Hamasaki M, et al. (2013) Autophagosomes form at ER-mitochondria contact sites. Nature 495(7441):389-393.
Muñoz JP, et al. (2013) Mfn2 modulates the UPR and mitochondrial function via repression of PERK. EMBO J 32(17):2348-2361.
Szalai G, Krishnamurthy R, Hajnóczky G (1999) Apoptosis driven by IP(3)-linked mitochondrial calcium signals. EMBO J 18(22):6349-6361.
Rizzuto R, Brini M, Murgia M, Pozzan T (1993) Microdomains with high Ca2+ close to IP3-sensitive channels that are sensed by neighboring mitochondria. Science 262(5134):744-747.
Rizzuto R, et al. (1998) Close contacts with the endoplasmic reticulum as determinants of mitochondrial Ca2+ responses. Science 280(5370):1763-1766.
Hailey DW, et al. (2010) Mitochondria supply membranes for autophagosome biogenesis during starvation. Cell 141(4):656-667.
Csordás G, et al. (2006) Structural and functional features and significance of the physical linkage between ER and mitochondria. J Cell Biol 174(7):915-921.
Simmen T, et al. (2005) PACS-2 controls endoplasmic reticulum-mitochondria communication and Bid-mediated apoptosis. EMBO J 24(4):717-729.
Szabadkai G, et al. (2006) Chaperone-mediated coupling of endoplasmic reticulum and mitochondrial Ca2+ channels. J Cell Biol 175(6):901-911.
de Brito OM, Scorrano L (2008) Mitofusin 2 tethers endoplasmic reticulum to mitochondria. Nature 456(7222):605-610.
Giacomello M, et al. (2010) Ca2+ hot spots on the mitochondrial surface are generated by Ca2+ mobilization from stores, but not by activation of store-operated Ca2+ channels. Mol Cell 38(2):280-290.
Csordás G, et al. (2010) Imaging interorganelle contacts and local calcium dynamics at the ER-mitochondrial interface. Mol Cell 39(1):121-132.
Chen Y, et al. (2012) Mitofusin 2-containing mitochondrial-reticular microdomains direct rapid cardiomyocyte bioenergetic responses via interorganelle Ca(2+) crosstalk. Circ Res 111(7):863-875.
Schneeberger M, et al. (2013) Mitofusin 2 in POMC neurons connects ER stress with leptin resistance and energy imbalance. Cell 155(1):172-187.
Sebastián D, et al. (2012) Mitofusin 2 (Mfn2) links mitochondrial and endoplasmic reticulum function with insulin signaling and is essential for normal glucose homeostasis. Proc Natl Acad Sci USA 109(14):5523-5528.
Sugiura A, et al. (2013) MITOL regulates endoplasmic reticulum-mitochondria contacts via Mitofusin2. Mol Cell 51(1):20-34.
Wasilewski M, et al. (2012) Optic atrophy 1-dependent mitochondrial remodeling controls steroidogenesis in trophoblasts. Curr Biol 22(13):1228-1234.
Area-Gomez E, et al. (2012) Upregulated function of mitochondria-associated ER membranes in Alzheimer disease. EMBO J 31(21):4106-4123.
Daniele T, et al. (2014) Mitochondria and melanosomes establish physical contacts modulated by Mfn2 and involved in organelle biogenesis. Curr Biol 24(4):393-403.
Sandoval H, et al. (2014) Mitochondrial fusion but not fission regulates larval growth and synaptic development through steroid hormone production. eLife 3:e03558.
Rojo M, Legros F, Chateau D, Lombès A (2002) Membrane topology and mitochondrial targeting of mitofusins, ubiquitous mammalian homologs of the transmembrane GTPase Fzo. J Cell Sci 115(Pt 8):1663-1674.
Kornmann B, et al. (2009) An ER-mitochondria tethering complex revealed by a synthetic biology screen. Science 325(5939):477-481.
Lahiri S, et al. (2014) A conserved endoplasmic reticulum membrane protein complex (EMC) facilitates phospholipid transfer from the ER to mitochondria. PLoS Biol 12(10):e1001969.
Debattisti V, Pendin D, Ziviani E, Daga A, Scorrano L (2014) Reduction of endoplasmic reticulum stress attenuates the defects caused by Drosophila mitofusin depletion. J Cell Biol 204(3):303-312.
Cosson P, Marchetti A, Ravazzola M, Orci L (2012) Mitofusin-2 independent juxtaposition of endoplasmic reticulum and mitochondria: An ultrastructural study. PLoS One 7(9):e46293.
Filadi R, et al. (2015) Mitofusin 2 ablation increases endoplasmic reticulum-mitochondria coupling. Proc Natl Acad Sci USA 112(17):E2174-E2181.
Alford SC, Ding Y, Simmen T, Campbell RE (2012) Dimerization-dependent green and yellow fluorescent proteins. ACS Synth Biol 1(12):569-575.
Sood A, et al. (2014) A Mitofusin-2-dependent inactivating cleavage of Opa1 links changes in mitochondria cristae and ER contacts in the postprandial liver. Proc Natl Acad Sci USA 111(45):16017-16022.
Bucha S, Mukhopadhyay D, Bhattacharyya NP (2015) Regulation of mitochondrial morphology and cell cycle by microRNA-214 targeting Mitofusin2. Biochem Biophys Res Commun 465(4):797-802.
Chen H, et al. (2010) Mitochondrial fusion is required for mtDNA stability in skeletal muscle and tolerance of mtDNA mutations. Cell 141(2):280-289.
Kamer KJ, Mootha VK (2015) The molecular era of the mitochondrial calcium uniporter. Nat Rev Mol Cell Biol 16(9):545-553.
Kasahara A, Cipolat S, Chen Y, Dorn GW, 2nd, Scorrano L (2013) Mitochondrial fusion directs cardiomyocyte differentiation via calcineurin and Notch signaling. Science 342(6159):734-737.
Chen Y, Dorn GW, 2nd (2013) PINK1-phosphorylated mitofusin 2 is a Parkin receptor for culling damaged mitochondria. Science 340(6131):471-475.
Gong G, et al. (2015) Parkin-mediated mitophagy directs perinatal cardiac metabolic maturation in mice. Science 350(6265):aad2459.
Prudent J, et al. (2015) MAPL SUMOylation of Drp1 stabilizes an ER/mitochondrial platform required for cell death. Mol Cell 59(6):941-955.
Song M, Mihara K, Chen Y, Scorrano L, Dorn GW, 2nd (2015) Mitochondrial fission and fusion factors reciprocally orchestrate mitophagic culling in mouse hearts and cultured fibroblasts. Cell Metab 21(2):273-285.
Raffaello A, et al. (2013) The mitochondrial calcium uniporter is a multimer that can include a dominant-negative pore-forming subunit. EMBO J 32(17):2362-2376.
Luke G, Escuin H, De Felipe P, Ryan M (2010) 2A to the fore - Research, technology and applications. Biotechnol Genet Eng Rev 26:223-260.
Matkovich SJ, Dorn GW, 2nd (2015) Deep sequencing of cardiac microRNA-mRNA interactomes in clinical and experimental cardiomyopathy. Methods Mol Biol 1299:27-49.
Frezza C, Cipolat S, Scorrano L (2007) Organelle isolation: Functional mitochondria from mouse liver, muscle and cultured fibroblasts. Nat Protoc 2(2):287-295.
