New β-lactamases: A paradigm for the rapid response of bacterial evolution in the clinical setting

Antimicrobial resistance; Carbapenemases; Evolution; Extended-spectrum β-lactamases; Gram-negative bacteria; AmpC beta lactamases; AmpC beta-lactamases; Enterobacteriaceae; Review; Bacteria; Bacterial Proteins; Carbapenems; Cephalosporins; Evolution, Molecular; Mutation

Abstract :

[en] Production of β-lactamases is one of the most common mechanisms of bacterial resistance to β-lactam antibiotics. In the clinical setting, the introduction of new classes of β-lactams has invariably been followed by the emergence of new β-lactamases capable of degrading them, as a paradigmatic example of rapid bacterial evolution under a rapidly changing selective environment. The scope of this article is to provide an overview on the recent evolution of β-lactamase-mediated resistance among bacterial pathogens. Focus is on the mechanisms of evolution and dissemination of enzymes of greater clinical impact, including the extended-spectrum β-lactamases, the AmpC-type β-lactamases and the carbapenemases, which are currently responsible for emerging resistance to the most recent and powerful β-lactams (the expanded-spectrum cephalosporins and the carbapenems) among major Gram-negative pathogens such as Enterobacteriaceae, Pseudomonas aeruginosa and Acinetobacter. © 2006 Future Medicine Ltd.

Disciplines :

Microbiology

Author, co-author :

Rossolini, G. M.; University of Siena, Department of Molecular Biology, Section of Microbiology, Policlinico Santa Maria alle Scotte, Siena, 53100, Italy

Docquier, Jean-Denis ; Université de Liège - ULiège > Département des sciences de la vie > Centre d'ingénierie des protéines

Language :

English

Title :

New β-lactamases: A paradigm for the rapid response of bacterial evolution in the clinical setting

Publication date :

2006

Journal title :

Future Microbiology

ISSN :

1746-0913

eISSN :

1746-0921

Publisher :

Future Medicine Ltd.

Volume :

Issue :

Pages :

295-308

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 25 November 2020

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