Reference : Genetic architecture of individual variation in recombination rate on the X chromosom...
Scientific journals : Article
Life sciences : Animal production & animal husbandry
Life sciences : Genetics & genetic processes
http://hdl.handle.net/2268/253297
Genetic architecture of individual variation in recombination rate on the X chromosome in cattle.
English
Zhang, Junjie [> >]
Kadri, Naveen Kumar [> >]
Mullaart, Erik [> >]
Spelman, Richard [> >]
Fritz, Sébastien [> >]
Boichard, Didier [> >]
Charlier, Carole mailto [Université de Liège - ULiège > > Medical Genomics-Unit of Animal Genomics >]
Georges, Michel mailto [Université de Liège - ULiège > Dpt. de gestion vétérinaire des Ressources Animales (DRA) > Génomique animale >]
Druet, Tom mailto [Université de Liège - ULiège > > Medical Genomics-Unit of Animal Genomics >]
2020
Heredity
Nature Publishing Group
125
5
304-316
Yes (verified by ORBi)
0018067X
13652540
United Kingdom
[en] Meiotic recombination is an essential biological process that ensures proper chromosome segregation and creates genetic diversity. Individual variation in global recombination rates has been shown to be heritable in several species, and variants significantly associated with this trait have been identified. Recombination on the sex chromosome has often been ignored in these studies although this trait may be particularly interesting as it may correspond to a biological process distinct from that on autosomes. For instance, recombination in males is restricted to the pseudo-autosomal region (PAR). We herein used a large cattle pedigree with more than 100,000 genotyped animals to improve the genetic map of the X chromosome and to study the genetic architecture of individual variation in recombination rate on the sex chromosome (XRR). The length of the genetic map was 46.4 and 121.2 cM in males and females, respectively, but the recombination rate in the PAR was six times higher in males. The heritability of CO counts on the X chromosome was comparable to that of autosomes in males (0.011) but larger than that of autosomes in females (0.024). XRR was highly correlated (0.76) with global recombination rate (GRR) in females, suggesting that both traits might be governed by shared variants. In agreement, a set of eleven previously identified variants associated with GRR had correlated effects on female XRR (0.86). In males, XRR and GRR appeared to be distinct traits, although more accurate CO counts on the PAR would be valuable to confirm these results.
CECI - Consortium des Équipements de Calcul Intensif ; F.R.S.-FNRS - Fonds de la Recherche Scientifique
Researchers
http://hdl.handle.net/2268/253297

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