Article (Scientific journals)
Neutrophil extracellular traps infiltrate the lung airway, interstitial, and vascular compartments in severe COVID-19
Radermecker, Coraline; Detrembleur, Nancy; Guiot, Julien et al.
2020In Journal of Experimental Medicine, 217 (12)
Peer Reviewed verified by ORBi
 

Files


Full Text
jem_20201012.pdf
Publisher postprint (5.02 MB)
Request a copy

All documents in ORBi are protected by a user license.

Send to



Details



Abstract :
[en] Infection with SARS-CoV-2 is causing a deadly and pandemic disease called coronavirus disease-19 (COVID-19). While SARS-CoV-2-triggered hyperinflammatory tissue-damaging and immunothrombotic responses are thought to be major causes of respiratory failure and death, how they relate to lung immunopathological changes remains unclear. Neutrophil extracellular traps (NETs) can contribute to inflammation-associated lung damage, thrombosis, and fibrosis. However, whether NETs infiltrate particular compartments in severe COVID-19 lungs remains to be clarified. Here we analyzed postmortem lung specimens from four patients who succumbed to COVID-19 and four patients who died from a COVID-19-unrelated cause. We report the presence of NETs in the lungs of each COVID-19 patient. NETs were found in the airway compartment and neutrophil-rich inflammatory areas of the interstitium, while NET-prone primed neutrophils were present in arteriolar microthrombi. Our results support the hypothesis that NETs may represent drivers of severe pulmonary complications of COVID-19 and suggest that NET-targeting approaches could be considered for the treatment of uncontrolled tissue-damaging and thrombotic responses in COVID-19. © 2020 Radermecker et al. This article is distributed under the terms of an Attribution-Noncommercial-Share Alike-No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution-Noncommercial-Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
Disciplines :
Laboratory medicine & medical technology
Author, co-author :
Radermecker, Coraline ;  Université de Liège - ULiège > I3-Immunophysiology
Detrembleur, Nancy ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Département des sciences biomédicales et précliniques
Guiot, Julien  ;  Université de Liège - ULiège > Département de pharmacie > Département de pharmacie
Cavalier, Etienne  ;  Université de Liège - ULiège > Département de pharmacie > Chimie médicale
HENKET, Monique ;  Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Clinique de l'asthme
D'Emal, Céline ;  Université de Liège - ULiège > Cardiovascular Sciences-Cardiology
Vanwinge, Céline ;  Université de Liège - ULiège > Platform Imaging & Flow cytometry
Cataldo, Didier  ;  Université de Liège - ULiège > Département des sciences cliniques > Labo de biologie des tumeurs et du développement
Oury, Cécile  ;  Université de Liège - ULiège > Cardiovascular Sciences-Cardiology
Delvenne, Philippe ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques
Marichal, Thomas  ;  Université de Liège - ULiège > I3-Immunophysiology
Language :
English
Title :
Neutrophil extracellular traps infiltrate the lung airway, interstitial, and vascular compartments in severe COVID-19
Publication date :
November 2020
Journal title :
Journal of Experimental Medicine
ISSN :
0022-1007
eISSN :
1540-9538
Publisher :
Rockefeller University Press
Volume :
217
Issue :
12
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
CER - Conseil Européen de la Recherche [BE]
Fondation Acteria (Agir sur la Recherche européenne en Immunologie et en Allergologie) [CH]
Fondation Léon Fredericq [BE]
Available on ORBi :
since 24 November 2020

Statistics


Number of views
134 (23 by ULiège)
Number of downloads
6 (6 by ULiège)

Scopus citations®
 
252
Scopus citations®
without self-citations
244
OpenCitations
 
227

Bibliography


Similar publications



Contact ORBi