[en] The mitochondrial shaping protein Optic Atrophy 1 (OPA1)
controls angiogenesis, lymphangiogenesis and tumor growth
Stephanie Herkenne, Post doc, Padua, Italy
Stephanieherkenne@gmail.com
Mitochondria not only synthesize most of the cellular ATP, but they are
also centrally placed in intermediate metabolism Ca2+ signaling,
redox homeostasis and apoptosis. The multifunctional inner
mitochondrial membrane mitochondrial fusion protein Optic Atrophy 1
(OPA-1) is placed at the crossroad of fusion, cristae biogenesis,
metabolism, apoptosis and regulation of cardiomyocyte differentiation,
yet the role of mitochondrial dynamics in angiogenesis, the
physiological process through which new blood vessels form from preexisting ones, has not been addressed. Here we show that Opa1 is a
crucial component of the angiogenetic program. Upon endothelial cells
angiogenic stimulation, mitochondria elongate and OPA-1 level
increase. Genetic Opa1 ablation signals retrogradely from
mitochondria to the nucleus to modify angiogenic genes expression
and therefore inhibit all features of angiogenesis. Conditional Opa1
ablation substantiates its role in mouse and zebrafish angiogenesis
and in lymphangiogenesis mediated tumor metastatization. Thus,
Opa1-dependent mitochondrial dynamics is a targetable component of
angiogenesis.
