distinct spatial networks and are differentially associated with brain connectivity. Elife. 8 (2019), 1–25.
Pishdadian, S., Hoang, N.V., Baker, S., Moscovitch, M., Rosenbaum, R.S., Not only memory: Investigating the sensitivity and specificity of the Mnemonic Similarity Task in older adults. Neuropsychologia., 149, 2020, 107670.
Racine, A.M., Koscik, R.L., Berman, S.E., Nicholas, C.R., Clark, L.R., Okonkwo, O.C., Johnson, S.C., Biomarker clusters are differentially associated with longitudinal cognitive decline in late midlife. Brain. 139 (2016), 2261–2274.
Reagh, Z.M., Noche, J.A., Tustison, N.J., Delisle, D., Murray, E.A., Yassa, M.A., Functional imbalance of anterolateral entorhinal cortex and hippocampal dentate/CA3 underlies age-related object pattern separation deficits. Neuron 97 (2018), 1187–1198.e4.
Rönnlund, M., Nyberg, L., Bäckman, L., Nilsson, L.-G., Stability, growth, and decline in adult life span development of declarative memory: Cross-sectional and longitudinal data from a population-based study. Psychology and Aging 20 (2005), 3–18.
Rugg, M.D., Vilberg, K.L., Brain networks underlying episodic memory retrieval. Current Opinion in Neurobiology 23 (2013), 255–260.
Salvadó, G., Molinuevo, J.L., Brugulat-Serrat, A., Falcon, C., Grau-Rivera, O., Suárez-Calvet, M., Gispert, J.D., Centiloid cut-off values for optimal agreement between PET and CSF core AD biomarkers. Alzheimers Res Ther., 11, 2019, 27.
Sarazin, M., Berr, C., De Rotrou, J., Fabrigoule, C., Pasquier, F., Legrain, S., Dubois, B., Amnestic syndrome of the medial temporal type identifies prodromal AD: A longitudinal study. Neurology 69 (2007), 1859–1867.
Schindler, S.E., Jasielec, M.S., Weng, H., Hassenstab, J.J., Grober, E., McCue, L.M., Fagan, A.M., Neuropsychological measures that detect early impairment and decline in preclinical Alzheimer disease. Neurobiology of Aging 56 (2017), 25–32.
Schöll, M., Lockhart, S.N., Schonhaut, D.R., O'Neil, J.P., Janabi, M., Ossenkoppele, R., Jagust, W.J., PET Imaging of Tau Deposition in the Aging Human Brain. Neuron 89 (2016), 971–982.
Song, Z., Insel, P.S., Buckley, S., Yohannes, S., Mezher, A., Simonson, A., Weiner, M.W., Brain amyloid- burden is associated with disruption of intrinsic functional connectivity within the medial temporal lobe in cognitively normal elderly. Journal of Neuroscience 35 (2015), 3240–3247.
Stark, S.M., Kirwan, C.B., Stark, C.E.L., Mnemonic similarity task: A tool for assessing hippocampal integrity. Trends in Cognitive Sciences 23 (2019), 938–951.
Stark, S.M., Stark, C.E.L., Age-related deficits in the mnemonic similarity task for objects and scenes. Behavioural Brain Research 333 (2017), 109–117.
Stark, S.M., Stevenson, R., Wu, C., Rutledge, S., Stark, C.E.L., Stability of age-related deficits in the mnemonic similarity task across task variations. Behavioral Neuroscience 129 (2015), 257–268.
Stark, S.M., Yassa, M.A., Lacy, J.W., Stark, C.E.L., A task to assess behavioral pattern separation (BPS) in humans: Data from healthy aging and mild cognitive impairment. Neuropsychologia. 51 (2013), 2442–2449.
Stern, Y., What is cognitive reserve? Theory and research application of the reserve concept. Journal of the International Neuropsychological Society 8 (2002), 448–460.
Svenningsson, A.L., Stomrud, E., Insel, P.S., Mattsson, N., Palmqvist, S., Hansson, O., β-amyloid pathology and hippocampal atrophy are independently associated with memory function in cognitively healthy elderly. Scientific Reports, 9, 2019, 11180.
