The impact of an ultra-trail on the dynamic of cardiac, inflammatory, renal and oxidative stress biological markers correlated with electrocardiogram and echocardiogram
LE GOFF, Caroline; Kaux, Jean-François; DULGHERU, Raluca Elenaet al.
Ultratrail; endurance; cardiac; inflammation and oxidative stress biomarkers; electrocardiogram; echocardiogram
Abstract :
[en] The aim of this study was to describe the effects of a 64.2 km ultra-trail on the biomarkers of
muscle damage, inflammation and oxidative stress, and compare the results observed with an
ECG and an echocardiogram, both performed before and after the race.
Thirty-three ultra-trail volunteers (45.8 ± 8.7 years old) were enrolled in our study. Three blood
tests were drawn from each runner, one just before (TPRE), one just after (TPOST) and the last
3 h after the end of the race (TPOST3h).
All the markers increased. The maximum concentrations observed were at TPOST3h and were
significant (p<0.001) for creatine kinase, creatine kinase isoform MB, high-sensitivity C-reactive
protein, uric acid and for the ratio of reduced glutathione to oxidised glutathione. However, in
the case of myoglobin, high-sensitive troponin T, N-terminal pro-brain natriuretic peptide, oxidised
glutathione, myeloperoxidase, cystatin C and creatinine, the most significant increases
were at TPOST (p<0.001). Modifications were observed in the medical imaging using echocardiography
such as reduction of left ventricule end-sytolic and diastolic volumes and left ventricular
global longitudinal strain. ECG showed electrical criteria for left ventricular hypertrophy and
incomplete right bundle branch block after the race.
Endurance races cause significant physiological stress to the body that can be measured by the
increase of different biomarkers. From a laboratory perspective, it is important to take into
account the possible exercise performed previous to the testing to avoid a misinterpretation of
the results. From a training perspective, due to these increases in biomarkers, it is recommended
that runners wait at least 72 h after an ultra-trail before subsequent training. In addition a transient
impairment of ventricular function due to dehydration were observed.
Disciplines :
Laboratory medicine & medical technology
Author, co-author :
LE GOFF, Caroline ; Centre Hospitalier Universitaire de Liège - CHU > Unilab > Laboratoire techniques séparatives et stress oxydant
Kaux, Jean-François ; Université de Liège - ULiège > Département des sciences de la motricité > Médecine physique, réadaptation et traumatologie du sport
DULGHERU, Raluca Elena ; Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Clinique des valvulopathies - Echocardiographies - Imagerie
SEIDEL, Laurence ; Centre Hospitalier Universitaire de Liège - CHU > Département de gestion des systèmes d'informations (GSI) > Secteur d'appui à la recherche clinique et biostatistique
PINCEMAIL, Joël ; Centre Hospitalier Universitaire de Liège - CHU > Département de chirurgie > Service de chirurgie cardio-vasculaire et thoracique
Cavalier, Etienne ; Université de Liège - ULiège > Département de pharmacie > Chimie médicale
MELON, Pierre ; Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Service de cardiologie
Language :
English
Title :
The impact of an ultra-trail on the dynamic of cardiac, inflammatory, renal and oxidative stress biological markers correlated with electrocardiogram and echocardiogram
Publication date :
September 2021
Journal title :
Acta Cardiologica
ISSN :
0001-5385
eISSN :
1784-973X
Publisher :
Association Royale des Sociétés Scientifiques Medicales Belges/Koninklijke Vereniging van de Belgische Medische Wetenschappelijke Genootschappen, Bruxelles, Belgium
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