Article (Scientific journals)
Controlled co‐immobilization ofbiomolecules on quinone‐bearing plasma polymer films for multifunctional biomaterial surfaces
Czuba, Urszula; Moreno-Caranjou, Maryline; Collard, Delphine et al.
2020In Plasma Processes and Polymers, 17 (11), p. 2000090
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Keywords :
coating; biomaterial; plasma; antibacterial polymer
Abstract :
[en] In this study, an efficient methodology, allowing the controlled co‐immobilization of two complementary biomolecules, is reported for the production of multifunctional antibacterial surfaces. To promote long‐lasting covalent immobilization, metallic surfaces are first coated with a quinone‐bearing poly(methacrylate)‐based thin film by combining an atmospheric pressure liquid‐assisted plasma polymerization and a controlled sodium periodate‐induced catechol oxidation steps. The influence of the oxidation step on the film morphology and chemistry is investigated using an analytical multitool approach involving atomic force microscopy, ultraviolet, infrared, and X‐ray photoelectron spectroscopy techniques. Quartz crystal microbalance with dissipation monitoring (QCM‐D) analyses allow the rapid determination of the optimal biomolecule immobilization conditions in terms of kinetics of grafting and biomolecule solution concentrations. In vitro functional assays combined with QCM‐D analyses demonstrate promising, dual biologically active coated surfaces.
Research center :
Center for Education and Research on Macromolecules (CERM)
Complex and Entangled Systems from Atoms to Materials (CESAM) Research Unit
Disciplines :
Chemistry
Materials science & engineering
Author, co-author :
Czuba, Urszula ;  University of Liège (ULiège), Complex and Entangled Systems from Atoms to Materials (CESAM) Research Unit, Center for Education and Research on Macromolecules (CERM), Belgium > Luxembourg Institute of Science and Technology (LIST), Department of Materials Research and Technology, Belvaux, Luxembourg
Moreno-Caranjou, Maryline;  Luxembourg Institute of Science and Technology (LIST), Department of Materials Research and Technology, Belvaux, Luxembourg
Collard, Delphine;  Luxembourg Institute of Science and Technology (LIST), Department of Environmental Research and Innovation, Belvaux, Luxembourg
De Pauw-Gillet, Marie-Claire;  University of Liège (ULiège), Department of Mammalian Cell Culture Laboratory–Chemistry, Belgium
Quintana, Robert;  Luxembourg Institute of Science and Technology (LIST), Department of Materials Research and Technology, Belvaux, Luxembourg
Lassaux, Patricia ;  University of Liège (ULiège), GIGA-R, Molecular Biomimetic and Protein Engineering Laboratory (MBPEL), Belgium
Detrembleur, Christophe ;  University of Liège (ULiège), Complex and Entangled Systems from Atoms to Materials (CESAM) Research Unit, Center for Education and Research on Macromolecules (CERM), Belgium
Choquet, Patrick;  Luxembourg Institute of Science and Technology (LIST), Department of Materials Research and Technology, Belvaux, Luxembourg
Language :
English
Title :
Controlled co‐immobilization ofbiomolecules on quinone‐bearing plasma polymer films for multifunctional biomaterial surfaces
Publication date :
November 2020
Journal title :
Plasma Processes and Polymers
ISSN :
1612-8850
eISSN :
1612-8869
Publisher :
Wiley - VCH Verlag GmbH & Co., Germany
Volume :
17
Issue :
11
Pages :
2000090
Peer reviewed :
Peer Reviewed verified by ORBi
Name of the research project :
METABIO project; BIOREAFILM project
Funders :
FNR - Fonds National de la Recherche [LU]
Walloon region [BE]
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
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