Rationale and design of the EACVI AFib Echo Europe Registry for assessing relationships of echocardiographic parameters with clinical thrombo-embolic and bleeding risk profile in non-valvular atrial fibrillation

Galderisi, M.; Donal, E.; Magne, J.; Lo Iudice, F.; Agricola, E.; Sade, L. E.; Cameli, M.; Schwammenthal, E.; Cardim, N.; Cosyns, B.; Hagendorff, A.; Neskovic, A. N.; Zamorano, J. L.; Lancellotti, Patrizio; Habib, G.; Edvardsen, T.; Popescu, B. A.

doi:10.1093/ehjci/jex322

Article (Scientific journals)

Rationale and design of the EACVI AFib Echo Europe Registry for assessing relationships of echocardiographic parameters with clinical thrombo-embolic and bleeding risk profile in non-valvular atrial fibrillation

Galderisi, M.; Donal, E.; Magne, J. et al.

2018 • In European Heart Journal. Cardiovascular Imaging, 19 (3), p. 245-252

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https://hdl.handle.net/2268/248191

DOI
10.1093/ehjci/jex322

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29474699

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Keywords :

Article; CHA2DS2-VASc score; Doppler echocardiography; Europe; HAS BLED score

Abstract :

[en] The European Society of Cardiology (ESC) guidelines for management of atrial fibrillation (AF) recommend the use of CHA 2 DS 2 VASc risk score for assessment of thromboembolic (TE) risk, whereas the stratification of bleeding risk should be obtained by HAS-Bleed to balance the most appropriate anticoagulation (OAC) therapy. However, men with CHA 2 DS 2 VASc score = 1 and women with CHA 2 DS 2 VASc = 2, who are at intermediate TE risk, represent a grey zone where guidelines do not provide a definite OAC indication. Accordingly, implementation of risk stratification with echocardiography could be extremely useful. Both prospective and cross-sectional studies on transthoracic echocardiography (TTE) prediction of TE events and studies utilizing transoesophageal echocardiographic parameters as surrogate markers of TE events makes sustainable the hypothesis that echocardiography could improve TE prediction in non-valvular AF. Moreover, considering the close association of AF and stroke, all echo-Doppler parameters that have shown to predict AF onset and recurrence could be useful also to predict TE events in this clinical setting. Accordingly, EACVI AFib Echo Europe Registry has been designed as an observational, cross-sectional study, with the aim of evaluating: (i) left atrial (LA) size and function together with left ventricular geometry, systolic and diastolic functions in paroxysmal, persistent, and permanent AF; (ii) relationships of structural/functional parameters with clinical TE and bleeding risk profile. By the AFib Echo Europe Registry, we expect to collect data on echocardiographic phenotype of patients with AF. The large data set accumulated will be useful to test the level of agreement of different echocardiographic measurements with the available risk scores. © 2017 The Author.

Disciplines :

Cardiovascular & respiratory systems

Author, co-author :

Galderisi, M.; Department of Advanced Biomedical Sciences, Federico II University Hospital, via S. Pansini 5, Naples, Italy

Donal, E.; CHU Rennes, Service de Cardiologie et Maladies Vasculaires, Université Rennes, 2 rue Henri Le Guilloux, Rennes, France

Magne, J.; Service Cardiologie, CHU Limoges, Hospital Dupuytren, 2, avenue Martin Luther King, Limoges, France

Lo Iudice, F.; Department of Advanced Biomedical Sciences, Federico II University Hospital, via S. Pansini 5, Naples, Italy

Agricola, E.; Cardiothoracic Department, Echocardiography Laboratory, Clinical Cardiology Unit, San Raffaele Hospital of Milan (IRCCS), via Olgettina 60, Milano, Italy

Sade, L. E.; Department of Cardiology, Baskent University, Faculty of Medicine, Fevzi okmak Cad. 10. Sok. Bahcelievler, Ankara, Turkey

Cameli, M.; Department of Cardiovascular Diseases, University of Siena, Policlinico S. Maria Alle Scotte, Viale M. Bracci, 16, Siena, Italy

Schwammenthal, E.; Department of Cardiology, Heart Center, Sheba Medical Center, Sackler School of Medicine, Tel Aviv University, Emek HaEla St 1, Ramat Gan, Israel

Cardim, N.; Cardiac Imaging Department, Hospital da Luz, Av. Lusíada 100, Lisbon, Portugal

Cosyns, B.; CHVZ (Centrum voor Hart en Vaatziekten), Universitair Ziekenhuis and ICMI, In Vivo Cellular and Molecular Imaging) Laboratory, 101 Laarbeeklaan, Jette, Brussels, Belgium

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Language :

English

Title :

Publication date :

2018

Journal title :

European Heart Journal. Cardiovascular Imaging

ISSN :

2047-2404

eISSN :

2047-2412

Publisher :

Oxford University Press

Volume :

Issue :

Pages :

245-252

Peer reviewed :

Peer Reviewed verified by ORBi

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since 08 June 2020

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