A G3P[13] porcine group A rotavirus emerging in China is a reassortant and a natural recombinant in the VP4 gene

[en] Group A rotaviruses (RVAs) are a major cause of serious intestinal disease in piglets. In this study, a novel pig strain was identified in a stool sample from China. The strain was designated RVA/Pig/China/LNCY/2016/G3P[13] and had a G3-P[13]-I5-R1-C1-M1-A8-N1-T1-E1-H1 genome. The viral protein 7 (VP7) and non-structural protein 4 (NSP4) genes of RVA/Pig/China/LNCY/2016/G3P[13] were closely related to cogent genes of human RVAs, suggesting that a reassortment between pig and human strains had occurred. Recombination analysis showed that RVA/Pig/China/LNCY/2016/G3P[13] is a natural recombinant strain between the P[23] and P[7] RVA strains, and crossover points for recombination were found at nucleotides (nt) 456 and 804 of the VP4 gene. Elucidating the biological characteristics of porcine rotavirus (PoRV) will be helpful for further analyses of the epidemic characteristics of this virus. The results of this study provide valuable information for RVA recombination and evolution and will facilitate future investigations into the molecular pathogenesis of RVAs. © 2017 Blackwell Verlag GmbH.

Disciplines :

Veterinary medicine & animal health

Author, co-author :

Jing, Z.; Division of Swine Infectious Diseases State Key Laboratory of Veterinary Biotechnology Harbin Veterinary Research Institute of the Chinese Academy of Agricultural Sciences Harbin China

Zhang, X.; Division of Swine Infectious Diseases State Key Laboratory of Veterinary Biotechnology Harbin Veterinary Research Institute of the Chinese Academy of Agricultural Sciences Harbin China

Shi, H.; Division of Swine Infectious Diseases State Key Laboratory of Veterinary Biotechnology Harbin Veterinary Research Institute of the Chinese Academy of Agricultural Sciences Harbin China

Chen, J.; Division of Swine Infectious Diseases State Key Laboratory of Veterinary Biotechnology Harbin Veterinary Research Institute of the Chinese Academy of Agricultural Sciences Harbin China

Shi, D.; Division of Swine Infectious Diseases State Key Laboratory of Veterinary Biotechnology Harbin Veterinary Research Institute of the Chinese Academy of Agricultural Sciences Harbin China

Dong, Hui ; Université de Liège - ULiège > Doct. sc. agro. & ingé. biol. (Paysage)

Feng, L.; Division of Swine Infectious Diseases State Key Laboratory of Veterinary Biotechnology Harbin Veterinary Research Institute of the Chinese Academy of Agricultural Sciences Harbin China

Language :

English

Title :

A G3P[13] porcine group A rotavirus emerging in China is a reassortant and a natural recombinant in the VP4 gene

Publication date :

2018

Journal title :

Transboundary and Emerging Diseases

ISSN :

1865-1674

eISSN :

1865-1682

Publisher :

Blackwell Publishing Ltd

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 26 December 2020

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