A novel type I interferon, interferon alphaomega, shows antiviral activity against foot-and-mouth disease virus in vitro.

Li, Shifang; Gong, Meijiao; Xie, Yinli; Shao, JunJun; Zhao, FuRong; Zhang, Yongguang; Chang, Huiyun

doi:10.1016/j.micpath.2018.11.040

Article (Scientific journals)

A novel type I interferon, interferon alphaomega, shows antiviral activity against foot-and-mouth disease virus in vitro.

Li, Shifang; Gong, Meijiao; Xie, Yinli et al.

2019 • In Microbial Pathogenesis

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/248318

DOI
10.1016/j.micpath.2018.11.040

PubMed
30500407

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Keywords :

Antiviral activity;; Foot and mouth disease virus; IFN-μ; Interferon stimulated genes; PoIFN-αω; Type I interferon.

Abstract :

[en] Recently, a novel type I interferon alphaomega (IFN-αω), also known as IFN-μ, was identified. However, the biological activity of IFN-αω remain poorly understood. In this study, the porcine IFN-αω (PoIFN-αω) was expressed, purified, and its antiviral activities assessed by its ability to inhibit the cytopathic effect caused by FMDV on IBRS-2 cells. In addition, q-PCR was used to evaluate the expression of IFN-stimulated genes induced by PoIFN-αω. It was found that PoIFN-αω exerted effective antiviral activity against FMDV pre- and post-infection. Additionally, PoIFN-αω induced the transcription of IFN-stimulated genes, including Mx1, ISG15, OAS1, and PKR genes. Our study reported a new indication of PoIFN-αω as an effective anti-FMDV agent for the first time.

Disciplines :

Veterinary medicine & animal health

Author, co-author :

Li, Shifang

Gong, Meijiao ; Université de Liège - ULiège > FARAH

Xie, Yinli

Shao, JunJun

Zhao, FuRong

Zhang, Yongguang

Chang, Huiyun

Language :

English

Title :

A novel type I interferon, interferon alphaomega, shows antiviral activity against foot-and-mouth disease virus in vitro.

Publication date :

February 2019

Journal title :

Microbial Pathogenesis

ISSN :

0882-4010

eISSN :

1096-1208

Publisher :

Elsevier, Atlanta, Georgia

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 09 June 2020

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