Article (Scientific journals)
Prevalence of Histological Characteristics of Breast Cancer in Rwanda in Relation to Age and Tumor Stages
Uyisenga, Jeanne; Butera, Yvan; Debit, Ahmed et al.
2020In Hormones and Cancer
Peer reviewed
 

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Keywords :
Breast cancer; Molecular subtypes; Rwanda; Sub-Saharan Africa
Abstract :
[en] Breast cancer is a complex disease, and it is the most common cause of morbidity and mortality among women worldwide. In Sub-Saharan Africa, the clinical characteristics and tumor profiles of breast cancer are still unknown. In the present study we aimed to determine breast tumor profiles of the Rwandan patients in relation to age and tumor stages. We compare our findings to related results from other sub-Saharan Africa studies. Data on age at diagnosis, tumor stage, and hormonal profiles of 138 patients diagnosed between January 2015 and December 2018 were retrospectively retrieved from electronic medical records at three referral hospitals in Rwanda. We compared our results to related findings reported in other Sub-Saharan African countries. All statistical analyses were done using SPSS Inc., Chicago, IL, USA, version 20 and R software languages. The mean age at diagnosis was 49.7 years (SD = 13) and ranged from 17 to 86 years. The majority of patients (57.2%) were diagnosed before 50 years of age compared with 42.8% aged > 50 years. Tumor stage III was the commonest accounting for 62% followed by stage II with 24.8%. The distribution of breast tumor subtypes was ER−, PR−, HER2−: 37.7%; ER+, PR+, HER2−: 31.2%; ER−, PR−, HER2+: 14.5%; ER+, PR+, HER2+: 5.1%; and other subtypes represented 11.6%. There was no statistically significant difference in age and tumor stages between the molecular subtypes. Our findings revealed the predominance of hormonal negative tumors among Rwandan patients with breast cancer. Triple negative was found to be the most common breast tumor subtype regardless of age and tumor stage. Larger prospective studies could examine genetics and environmental factors that may play a role in the differences of tumor characteristics in Sub-Saharan populations. © 2020, Springer Science+Business Media, LLC, part of Springer Nature.
Disciplines :
Oncology
Author, co-author :
Uyisenga, Jeanne ;  Université de Liège - ULiège > GIGA
Butera, Yvan  ;  Université de Liège - ULiège > GIGA
Debit, Ahmed ;  Université de Liège - ULiège > GIGA
JOSSE, Claire  ;  Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Service d'oncologie médicale
Ainhoa, C. C.;  Rwanda Cancer Centre, Rwanda Military Hospital, Kanombe, Kigali, 4062, Rwanda
Karinganire, E.;  Rwanda Cancer Centre, Rwanda Military Hospital, Kanombe, Kigali, 4062, Rwanda
Cyuzuzo, A. P.;  College of Science and Technology, University of Rwanda, Kigali, 4285, Rwanda
Umurungi, N.;  College of Science and Technology, University of Rwanda, Kigali, 4285, Rwanda
Kalinijabo, Y.;  College of Science and Technology, University of Rwanda, Kigali, 4285, Rwanda
Uwimana, S.;  Kigali University Teaching Hospital, PO Box 655, Kigali, Rwanda
Mutesa, L.;  Center for Human Genetics, College of Medicine and Health Sciences, University of Rwanda, Kigali, 4285, Rwanda
Bours, Vincent ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Génétique humaine
Language :
English
Title :
Prevalence of Histological Characteristics of Breast Cancer in Rwanda in Relation to Age and Tumor Stages
Publication date :
2020
Journal title :
Hormones and Cancer
ISSN :
1868-8497
eISSN :
1868-8500
Publisher :
Springer
Peer reviewed :
Peer reviewed
Funders :
ARES - Académie de Recherche et d'Enseignement Supérieur [BE]
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since 03 September 2020

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