Article (Scientific journals)
Interleukin 10 suppresses phagocytic and antihyphal activities of human neutrophils.
Roilides, E.; Katsifa, H.; Tsaparidou, S. et al.
2000In Cytokine, 12 (4), p. 379-87
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Keywords :
Adult; Candida albicans/immunology/pathogenicity; Cell Nucleus/drug effects; Cytoplasm/drug effects; Humans; Immunosuppressive Agents/immunology/pharmacology; Interleukin-10/immunology/pharmacology; Neutrophils/drug effects/immunology/microbiology; Phagocytosis/drug effects/immunology; Recombinant Proteins/immunology/pharmacology; Staphylococcus aureus/immunology/pathogenicity; Superoxides/immunology
Abstract :
[en] We investigated the effects of human interleukin 10 (IL-10) on the antibacterial and antifungal activities of human neutrophils (PMNs) against Staphylococcus aureus and Candida albicans. Incubation of PMNs from healthy volunteers with 20-100 ng/ml of IL-10 at 37 degrees C for 1 h suppressed phagocytosis of serum-opsonized S. aureus (P=0.02) and blastoconidia of C. albicans (P<0.01). In contrast, 2-100 ng/ml of IL-10 had no effect on superoxide anion production upon stimulation with phorbol myristate acetate, N-formylmethionyl leucyl phenylalanine, C. albicans blastoconidia or pseudohyphae; neither did it significantly affect conidiocidal or bactericidal activities of PMNs. However, 20-100 ng/ml of IL-10 significantly decreased PMN-induced damage of C. albicans pseudohyphae (P=0.008). The suppression of phagocytic activity of PMNs against S. aureus and blastoconidia of C. albicans as well as the impairment of PMN-induced hyphal damage may have important implications for understanding the immunosuppressive profile of IL-10 in clinical usage.
Disciplines :
Immunology & infectious disease
Author, co-author :
Roilides, E.
Katsifa, H.
Tsaparidou, S.
STERGIOPOULOU, Theodouli ;  Centre Hospitalier Universitaire de Liège - CHU > Pédiatrie
Panteliadis, C.
Walsh, T. J.
Language :
English
Title :
Interleukin 10 suppresses phagocytic and antihyphal activities of human neutrophils.
Publication date :
2000
Journal title :
Cytokine
ISSN :
1043-4666
eISSN :
1096-0023
Publisher :
Elsevier, Atlanta, United States - California
Volume :
12
Issue :
4
Pages :
379-87
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 13 July 2020

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