Vitamin D Status and its correlation with Parathyroid Hormone level among population in Riyadh, Saudi Arabia

[en] This study aimed to assess the relationship between vitamin D [25(OH)D] status and parathyroid hormone (PTH) in Saudi adults to determine the optimum 25(OH)D cut-off in the Saudi adult population. A total of 1093 apparently healthy Saudi subjects (720 women and 373 men) aged 50.7 ± 13.9 years were included in this cross-sectional study. Serum 25(OH)D, PTH, calcium and albumin levels were determined. The over-all prevalence of 25(OH)D deficiency (<50 nmol/) was 42.5% (N = 464). The overall prevalence of severe 25(OH)D deficiency (<25 nmol/L) was 24% (N = 262). In all subjects, there is a significant inverse relationship between serum PTH and 25(OH)D (r = − 0.40; p < 0.0001), but no distinct plateau for serum PTH with rising of serum 25(OH)D levels were observed. Despite the lack of threshold, the rising trend in serum 25(OH)D levels had an equivalent gradual decline in PTH levels in both males and females (p < 0.001). In conclusion, the lack of optimum 25(OH)D cut-off in the present study may suggest a lower threshold for the Saudi population and the current definitions for vitamin D status overestimate the true prevalence of vitamin D deficiency in Saudi Arabia. © 2020 The Author(s)

Disciplines :

General & internal medicine

Author, co-author :

Al-Daghri, N. M.; Chair for Biomarkers of Chronic Diseases, Biochemistry Department, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia

Yakout, S.; Chair for Biomarkers of Chronic Diseases, Biochemistry Department, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia

Aljohani, N.; Specialized Diabetes and Endocrine Center, King Fahad Medical City, Faculty of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh, 11525, Saudi Arabia

Al-Saleh, Y.; Chair for Biomarkers of Chronic Diseases, Biochemistry Department, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia, College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia, King Abdullah International Medical Research Center, Riyadh, 11426, Saudi Arabia, Department of Medicine, King Abdulaziz Medical City, Riyadh, Saudi Arabia

Al-Attas, O. S.; Chair for Biomarkers of Chronic Diseases, Biochemistry Department, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia

Reginster, Jean-Yves ; Université de Liège - ULiège > Département des sciences de la santé publique > Santé publique, Epidémiologie et Economie de la santé

Al-Disi, D.; Department of Community Health Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, 11451, Saudi Arabia

Alokail, M. S.; Chair for Biomarkers of Chronic Diseases, Biochemistry Department, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia

Language :

English

Title :

Vitamin D Status and its correlation with Parathyroid Hormone level among population in Riyadh, Saudi Arabia

Publication date :

2020

Journal title :

Journal of King Saud University - Science

ISSN :

1018-3647

Publisher :

Elsevier B.V.

Volume :

Issue :

Pages :

2016-2019

Name of the research project :

International Scientific Partnership Program ISPP #0111

Funders :

KSU - King Saud University [SA]

Available on ORBi :

since 21 October 2020

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