Alternative macrophage polarisation associated with resistance to anti-PD1 blockade is possibly supported by the splkcing of FKBP51 immunophilin in melanoma patients
D'arrigo, Paolo ; Université de Liège - ULiège > I3-Virology and Immunology
Argenziano, Giuseppe
Ciardiello, Fortunato
Romano, Maria Fiammetta
Romano, Simona
Language :
English
Title :
Alternative macrophage polarisation associated with resistance to anti-PD1 blockade is possibly supported by the splkcing of FKBP51 immunophilin in melanoma patients
O’Donnell, J. S., Long, G. V., Scolyer, R. A., Teng, M. W. & Smyth, M. J. Resistance to PD1/PDL1 checkpoint inhibition. Cancer Treat. Rev. 52, 71–81 (2017). DOI: 10.1016/j.ctrv.2016.11.007
Sharma, P., Hu-Lieskovan, S., Wargo, J. A. & Ribas, A. Primary, adaptive, and acquired resistance to cancer immunotherapy. Cell 168, 707–723 (2017). DOI: 10.1016/j.cell.2017.01.017
Pitt, J. M., Marabelle, A., Eggermont, A., Soria, J. C., Kroemer, G. & Zitvogel, L. Targeting the tumor microenvironment: removing obstruction to anticancer immune responses and immunotherapy. Ann. Oncol. 27, 1482–1492 (2016). DOI: 10.1093/annonc/mdw168
Jacquelot, N., Roberti, M. P., Enot, D. P., Rusakiewicz, S., Ternès, N., Jegou, S. et al. Predictors of responses to immune checkpoint blockade in advanced melanoma. Nat. Commun. 8, 592 (2017). DOI: 10.1038/s41467-017-00608-2
Krieg, C., Nowicka, M., Guglietta, S., Schindler, S., Hartmann, F. J., Weber, L. M. et al. High-dimensional single-cell analysis predicts response to anti-PD-1 immunotherapy. Nat. Med. 24, 144–153 (2018). DOI: 10.1038/nm.4466
Rühle, P. F., Goerig, N., Wunderlich, R., Fietkau, R., Gaipl, U. S., Strnad, A. et al. Modulations in the peripheral immune system of glioblastoma patient is connected to therapy and tumor progression-A case report from the IMMO-GLIO-01 trial. Front. Neurol. 8, 296 (2017). DOI: 10.3389/fneur.2017.00296
Romano, S., D’Angelillo, A., Staibano, S., Simeone, E., D’Arrigo, P., Ascierto, P. A. et al. Immunomodulatory pathways regulate expression of a spliced FKBP51 isoform in lymphocytes of melanoma patients. Pigment Cell Melanoma Res. 28, 442–452 (2015). DOI: 10.1111/pcmr.12378
Baughman, G., Wiederrecht, G. J., Faith Campbell, N., Martin, M. M. & Bourgeois, S. FKBP51, a novel T-cell specific immunophilin capable of calcineurin inhibition. Mol. Cell Biol. 15, 4395–4402 (1995). DOI: 10.1128/MCB.15.8.4395
Baughman, G., Wiederrecht, G. J., Chang, F., Martin, M. M. & Bourgeois, S. Tissue distribution and abundance of human FKBP51, and FK506-binding protein that can mediate calcineurin inhibition. Biochem. Biophys Res. Commun. 232, 437–443 (1997). DOI: 10.1006/bbrc.1997.6307
Fischer, G. & Aumüller, T. Regulation of peptide bond cis/trans isomerization by enzyme catalysis and its implication in physiological processes. Rev. Physiol. Biochem. Pharmacol. 148, 105–150 (2003). DOI: 10.1007/s10254-003-0011-3
Somarelli, J. A., Lee, S. Y., Skolnick, J. & Herrera, R. J. Structure-based classification of 45 FK506-binding proteins. Proteins 72, 197–208 (2008). DOI: 10.1002/prot.21908
Romano, S., Sorrentino, A., Di Pace, A. L., Nappo, G., Mercogliano, C. & Romano, M. F. The emerging role of large immunophilin FK506 binding protein 51 in cancer. Curr. Med. Chem. 18, 5424–5429 (2011). DOI: 10.2174/092986711798194333
Bouwmeester, T., Bauch, A., Ruffner, H., Angrand, P. O., Bergamini, G., Croughton, K. et al. A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. Nat. Cell Biol. 6, 97–105 (2004). DOI: 10.1038/ncb1086
Romano, M. F., Avellino, R., Petrella, A., Bisogni, R., Romano, S. & Venuta, S. Rapamycin inhibits doxorubicin-induced NF-kappaB/Rel nuclear activity and enhances the apoptosis of melanoma cells. Eu.r J. Cancer 40, 2829–2836 (2004). DOI: 10.1016/j.ejca.2004.08.017
