Abstract :
[en] Secular changes in pubertal timing and particular forms of sexual precocity after migration to new geographical areas whose levels of environment differ from those in the natal country suggest that endocrine-disrupting compounds (EDCs) may be involved. Studies in humans based on measurement of some EDC in relation to pubertal timing are inconclusive for several possible reasons including predominant genetic determinism and effects of complex EDC mixtures. Based on animal models, some possible neuroendocrine mechanisms are discussed as well as the interrelation between the homeostasis of reproduction and energy balance. © 2012, Springer Science+Business Media, LLC.
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