Exosomal Long Non-Coding RNAs in Lung Diseases

[en] Within the non-coding genome landscape, long non-coding RNAs (lncRNAs) and their secretion within exosomes are a window that could further explain the regulation, the sustaining, and the spread of lung diseases. We present here a compilation of the current knowledge on lncRNAs commonly found in Chronic Obstructive Pulmonary Disease (COPD), asthma, Idiopathic Pulmonary Fibrosis (IPF), or lung cancers. We built interaction networks describing the mechanisms of action for COPD, asthma, and IPF, as well as private networks for H19, MALAT1, MEG3, FENDRR, CDKN2B-AS1, TUG1, HOTAIR, and GAS5 lncRNAs in lung cancers. We identified five signaling pathways targeted by these eight lncRNAs over the lung diseases mentioned above. These lncRNAs were involved in ten treatment resistances in lung cancers, with HOTAIR being itself described in seven resistances. Besides, five of them were previously described as promising biomarkers for the diagnosis and prognosis of asthma, COPD, and lung cancers. Additionally, we describe the exosomal-based studies on H19, MALAT1, HOTAIR, GAS5, UCA1, lnc-MMP2-2, GAPLINC, TBILA, AGAP2-AS1, and SOX2-OT. This review concludes on the need for additional studies describing the lncRNA mechanisms of action and confirming their potential as biomarkers, as well as their involvement in resistance to treatment, especially in non-cancerous lung diseases.

Research Center/Unit :

GIGA-I3 - Giga-Infection, Immunity and Inflammation - ULiège

Disciplines :

Biochemistry, biophysics & molecular biology
Genetics & genetic processes

Author, co-author :

Poulet, Christophe ; Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Service de rhumatologie

NJOCK, Makon-Sébastien ; Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Service de rhumatologie

MOERMANS, Catherine ; Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Clinique de l'asthme

LOUIS, Edouard ; Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Service de gastroentérologie, hépatologie, onco. digestive

LOUIS, Renaud ; Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Service de pneumologie - allergologie

MALAISE, Michel ; Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Service de rhumatologie

GUIOT, Julien ; Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Service de pneumologie - allergologie

Language :

English

Title :

Exosomal Long Non-Coding RNAs in Lung Diseases

Publication date :

01 May 2020

Journal title :

International Journal of Molecular Sciences

ISSN :

1661-6596

eISSN :

1422-0067

Publisher :

Multidisciplinary Digital Publishing Institute (MDPI), Switzerland

Special issue title :

The Role of Non-Coding RNAs in Human Lung Health and Disease

Volume :

Issue :

Pages :

3580

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

https://www.mdpi.com/1422-0067/21/10/3580/htm
https://www.mdpi.com/1422-0067/21/10/3580/pdf

Funders :

CHU Liège - Centre Hospitalier Universitaire de Liège [BE]

Available on ORBi :

since 29 June 2020

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