Reference : Comparison of Sublingual and Oral Prazepam in Normal Subjects. I. Clinical Data
Scientific journals : Article
Human health sciences : Psychiatry
Human health sciences : Neurology
http://hdl.handle.net/2268/249065
Comparison of Sublingual and Oral Prazepam in Normal Subjects. I. Clinical Data
English
Ansseau, Marc mailto [Université de Liège - ULiège > Département des sciences cliniques > Psychiatrie et psychologie médicale]
von Frenckell, Rémy [Université de Liège - ULiège > > > > Psychiatrie et psychologie médicale > >]
Jacqmin, Philippe [Université Catholique de Louvain - UCL > > > > > >]
1987
Neuropsychobiology
Karger
18
2
77-82
Yes (verified by ORBi)
International
0302-282X
1423-0224
Basel
Switzerland
[en] Benzodiazepines ; Prazepam ; Sublingual prazepam ; Vigilance ; Visual analogue scales
[en] Five normal volunteers received at a 2-week interval a single dose of sublingual or oral prazepam in double-blind and cross-over conditions. All subjects completed a battery of 15 visual analogue scales before drug intake and 7.5, 15, 22.5, 30, 45, 60, 90 min, 2, 3, 5, 6, 7, 8, 9, 10 and 24 h following intake whereas a computerized assessment of vigilance (reaction time) was performed before intake, 15, 30, 60 min, 2, 3, 6, 8, 10 h following intake. Subjects rated themselves significantly more feeble, clumsy, lethargic, and incompetent following sublingual as compared to oral prazepam while a trend in the same direction was noted for the adjectives muzzy and mentally slow. In contrast, reaction time did not exhibit significantly different changes over time between the two forms. These results suggest a subjectively more rapid onset of activity following sublingual compared to oral prazepam.
Researchers ; Professionals ; Students
http://hdl.handle.net/2268/249065
10.1159/000118397

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