Article (Scientific journals)
Cell stemness, epithelial-to-mesenchymal transition, and immunoevasion: Intertwined aspects in cancer metastasis.
Romano, Simona; Tufano, Martina; D'arrigo, Paolo et al.
2020In Seminars in Cancer Biology, 60, p. 181-190
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Keywords :
Cancer stemness; Immunoevasion; Mesenchymal phenotype; PD-L1
Abstract :
[en] Recent advances in tumor immunology, fostered by dramatic outcomes with cancer immunotherapy, have opened new scenarios in cancer metastasis. The cancer stemness/mesenchymal phenotype and an excess of immune suppressive signals are emerging as Intertwined aspects of human tumors. This review examines recent studies that explored the mechanistic links between cancer cell stemness and immunoevasion, and the evidence points to these key events in cancer metastasis as two sides of the same coin. This review also covers the mechanisms involved in tumor expression of programmed cell death ligand 1 (PD-L1), a major factor exploited by human neoplasias to suppress immune control. We highlight the convergence of mesenchymal traits and PD-L1 expression and examine the functions of this immune inhibitory molecule, which confers cancer cell resistance and aggressiveness.
Disciplines :
Oncology
Author, co-author :
Romano, Simona
Tufano, Martina
D'arrigo, Paolo ;  Université de Liège - ULiège > I3-Virology and Immunology
Vigorito, Vincenza
Russo, Salvatore
Romano, Maria Fiammetta
Language :
English
Title :
Cell stemness, epithelial-to-mesenchymal transition, and immunoevasion: Intertwined aspects in cancer metastasis.
Publication date :
2020
Journal title :
Seminars in Cancer Biology
ISSN :
1044-579X
eISSN :
1096-3650
Publisher :
Elsevier, Atlanta, Georgia
Volume :
60
Pages :
181-190
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
Copyright © 2019. Published by Elsevier Ltd.
Available on ORBi :
since 08 June 2020

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