State Analysis of Total Stressed Blood Volume and Arterial Elastance during Induced Sepsis

[en] Sepsis can cause major complications in the cardiovascular system. Accurate monitoring of model-based bio-markers, such as total stressed blood volume, SBVT , have been shown to be important parameters in determining the effectiveness of fluid therapy in sepsis patients. Another such parameter is arterial elastance, Ea, which is a measure of the relative stiffness of arteries. This work investigates the effect of fluid therapy and induced sepsis on these parameters through a state average analysis and comparison to previously defined clinical references. A three chambered lumped cardiovascular system model was implemented to develop model based analogues of the two parameters in six porcine subjects. A mean state average increase of 20.9% in SBVT was found in response to fluid therapy, while a mean state average decrease of 32.7% occurred, in surviving subjects, after sepsis was induced. Ea showed a mean state average drop of 12.2% during fluid therapy and an increase of 45% after sepsis is induced. Both results match hypothesised expectations. © 2019 IEEE.

Disciplines :

Anesthesia & intensive care

Author, co-author :

Murphy, L.; Department of Mechanical Engineering, University of Canterbury, Christchurch, New Zealand

Davidson, S.; Department of Mechanical Engineering, University of Canterbury, Christchurch, New Zealand

Knopp, J. L.; Department of Mechanical Engineering, University of Canterbury, Christchurch, New Zealand

Chase, J. G.; Department of Mechanical Engineering, University of Canterbury, Christchurch, New Zealand

Zhou, T.; Department of Mechanical Engineering, University of Canterbury, Christchurch, New Zealand

Desaive, Thomas ; Université de Liège - ULiège > Département d'astrophys., géophysique et océanographie (AGO) > Thermodynamique des phénomènes irréversibles

Language :

English

Title :

State Analysis of Total Stressed Blood Volume and Arterial Elastance during Induced Sepsis

Publication date :

2019

Event name :

41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2019

Event date :

23 July 2019 through 27 July 2019

Audience :

International

Journal title :

Annual International Conference of the IEEE Engineering in Medicine and Biology Society

ISSN :

2375-7477

eISSN :

2694-0604

Publisher :

Institute of Electrical and Electronics Engineers Inc.

Pages :

2951-2954

Peer reviewed :

Peer reviewed

Commentary :

152547 9781538613115

Available on ORBi :

since 10 June 2020

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Bibliography

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