Deoxycholate amphotericin B and amphotericin B lipid complex exert additive antifungal activity in combination with pulmonary alveolar macrophages against Fusarium solani.

Roilides, Emmanuel; Lyman, Caron A.; Armstrong, Derek; STERGIOPOULOU, Theodouli; Petraitiene, Ruta; Walsh, Thomas J.

doi:10.1111/j.1439-0507.2006.01202.x

Article (Scientific journals)

Deoxycholate amphotericin B and amphotericin B lipid complex exert additive antifungal activity in combination with pulmonary alveolar macrophages against Fusarium solani.

Roilides, Emmanuel; Lyman, Caron A.; Armstrong, Derek et al.

2006 • In Mycoses, 49 (2), p. 109-13

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/249626

DOI
10.1111/j.1439-0507.2006.01202.x

PubMed
16466443

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Keywords :

Amphotericin B/pharmacology; Animals; Antifungal Agents/pharmacology; Cells, Cultured; Deoxycholic Acid/pharmacology; Drug Combinations; Female; Fusarium/drug effects/immunology; Humans; Macrophages, Alveolar/drug effects/immunology; Phosphatidylcholines/pharmacology; Phosphatidylglycerols/pharmacology; Rabbits

Abstract :

[en] Fusarium spp. have emerged as important causes of invasive fungal infections in immunocompromised patients. Rabbit pulmonary alveolar macrophages (PAMs) exhibited fungicidal activity against conidia of Fusarium solani and achieved a time-dependent increase in killing. Neither deoxycholate amphotericin B (DAMB) nor amphotericin B lipid complex (ABLC) exerted a suppressive effect on PAMs by decreasing their conidiocidal activity against F. solani. On the contrary, at a concentration of 0.125 microg ml(-1), ABLC and, to a lesser degree, DAMB additively augmented the fungicidal activity of pulmonary alveolar macrophages against conidia of Fusarium solani.

Disciplines :

Immunology & infectious disease

Author, co-author :

Roilides, Emmanuel

Lyman, Caron A.

Armstrong, Derek

STERGIOPOULOU, Theodouli ; Centre Hospitalier Universitaire de Liège - CHU > Pédiatrie

Petraitiene, Ruta

Walsh, Thomas J.

Language :

English

Title :

Deoxycholate amphotericin B and amphotericin B lipid complex exert additive antifungal activity in combination with pulmonary alveolar macrophages against Fusarium solani.

Publication date :

2006

Journal title :

Mycoses

ISSN :

0933-7407

eISSN :

1439-0507

Publisher :

Blackwell, Oxford, United Kingdom

Volume :

Issue :

Pages :

109-13

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 13 July 2020

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