Marqueurs diagnostiques et pronostiques de la myopathie atypique des équidés

Equine atypical myopathy is an acute environmental intoxication which results in a fatal outcome in most cases.
Veterinarians require objective criteria in order to make the right diagnosis and objectify prognosis.
The purpose of this study was to identify blood markers of interest so as to provide efficient treatment to the affected horses and to avoid the onset of clinical signs on the cograzers. The second objective was to balance the chances of success with cost management, human involvement and with animal suffering.
Parts of the data were already published, and the rest was sampled during the outbreak of cases in 2018.
The comparison between animals affected by atypical myopathy and healthy cograzers reveals significantly increased serum concentrations on sick animals of: hypoglycine A, methylenecyclopropacetyl and acylcarnitines (C2, C3, C4 et C5-carnitine). These blood markers will be included in the diagnostic process which is primary based on the medical history and the clinical signs.
The comparison between dead animals affected by atypical myopathy and survivors reveals significantly increased serum concentrations on dead animals of: C0, C2, C5 et C4 carnitine. These acylcarnitines should be used in a new algorithm for an early assessment of the survival prognosis.