Article (Scientific journals)
Humoral and cellular immune response to a Microsporum canis recombinant keratinolytic metalloprotease (r-MEP3) in experimentally infected guinea pigs
Brouta, Frédéric; Descamps, Frédéric; Vermout, Sandy et al.
2003In Medical Mycology, 41 (6), p. 495-501
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Keywords :
immune response; keratinase; metalloprotease; Microsporum canis
Abstract :
[en] In order to better understand the host-fungus relationship in Microsporum canis dermatophytosis and to identify major fungal antigens, the immune response to a crude exoantigen preparation and to a purified recombinant keratinolytic metalloprotease (r-MEP3) was evaluated in guinea pigs experimentally infected with M. canis. Humoral and cellular immune responses were assessed from day 0 to day 57 post-infection (PI), the former by enzyme-linked immunosorbent assay (ELISA) and the latter via a lymphocyte proliferation assay. Infected guinea pigs developed humoral and cellular responses to both M. canis exoantigen and r-MEP3, while no specific immune response to these antigens was observed in control animals. This is the first report on the development of both humoral and cell-mediated immune responses to a purified keratinase in M. canis dermatophytosis.
Disciplines :
Veterinary medicine & animal health
Phytobiology (plant sciences, forestry, mycology...)
Author, co-author :
Brouta, Frédéric
Descamps, Frédéric
Vermout, Sandy
Monod, Michel
Losson, Bertrand ;  Université de Liège - ULiège > Département des maladies infectieuses et parasitaires > Parasitologie et pathologie des maladies parasitaires
Mignon, Bernard ;  Université de Liège - ULiège > Département des maladies infectieuses et parasitaires > Parasitologie et pathologie des maladies parasitaires
Language :
English
Title :
Humoral and cellular immune response to a Microsporum canis recombinant keratinolytic metalloprotease (r-MEP3) in experimentally infected guinea pigs
Publication date :
December 2003
Journal title :
Medical Mycology
ISSN :
1369-3786
eISSN :
1460-2709
Publisher :
Taylor & Francis Ltd, Abingdon, United Kingdom
Volume :
41
Issue :
6
Pages :
495-501
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 04 October 2009

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