Romano, S., D’Angelillo, A., Pacelli, R., Staibano, S., De Luna, E., Bisogni, R. et al. Role of FK506 binding protein 51 [FKBP51] in the control of apoptosis of irradiated melanoma cells. Cell Death Differ. 17, 145–157 (2010). DOI: 10.1038/cdd.2009.115
Romano, S., Xiao, Y., Nakaya, M., D’Angelillo, A., Chang, M., Jin, J. et al. FKBP51 employs both scaffold and isomerase functions to promote NF-κB activation in melanoma. Nucleic Acids Res. 43, 6983–6993 (2015). DOI: 10.1093/nar/gkv615
Romano, S., Simeone, E., D’Angelillo, A., D’Arrigo, P., Russo, M., Capasso, M. et al. FKBP51s signature in peripheral blood mononuclear cells of melanoma patients as a possible predictive factor for immunotherapy. Cancer Immunol. Immunother. 66, 1143–1151 (2017). DOI: 10.1007/s00262-017-2004-0
Larkin, J., Chiarion-Sileni, V., Gonzalez, R., Grob, J. J., Rutkowski, P., Lao, C. D. et al. Five-year survival with combined nivolumab and ipilimumab in advanced melanoma. N. Engl. J. Med. 381, 1535–1546 (2019). DOI: 10.1056/NEJMoa1910836
Noy, R. & Pollard, J. W. Tumor-associated macrophages: from mechanisms to therapy. Immunity 41, 49–61 (2014). DOI: 10.1016/j.immuni.2014.06.010
Mantovani, A., Marchesi, F., Malesci, A., Laghi, L. & Allavena, P. Tumour-associated macrophages as treatment targets in oncology. Nat. Rev. Clin. Oncol. 14, 399–416 (2017). DOI: 10.1038/nrclinonc.2016.217
Seymour, L., Bogaerts, J., Perrone., A., Ford, R., Schwartz, L. H., Mandrekar, S. et al. iRECIST: guidelines for response criteria for use in trials testing immunotherapeutics. Lancet Oncol. 18, e143–e152 (2017). DOI: 10.1016/S1470-2045(17)30074-8
Kumar, A. P., Piedrafita, F. J. & Reynolds, W. F. Peroxisome proliferator-activated receptor gamma ligands regulate myeloperoxidase expression in macrophages by an estrogen-dependent mechanism involving the -463GA promoter polymorphism. J. Biol. Chem. 279, 8300–8315 (2004). DOI: 10.1074/jbc.M311625200
D’Arrigo, P., Russo, M., Rea, A., Tufano, M., Guadagno, E., Del Basso De Caro, M. L. et al. A regulatory role for the co-chaperone FKBP51s in PD-L1 expression in glioma. Oncotarget 8, 68291–68304 (2017). DOI: 10.18632/oncotarget.19309
Kluger, H. M., Zito, C. R., Barr, M. L., Baine, M. K., Chiang, V. L., Sznol, M. et al. Characterization of PD-L1 expression and associated T-cell infiltrates in metastatic melanoma samples from variable anatomic sites. Clin. Cancer Res. 21, 3052–3060 (2015). DOI: 10.1158/1078-0432.CCR-14-3073
Burr, M. L., Sparbier, C. E., Chan, Y. C., Williamson, J. C., Woods, K., Beavis, P. A. et al. CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity. Nature 549, 101–105 (2017). DOI: 10.1038/nature23643
Ostrand-Rosenberg, S., Horn, L. A. & Haile, S. T. The programmed death-1 immune-suppressive pathway: barrier to antitumor immunity. J. Immunol. 193, 3835–3841 (2014). DOI: 10.4049/jimmunol.1401572
Martinez, F. O., Gordon, S., Locati, M. & Mantovani, A. Transcriptional profiling of the human monocyte-to-macrophage differentiation and polarization: new molecules and patterns of gene expression. J. Immunol. 177, 7303–7311 (2006). DOI: 10.4049/jimmunol.177.10.7303
Guo, M., Härtlova, A., Gierliński, M., Prescott, A., Castellvi, J., Losa, J. H. et al. Triggering MSR1 promotes JNK-mediated inflammation in IL-4-activated macrophages. EMBO J. 38, pii:e100299 (2019). DOI: 10.15252/embj.2018100299
Zeng, H., Yang, K., Cloer, C., Neale, G., Vogel, P. & Chi, H. mTORC1 couples immune signals and metabolic programming to establish T(reg)-cell function. Nature 499, 485–490 (2013). DOI: 10.1038/nature12297
Correale, P., Rotundo, M. S., Del Vecchio, M. T., Remondo, C., Migali, C., Ginanneschi, C. et al. Regulatory (FoxP3+) T-cell tumor infiltration is a favorable prognostic factor in advanced colon cancer patients undergoing chemo or chemoimmunotherapy. J. Immunother. 33, 435–441 (2010). DOI: 10.1097/CJI.0b013e3181d32f01
Han, S., Toker, A., Liu, Z. Q. & Ohashi, P. S. Turning the tide against regulatory T cells. Front. Oncol. 9, 279 (2019). DOI: 10.3389/fonc.2019.00279