Reference : Teashirt 3 expression in the chick embryo reveals a remarkable association with tendo...
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
Life sciences : Genetics & genetic processes
Life sciences : Anatomy (cytology, histology, embryology...) & physiology
Teashirt 3 expression in the chick embryo reveals a remarkable association with tendon development
Manfroid, Isabelle mailto [Université de Liège - ULiège > Département des sciences de la vie > Biologie et génétique moléculaire >]
Caubit, Xavier [> > > >]
Marcelle, Christophe [> > > >]
Fasano, Laurent [> > > >]
Gene Expression Patterns
Elsevier Science Bv
Yes (verified by ORBi)
[en] teashirt chick ; mouse ; Drosophila ; Scleraxis ; tendon ; neurons
[en] Drosophila teashirt (tsh) is involved in the patterning of the trunk identity together with the Hox genes. In addition, it is also a player in the Wingless and the Hedgehog pathways. In birds and mammals, three Tshz genes are identified and the expression patterns for mouse Tshz1 and Tshz2 have been reported during embryogenesis. Recently, we showed that all three mouse Tshz genes can rescue the Drosophila tsh loss-of-function phenotype, indicating that the function of the teashirt genes has been conserved during evolution. Here we describe the expression pattern of chick TSHZ3 during embryogenesis. Chick TSHZ3 is expressed in several tissues including mesodermal derivatives, the central and peripheral nervous systems. Emphasis is laid on the dynamic expression occurring in regions of the somites and limbs where tendons develop. We show that TSHZ3 is activated in the somites by FGF8, a known inducer of the tendon marker SCX. (c) 2006 Elsevier B.V. All rights reserved.

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