Article (Scientific journals)
IGF2 antisense transcript expression in porcine postnatal muscle is affected by a quantitative trait nucleotide in intron 3.
Braunschweig, Martin H.; Van Laere, Anne-Sophie; Buys, Nadine et al.
2004In Genomics, 84 (6), p. 1021-9
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Keywords :
Animals; Fetus/metabolism; Gene Expression Regulation, Developmental; Genetic Variation; Genomic Imprinting; Genotype; Insulin-Like Growth Factor II/genetics/metabolism; Introns/genetics; Liver/growth & development/metabolism; Molecular Sequence Data; Muscle Development/genetics; Muscles/anatomy & histology/metabolism; Phenotype; Polymorphism, Genetic; Quantitative Trait Loci; RNA, Antisense/genetics/metabolism; Swine/anatomy & histology/genetics/growth & development
Abstract :
[en] A paternally expressed quantitative trait locus (QTL) for muscle mass was mapped to the insulin-like growth factor II (IGF2) locus at the distal end of pig chromosome 2p. It was recently demonstrated that a G to A transition at position intron 3-nt 3072 is the quantitative trait nucleotide (QTN) underlying this QTL. In this study we report for the first time the existence of imprinted porcine IGF2 antisense transcripts (IGF2-AS) and demonstrate that their expression in postnatal muscle is also affected by the QTN. A coregulated expression of IGF2 and IGF2-AS RNAs in muscle and liver with decreasing transcription from fetal to adult age was demonstrated. Further, the significant difference found in expression of IGF2-AS in postnatal muscle between individuals with different QTL genotypes and the lack of significant differences in fetal muscle and liver reflect completely what has been found for IGF2 sense transcripts.
Disciplines :
Genetics & genetic processes
Author, co-author :
Braunschweig, Martin H.
Van Laere, Anne-Sophie  ;  Université de Liège > Département de morphologie et pathologie (DMP) > Pathologie spéciale et autopsies
Buys, Nadine
Andersson, Leif
Andersson, Goran
Language :
English
Title :
IGF2 antisense transcript expression in porcine postnatal muscle is affected by a quantitative trait nucleotide in intron 3.
Publication date :
2004
Journal title :
Genomics
ISSN :
0888-7543
eISSN :
1089-8646
Publisher :
Elsevier, Atlanta, Georgia
Volume :
84
Issue :
6
Pages :
1021-9
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 28 July 2020

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