Article (Scientific journals)
Methyl-beta-cyclodextrin concurs with interleukin (IL)-4, IL-13 and IL-25 to induce alterations reminiscent of atopic dermatitis in reconstructed human epidermis.
De Vuyst, Evelyne; Giltaire, Severine; Lambert de Rouvroit, Catherine et al.
2018In Experimental Dermatology, 27 (4), p. 435-437
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Keywords :
atopic dermatitis; epidermal barrier and methyl-beta-cyclodextrin; interleukins; reconstructed human epidermis
Abstract :
[en] Reconstructed human epidermis (RHE) mimic normal human in vivo epidermis in terms of histology, distribution of differentiation markers and barrier functionality. A typical transcriptional profile and the activation of signalling pathways reminiscent of atopic dermatitis (AD) lesional skin can be obtained in RHE upon incubation with methyl-β-cyclodextrin (MβCD), a molecule that extracts cholesterol from plasma membranes, thereby disrupting lipid microdomains. However, barrier function and morphology remain unaltered in those conditions, requiring further refinement of the model.
Disciplines :
Dermatology
Author, co-author :
De Vuyst, Evelyne
Giltaire, Severine
Lambert de Rouvroit, Catherine
Malaisse, Jeremy
Mound, Abdallah
Bourtembourg, Maureen
Poumay, Yves
NIKKELS, Arjen ;  Centre Hospitalier Universitaire de Liège - CHU > Autres Services Médicaux > Service de dermatologie
Chretien, Aline
Salmon, Michel
Language :
English
Title :
Methyl-beta-cyclodextrin concurs with interleukin (IL)-4, IL-13 and IL-25 to induce alterations reminiscent of atopic dermatitis in reconstructed human epidermis.
Publication date :
2018
Journal title :
Experimental Dermatology
ISSN :
0906-6705
eISSN :
1600-0625
Publisher :
Blackwell, Oxford, United Kingdom
Volume :
27
Issue :
4
Pages :
435-437
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 21 October 2020

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