Article (Scientific journals)
Occurrence of conjugative IncF-type plasmids harboring the bla CTX-M-15 gene in Enterobacteriaceae isolates from newborns in Tunisia
Lahlaoui, H.; De Luca, F.; Maradel, S. et al.
2015In Pediatric Research, 77 (1), p. 107-110
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Keywords :
Article; Citrobacter freundii; Enterobacter aerogenes; Enterobacter cloacae; Escherichia coli; Klebsiella oxytoca; Klebsiella pneumoniae; Serratia marcescens; Tunisia; Enterobacteriaceae; Escherichia coli infection; Klebsiella infection; Academic Medical Centers; Cefotaxime; Drug Resistance, Bacterial; Escherichia coli Infections; Evolution, Molecular; Genetic Variation; Humans; Infant, Newborn; Klebsiella Infections; Microbial Sensitivity Tests; Molecular Epidemiology; Plasmids
Abstract :
[en] Background:CTX-M-15 is the dominant type of extended-spectrum β-lactamase in clinical isolates. This enzyme constitutes the most widespread enzymes in Tunisia. In this study, we were interested to understand the causes of the evolutionary success of CTX-M-15 in a Tunisian university hospital.Methods:A total of of 72 cefotaxime-resistant Enterobacteriaceae were isolated from newborn patients at the hospital Taher sfar Mahdia in Tunisia and characterized their genetic support by means of molecular techniques.Results:Isolates were clustered into various clonal groups, although most isolates belonged to sequence types ST39 (Klebsiella pneumoniae) and ST131 (Escherichia coli). F replicons (FIA, FIB, and FII) were the most frequently detected replicon types in our collection (91.66%).Conclusion:This is the first report of QnrB-and CTX-M-15-encoding large IncF-type conjugative plasmids in Tunisia. © 2015 International Pediatric Research Foundation, Inc.
Disciplines :
Microbiology
Author, co-author :
Lahlaoui, H.;  Laboratory of Microbiology, Military Hospital of Tunis, Monfleury, Tunisia
De Luca, F.;  Department of Medical Biotechnology, University of Siena, Siena, Italy
Maradel, S.;  Department of Medical Biotechnology, University of Siena, Siena, Italy
Ben-Haj-Khalifa, A.;  Laboratory of Microbiology, Hospital Tahar Sfar, Mahdia, Tunisia
Ben Hamouda, H.;  Laboratory of Microbiology, Hospital Tahar Sfar, Mahdia, Tunisia
Kheder, M.;  Laboratory of Microbiology, Hospital Tahar Sfar, Mahdia, Tunisia
Ben Moussa, M.;  Laboratory of Microbiology, Military Hospital of Tunis, Monfleury, Tunisia
Rossollini, G.M.
Docquier, Jean-Denis ;  Université de Liège - ULiège > Département des sciences de la vie > Centre d'ingénierie des protéines
Language :
English
Title :
Occurrence of conjugative IncF-type plasmids harboring the bla CTX-M-15 gene in Enterobacteriaceae isolates from newborns in Tunisia
Publication date :
2015
Journal title :
Pediatric Research
ISSN :
0031-3998
eISSN :
1530-0447
Publisher :
Nature Publishing Group
Volume :
77
Issue :
1
Pages :
107-110
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 19 November 2020

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