Tabelow, K., Balteau, E., Ashburner, J., Callaghan, M.F., Draganski, B., Helms, G., Mohammadi, S., hMRI – A toolbox for quantitative MRI in neuroscience and clinical research. Neuroimage. 194 (2019), 191–210.
Terrera, G.M., Harrison, J.E., Ritchie, C.W., Ritchie, K., Cognitive functions as predictors of Alzheimer's disease biomarker status in the European prevention of Alzheimer's dementia cohort. Journal of Alzheimer's Disease. 74 (2020), 1203–1210.
Thal, D.R., Rüb, U., Orantes, M., Braak, H., Phases of Aβ-deposition in the human brain and its relevance for the development of AD. Neurology 58 (2002), 1791–1800.
Toner, C.K., Pirogovsky, E., Kirwan, C.B., Gilbert, P.E., Visual object pattern separation deficits in nondemented older adults. Learning & Memory 16 (2009), 338–342.
Tromp, D., Dufour, A., Lithfous, S., Pebayle, T., Després, O., Episodic memory in normal aging and Alzheimer disease: Insights from imaging and behavioral studies. Ageing Research Reviews 24 (2015), 232–262.
Van der Linden. M, Coyette. F, Poitrenaud. J, Kalafat. M, Calicis. F WC. 2004. L’épreuve de rappel libre/rappel indicé à 16 items (RL/RI). In: Van der Linden M, Adam S, Agniel A, Baisset-Mouly C et les membres du GREMEM. (Eds.) L’évaluation des troubles de la mémoire: présentation de quatre tests de mémoire épisodique (avec leur étalonnage). Solal. ed. Marseille. p. 25–47.
Van Egroo, M., Narbutas, J., Chylinski, D., Villar González, P., Ghaemmaghami, P., Muto, V., Vandewalle, G., Preserved wake-dependent cortical excitability dynamics predict cognitive fitness beyond age-related brain alterations. Communications Biology, 2, 2019, 449.
Van Petten, C., Relationship between hippocampal volume and memory ability in healthy individuals across the lifespan: Review and meta-analysis. Neuropsychologia. 42 (2004), 1394–1413.
Vuoksimaa, E., Panizzon, M.S., Chen, C., Eyler, L.T., Fennema-Notestine, C., Fiecas, M.J.A., Kremen, W.S., Cognitive reserve moderates the association between hippocampal volume and episodic memory in middle age. Neuropsychologia. 51 (2013), 1124–1131.
Wechsler, D., Stone, C.P., Wechsler Memory Scale-revised. 1987, Psychological Corporation, San Antonio.
Weiskopf, N., Helms, G., Multi-parameter mapping of the human brain at 1mm resolution in less than 20 minutes. Proceedings of the International Society for Magnetic Resonance in Medicine, 16, 2008, 2241.
Yassa, M.A., Lacy, J.W., Stark, S.M., Albert, M.S., Gallagher, M., Stark, C.E.L., Pattern separation deficits associated with increased hippocampal CA3 and dentate gyrus activity in nondemented older adults. Hippocampus., 21, 2010 n/a-n/a.
Yassa, M.A., Stark, C.E.L., Pattern separation in the hippocampus. Trends in Neurosciences 34 (2011), 515–525.
Yeung, L.-K., Olsen, R.K., Bild-Enkin, H.E.P., D'Angelo, M.C., Kacollja, A., McQuiggan, D.A., Barense, M.D., Anterolateral entorhinal cortex volume predicted by altered intra-item configural processing. Journal of Neuroscience 37 (2017), 5527–5538.
Yushkevich, P.A., Pluta, J.B., Wang, H., Xie, L., Ding, S.-L., Gertje, E.C., Wolk, D.A., Automated volumetry and regional thickness analysis of hippocampal subfields and medial temporal cortical structures in mild cognitive impairment. Human Brain Mapping 36 (2015), 258–287.