Article (Scientific journals)
Antioxidant and anti-cancer activities of proanthocyanidins-rich extracts from three varieties of sorghum (Sorghum bicolor) bran
Zhu, Yingying; Shi, Z.; Yao, Y. et al.
2017In Food and Agricultural Immunology, 28 (6), p. 1530-1543
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Keywords :
HepG2 cancer cells; Sorghum proanthocyanidins
Abstract :
[en] Hepatocellular carcinoma is the fifth frequently diagnosed cancer in humans. Proanthocyanidins was reported to be an excellent dietary botanical supplement for its antioxidant and anticancer effects. In this study, proanthocyanidins-rich extracts (PREs) were prepared from three varieties (Jinza No. 12, Jinza No. 15 and Jinza No. 18) of sorghum bran. Their proanthocyanidins profiles were characterized. Antioxidant assay showed that PRE samples from Jinza No. 12 and Jinza No. 15 had significant higher (p <.05) hydroxyl radical, 1-diphenyl-2-picrylhydrazyl radical and oxygen radical-scavenging capacities compared to PRE from Jinza No. 18. Stronger anti-proliferation and inhibition of cell migration (p <.05) in HepG2 cancer cells were also demonstrated among the PRE samples from Jinza No. 12 and Jinza No. 15. Intracellular signaling array analysis demonstrated an up-regulated level of phosphorylated 5’AMP-activated protein kinase α and down-regulated levels of phosphorylated extracellular signal-regulated kinase 1/2 (ERK1/2) and p38. © 2017 Informa UK Limited, trading as Taylor & Francis Group.
Disciplines :
Agriculture & agronomy
Author, co-author :
Zhu, Yingying ;  Université de Liège - ULiège > Doct. sc. agro. & ingé. biol. (Paysage)
Shi, Z.;  Institute of Crop Science, Chinese Academy of Agricultural Sciences (CAAS), Haidian, China, Animal Science Unit, Gembloux Agro-Bio Tech, University of Liège, Gembloux, Belgium
Yao, Y.;  Institute of Crop Science, Chinese Academy of Agricultural Sciences (CAAS), Haidian, China
Hao, Y.;  Institute of Crop Science, Chinese Academy of Agricultural Sciences (CAAS), Haidian, China
Ren, G.;  Institute of Crop Science, Chinese Academy of Agricultural Sciences (CAAS), Haidian, China
Language :
English
Title :
Antioxidant and anti-cancer activities of proanthocyanidins-rich extracts from three varieties of sorghum (Sorghum bicolor) bran
Publication date :
2017
Journal title :
Food and Agricultural Immunology
ISSN :
0954-0105
eISSN :
1465-3443
Publisher :
Taylor & Francis, United Kingdom
Volume :
28
Issue :
6
Pages :
1530-1543
Peer reviewed :
Peer Reviewed verified by ORBi
Name of the research project :
Hong Kong, Macao, and Taiwan Science and Technology Cooperation Program of China (2013DFH30050); Agricultural Science and Technology Program for Innovation Team on Identification and excavation of Elite Crop Germplasm, CAAS
Funders :
ULiège. GxABT - Liège Université. Gembloux Agro-Bio Tech [BE]
CAAS - Chinese Academy of Agricultural Sciences [CN]
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