Bovine herpesvirus 1 (BHV1); Danish test system; ELISA; gB; gE
Abstract :
[en] Animals persistently infected with BVDV are important in the epizootiology of the Bovine Viral Diarrhea (BVD) because they are a permanent source of contamination within a herd. These animals produce large quantities of virus and have, therefore, been proposed as responsible for generating antigenic variability. However, limited studies have failed to detect antigenic or genetic changes in viruses isolated at different time from persistently infected animals. One hypothesis to account for this stability is that the immunotolerance is accompanied by a selection against antigenic change. The presence of an immunotolerant persistently infected (IPI) animal in a herd would in turn lead to herd specific strains. To verify this hypothesis, we compared 17 BVDV strains isolated from IPI animals from 3 herds of Eastern Belgium. The comparison was based on the sequence of a 389 bp fragment of E2--a gene encoding for a highly variable glycoprotein. Sequences were strongly conserved within herds but were quite different between herds, indicating that BVDV herd-specific strains do exist and are associated with the presence of IPI animals.
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Hamers, Claude ; Université de Liège - ULiège > Département des maladies infectieuses et parasitaires (DMI) > Immunologie et vaccinologie
Lecomte, Corine ; Université de Liège - ULiège > Département des maladies infectieuses et parasitaires (DMI) > Immunologie et vaccinologie
Kulcsar, G.; State Control Institute for Veterinary Biologicals > Drugs and Feeds
Lambot, Michel ; Université de Liège - ULiège > Département des maladies infectieuses et parasitaires (DMI) > Immunologie et vaccinologie
Pastoret, Paul-Pierre ; Université de Liège - ULiège > Département des maladies infectieuses et parasitaires (DMI) > Immunologie et vaccinologie
Language :
English
Title :
Persistently Infected Cattle Stabilise Bovine Viral Diarrhea Virus Leading to Herd Specific Strains
Ackermann, M., Peterhans, E., Wyler, R., DNA of bovine herpesvirus type 1 in the trigeminal ganglia of latently infected calves (1982) Am. J. Vet. Res., 43, pp. 36-40
Ackermann, M., Wyler, R., The DNA of an IPV strain of Bovid herpesvirus 1 in sacral ganglia during latency after intravaginal infection (1984) Vet. Microbiol., 9, pp. 53-63
Ackermann, M., Belak, S., Bitsch, V., Edwards, S., Moussa, A., Rockborn, G., Thiry, E., Round table on infectious bovine rhinotracheitis/infectious pustular vulvovaginitis virus infection diagnosis and control (1990) Vet. Microbiol., 23, pp. 361-363
Bitsch, V., Infectious bovine rhinotracheitis virus infection in bulls, with special reference to preputial infection (1973) Appl. Microbiol., 26, pp. 337-343
Ellens, D.J., Gielkens, A.L.J., A simple method for the purification of 5-aminosalicylic acid. Application of the product as substrate in enzyme-linked immunosorbent assay (ELISA) (1980) J. Immun. Meth., 37, pp. 325-332
Engels, M., Ackermann, M., Pathogenesis of ruminant herpesvirus infections (1996) Vet. Microbiol., 53, pp. 3-15
Frankena, K., Noordhuizen, J.P., Willeberg, P., Van Voorthuysen, P.F., Goelema, J.O., Episcope: Computer programs in veterinary epidemiology (1990) Vet. Rec., 126, pp. 573-576
Guérin, C., Harley, T., Guérin, B., Thibier, M., Distribution of BHV1 in fractions of semen from a naturally infected bull (1993) Theriogenology, 40, pp. 997-1002
Hage, J.J., Schukken, Y.H., Barkema, H.W., Benedictus, G., Rijsewijk, F.A.M., Wentink, G.H., Population dynamics of BHV1 infection in a dairy herd (1996) Vet. Microbiol., 53, pp. 169-180
