Article (Scientific journals)
Predictors of Mortality and Effect of Drug Therapies in Mechanically Ventilated Patients With Coronavirus Disease 2019: A Multicenter Cohort Study
Lambermont, Bernard; Ernst, Marie; Demaret, Pierre et al.
2020In Critical Care Explorations, 2 (12), p. 0305
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Keywords :
coronavirus
Abstract :
[en] We conducted a multicenter cohort study to determine the effect of drug therapies on survival in mechanically ventilated patients with coronavirus disease 2019. All consecutive adult patients admitted to ICU for coronavirus disease 2019 from March 1, 2020, to April 25, 2020, and under invasive mechanical ventilation for more than 24 hours were included. Out of 2,003 patients hospitalized for coronavirus disease 2019, 361 were admitted to ICU, 257 were ventilated for more than 24 hours, and 247 were included in the study. Simple and multiple time-dependent Cox regression models were used to assess the effects of factors on survival. Methylprednisolone administration during the first week of mechanical ventilation was associated with a decrease in mortality rate from 48% to 34% (p = 0.01). Mortality was significantly associated with older age, higher creatinine, lower lymphocyte count, and mean arterial pressure lower than 70 mm Hg on the day of admission.
Disciplines :
Anesthesia & intensive care
Author, co-author :
Lambermont, Bernard  ;  Université de Liège - ULiège > Département des sciences cliniques > Département des sciences cliniques
Ernst, Marie  ;  Centre Hospitalier Universitaire de Liège - CHU > Département de gestion des systèmes d'informations (GSI) > Secteur d'appui à la recherche clinique et biostatistique
Demaret, Pierre
Boccar, Sandrine 
Gurdebeke, Christine
Cedric, Van Brussel
Quinonez, Manuel
Dubois, Christophe
Lemineur, Thierry
Njambou, Thierry
Akando, Benoit
Wertz, Damien
Higny, Julien
Misset, Benoît ;  Université de Liège - ULiège > Département des sciences cliniques > Soins intensifs
More authors (5 more) Less
Language :
English
Title :
Predictors of Mortality and Effect of Drug Therapies in Mechanically Ventilated Patients With Coronavirus Disease 2019: A Multicenter Cohort Study
Publication date :
2020
Journal title :
Critical Care Explorations
eISSN :
2639-8028
Publisher :
Wolters Kluwer Health, Philadelphia, United States - Pennsylvania
Volume :
2
Issue :
12
Pages :
e0305
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 07 January 2021

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