Interleukin 10 suppresses phagocytic and antihyphal activities of human neutrophils.

Adult; Candida albicans/immunology/pathogenicity; Cell Nucleus/drug effects; Cytoplasm/drug effects; Humans; Immunosuppressive Agents/immunology/pharmacology; Interleukin-10/immunology/pharmacology; Neutrophils/drug effects/immunology/microbiology; Phagocytosis/drug effects/immunology; Recombinant Proteins/immunology/pharmacology; Staphylococcus aureus/immunology/pathogenicity; Superoxides/immunology

Abstract :

[en] We investigated the effects of human interleukin 10 (IL-10) on the antibacterial and antifungal activities of human neutrophils (PMNs) against Staphylococcus aureus and Candida albicans. Incubation of PMNs from healthy volunteers with 20-100 ng/ml of IL-10 at 37 degrees C for 1 h suppressed phagocytosis of serum-opsonized S. aureus (P=0.02) and blastoconidia of C. albicans (P<0.01). In contrast, 2-100 ng/ml of IL-10 had no effect on superoxide anion production upon stimulation with phorbol myristate acetate, N-formylmethionyl leucyl phenylalanine, C. albicans blastoconidia or pseudohyphae; neither did it significantly affect conidiocidal or bactericidal activities of PMNs. However, 20-100 ng/ml of IL-10 significantly decreased PMN-induced damage of C. albicans pseudohyphae (P=0.008). The suppression of phagocytic activity of PMNs against S. aureus and blastoconidia of C. albicans as well as the impairment of PMN-induced hyphal damage may have important implications for understanding the immunosuppressive profile of IL-10 in clinical usage.

Disciplines :

Immunology & infectious disease

Author, co-author :

Roilides, E.

Katsifa, H.

Tsaparidou, S.

STERGIOPOULOU, Theodouli ; Centre Hospitalier Universitaire de Liège - CHU > Pédiatrie

Panteliadis, C.

Walsh, T. J.

Language :

English

Title :

Interleukin 10 suppresses phagocytic and antihyphal activities of human neutrophils.

Publication date :

2000

Journal title :

Cytokine

ISSN :

1043-4666

eISSN :

1096-0023

Publisher :

Elsevier, Atlanta, United States - California

Volume :

Issue :

Pages :

379-87

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 13 July 2020

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