Kaashoek, M.J., Moerman, A., Madic, J., Rijsewijk, F.A.M., Quak, J., Gielkens, A.L.J., Van Oirschot, J.T., A conventionally attenuated glycoprotein E-negative strain of bovine herpesvirus 1 is an efficacious and safe vaccine (1994) Vaccine, 12, pp. 439-444
Kaashoek, M.J., Moerman, A., Madic, J., Weerdmeester, K., Maris-Veldhuis, M.A., Rijsewijk, F.A.M., Van Oirschot, J.T., An inactivated vaccine based on a glycoprotein E-negative strain of bovine herpesvirus 1 induces protective immunity and allows serological differentiation (1995) Vaccine, 13, pp. 342-346
Kaashoek, M.J., Rijsewijk, F.A.M., Maris-Veldhuis, M.A., Van Oirschot, J.T., Non essential glycoproteins gC, gG, gI and gE are expressed in all of 223 isolates of bovine herpesvirus 1 (1995) In: Marker Vaccines Against Bovine Herpesvirus 1 Infections, , Kaashoek M.J., Ph.D Thesis, Utrecht University
Kaashoek, M.J., Rijsewijk, F.A.M., Van Oirschot, J.T., Persistence of antibodies against bovine herpesvirus 1 and virus reactivation two to three years after infection (1996) Vet. Microbiol., 53, pp. 103-110
Kramps, J.A., Quak, J., Weerdmeester, K., Van Oirschot, J.T., Comparative study on sixteen enzyme-linked immunosorbent assays for the detection of antibodies to bovine herpesvirus 1 in cattle (1993) Vet. Microbiol., 35, pp. 11-21
Kramps, J.A., Magdalena, J., Quak, J., Weerdmeester, K., Kaashoek, M.J., Maris-Veldhuis, M.A., Rijsewijk, F.A.M., Van Oirschot, J.T., A simple, specific, and highly sensitive blocking enzyme-linked immunosorbent assay for detection of antibodies to bovine herpesvirus 1 (1994) J. Clin. Microbiol., 32, pp. 2175-2181
Martin, S.W., Meek, A.H., Willeberg, P., (1988) Veterinary Epidemiology, Principles and Methods, pp. 69-71. , Iowa State University Press, Ames, IO, pp
Msolla, P.M., Allan, E.M., Selman, I.E., Wiseman, A., Reactivation and shedding of bovine herpesvirus 1 following Dictiocaulus viviparus infection (1983) J. Comp. Pathol., 93, pp. 271-274
Pastoret, P.-P., Aguilar-Setien, A., Burtonboy, G., Schoenaers, F., Measurement of the re-excretion of infectious bovine rhinotracheitis virus after dexamethasone injection (1978) Ann. Med. Vet., 122, pp. 449-456
Spear, P.G., Entry of alphaherpesviruses into cells (1993) Semin. Virol., 4, pp. 167-180
Thiry, E., Saliki, J., Bublot, M., Pastoret, P.-P., Reactivation of bovine rhinotracheitis virus by transport (1987) Comp. Immunol. Microbiol. Infect. Dis., 10, pp. 59-63
Van Bekkum, J.G., Straver, P.J., The recent evolution of IBR in the Netherlands (1975) Bulletin de L'office International des Epizooties LXIIIe Session Générale, Rapport No., 114
Van Engelenburg, F.A.C., Kaashoek, M.J., Rijsewijk, F.A.M., Van Den Burg, L., Moerman, A., Gielkens, A.L.J., Van Oirschot, J.T., A glycoprotein E deletion mutant of bovine herpesvirus 1 is avirulent in calves (1994) J. Gen. Virol., 75, pp. 2311-2318
Van Oirschot, J.T., Straver, P.J., Van Lieshout, J.A.H., Quak, J., Westenbrink, F., Van Exsel, A.C.A., A subclinical infection of bulls with bovine herpesvirus type 1 at an artificial insemination centre (1993) Vet. Rec., 132, pp. 32-35
Van Oirschot, J.T., Kaashoek, M.J., Maris-Veldhuis, M.A., Weerdmeester, K., Rijsewijk, F.A.M., (1997) An Enzyme Linked Immunosorbent Assay to Detect Antibodies Against Glycoprotein Ge of Bovine Herpesvirus 1 Allows Differentiation between Infected and Vaccinated Cattle, , (Submitted)
Van Wuijckhuise, L., Bosch, J., Franken, P., Hage, J.J., Verhoeff, J., Zimmer, G., The prevalence of Infectious Bovine Rhinotracheitis in the Netherlands (1993) Proceedings of the Dutch Society for Veterinary Epidemiology and Economics, pp. 7-15. , Boxtel, pp
