Bost, F., Decoux-Poullot, A. G., Tanti, J. F. & Clavel, S. Energy disruptors: rising stars in anticancer therapy Oncogenesis 5, e188 (2016).
Bost, F., Ben Sahra, I., Le Marchand-Brustel, Y. & Tanti, J. F. Metformin and cancer therapy. Curr Opin Oncol 24, 103-108 (2012).
Zakikhani, M., Dowling, R., Fantus, I. G., Sonenberg, N. & Pollak, M. Metformin is an AMP kinase-dependent growth inhibitor for breast cancer cells. Cancer Res. 66, 10269-10273 (2006).
El-Mir, M. Y. et al. Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I. J Biol Chem. 275, 223-228 (2000).
Bridges, H. R., Jones, A. J., Pollak, M. N. & Hirst, J. Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria. Biochem J 462, 475-487 (2014).
Ben Sahra, I. et al. Targeting cancer cell metabolism: The combination of metformin and 2-deoxyglucose induces p53-dependent apoptosis in prostate cancer cells. Cancer Res 70, 2465-2475 (2010).
Bhosale, G., Sharpe, J. A., Sundier, S. Y. & Duchen, M. R. Calcium signaling as a mediator of cell energy demand and a trigger to cell death. Ann N Y Acad Sci 1350, 107-116 (2015).
Kirichok, Y., Krapivinsky, G. & Clapham, D. E. The mitochondrial calcium uniporter is a highly selective ion channel. Nature 427, 360-364 (2004).
Ben Sahra, I. et al. Metformin, Independent of AMPK, Induces mTOR Inhibition and Cell-Cycle Arrest through REDD1. Cancer Res 71, 4366-4372 (2011).
Ben-Sahra, I. et al. Sestrin2 integrates Akt and mTOR signaling to protect cells against energetic stress-induced death. Cell Death Differ 20, 611-619 (2013).
Macmillan, D. & McCarron, J. G. The phospholipase C inhibitor U-73122 inhibits Ca(2+) release from the intracellular sarcoplasmic reticulum Ca(2+) store by inhibiting Ca(2+) pumps in smooth muscle. Br J Pharmacol 160, 1295-1301 (2010).
Marchi, S. & Pinton, P. Alterations of calcium homeostasis in cancer cells. Curr Opin Pharmacol 29, 1-6 (2016).
Ben Sahra, I. et al. The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level. Oncogene 27, 3576-3586 (2008).
Tomic, T. et al. Metformin inhibits melanoma development through autophagy and apoptosis mechanisms. Cell Death Dis 2, e199 (2011).
Deniaud, A. et al. Endoplasmic reticulum stress induces calcium-dependent permeability transition, mitochondrial outer membrane permeabilization and apoptosis. Oncogene 27, 285-299 (2008).
Yang, J. et al. Metformin induces ER stress-dependent apoptosis through miR-708-5p/NNAT pathway in prostate cancer. Oncogenesis 4, e158 (2015).
Sacco, F. et al. Deep Proteomics of Breast Cancer Cells Reveals that Metformin Rewires Signaling Networks Away from a Pro-growth State. Cell Syst 2, 159-171 (2016).
Santo-Domingo, J. et al. The plasma membrane Na+/Ca2+ exchange inhibitor KB-R7943 is also a potent inhibitor of the mitochondrial Ca2+ uniporter. Br J Pharmacol 151, 647-654 (2007).
Garcia-Rivas Gde, J., Carvajal, K., Correa, F. & Zazueta, C. Ru360, a specific mitochondrial calcium uptake inhibitor, improves cardiac post-ischaemic functional recovery in rats in vivo. Br J Pharmacol 149, 829-837 (2006).
Blondin, G. A. & Green, D. E. The mechanism of mitochondrial swelling. Proc Natl Acad Sci USA 58, 612-619 (1967).
Chiche, J. et al. Hypoxic enlarged mitochondria protect cancer cells from apoptotic stimuli. J Cell Physiol 222, 648-657 (2010).
Chen, H., McCaffery, J. M. & Chan, D. C. Mitochondrial fusion protects against neurodegeneration in the cerebellum. Cell 130, 548-562 (2007).
Toyama, E. Q. et al. Metabolism. AMP-activated protein kinase mediates mitochondrial fission in response to energy stress. Science 351, 275-281 (2016).
Schrepfer, E. & Scorrano, L. Mitofusins, from Mitochondria to Metabolism. Mol Cell 61, 683-694 (2016).
Kalender, A. et al. Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner. Cell Metab 11, 390-401 (2010).
Bhamra, G. S. et al. Metformin protects the ischemic heart by the Akt-mediated inhibition of mitochondrial permeability transition pore opening. Basic Res Cardiol 103, 274-284 (2008).
Li, B. et al. Inhibition of complex I regulates the mitochondrial permeability transition through a phosphate-sensitive inhibitory site masked by cyclophilin D. Biochim Biophys Acta 1817, 1628-1634 (2012).
Guigas, B. et al. Metformin inhibits mitochondrial permeability transition and cell death: A pharmacological in vitro study. Biochem J 382, 877-884 (2004).
Kim, H. J., Magrane, J., Starkov, A. A. & Manfredi, G. The mitochondrial calcium regulator cyclophilin D is an essential component of oestrogen-mediated neuroprotection in amyotrophic lateral sclerosis. Brain 135, 2865-2874 (2012).
Halestrap, A. P. What is the mitochondrial permeability transition pore J Mol Cell Cardiol 46, 821-831 (2009).
Cardenas, C. et al. Essential regulation of cell bioenergetics by constitutive InsP3 receptor Ca2+ transfer to mitochondria. Cell 142, 270-283 (2010).
McCormack, J. G., Halestrap, A. P. & Denton, R. M. Role of calcium ions in regulation of mammalian intramitochondrial metabolism. Physiol Rev 70, 391-425 (1990).
El-Mir, M. Y. et al. Neuroprotective role of antidiabetic drug metformin against apoptotic cell death in primary cortical neurons. J Mol Neurosci 34, 77-87 (2008).
Sasaki, H. et al. Metformin prevents progression of heart failure in dogs: role of AMP-activated protein kinase. Circulation 119, 2568-2577 (2009).
Alimova, I. N. et al. Metformin inhibits breast cancer cell growth, colony formation and induces cell cycle arrest in vitro. Cell Cycle 8, 909-915 (2009).
Zhuang, Y. & Miskimins, W. K. Cell cycle arrest in Metformin treated breast cancer cells involves activation of AMPK, downregulation of cyclin D1, and requires p27Kip1 or p21Cip1. J Mol Signal 3, 18 (2008).
Batandier, C., Leverve, X. & Fontaine, E. Opening of the mitochondrial permeability transition pore induces reactive oxygen species production at the level of the respiratory chain complex I. J Biol Chem 279, 17197-17204 (2004).
Plymate, S. R. et al. The effect on the insulin-like growth factor system in human prostate epithelial cells of immortalization and transformation by simian virus-40 T antigen. J Clin Endocrinol Metab 81, 3709-3716 (1996).
Bochaton, T. et al. Inhibition of myocardial reperfusion injury by ischemic postconditioning requires sirtuin 3-mediated deacetylation of cyclophilin D. J Mol Cell Cardiol 84, 61-69 (2015).
Le Brigand, K. et al. An open-access long oligonucleotide microarray resource for analysis of the human and mouse transcriptomes. Nucleic Acids Res 34, e87 (2006).