Model-based Modified OGTT Insulin Sensitivity Test Design

OGTT; Blood; Diagnosis; Glucose; Insulin; Testing; Blood glucose level; Diabetes care; Efficient monitoring; Emerging technologies; Insulin sensitivity; Quantitative tests; Type 2 diabetes mellitus; Physiological models

Abstract :

[en] Type 2 diabetes mellitus requires early, accurate, and efficient monitoring for best treatment. Current common diagnosis tools either test late-appearing symptoms, are low resolution, or are expensive in cost and time. A system of physiological models for the oral ingestion of glucose, subcutaneous injection of insulin, and glycaemic control, are used to generate a quantitative test for insulin sensitivity. The proposed test uses 35g of oral glucose, 2.0 units of rapid-acting insulin, and both intra-venous and finger-prick blood samples for insulin, C-peptides, and blood glucose levels frequently over a 2-hour period. The test is developed in silico to enable early and repetitive monitoring of the pathogenesis of type 2 diabetes. In conjunction with emerging technologies in insulin sensing and needle-free delivery and monitoring devices, there is a pathway with this test to provide more effective, efficient early diagnosis of diabetes risk. © 2018

Disciplines :

Anesthesia & intensive care

Author, co-author :

Holder-Pearson, L.; Centre for Bio-Engineering, University of Canterbury, Christchurch, New Zealand

Bekisz, Sophie ; Université de Liège - ULiège > Département d'aérospatiale et mécanique > Génie biomécanique

Knopp, J.; Centre for Bio-Engineering, University of Canterbury, Christchurch, New Zealand

Docherty, P.; Centre for Bio-Engineering, University of Canterbury, Christchurch, New Zealand

Chase, J. G.; Centre for Bio-Engineering, University of Canterbury, Christchurch, New Zealand

Desaive, Thomas ; Université de Liège - ULiège > Département d'astrophys., géophysique et océanographie (AGO) > Thermodynamique des phénomènes irréversibles

Language :

English

Title :

Model-based Modified OGTT Insulin Sensitivity Test Design

Publication date :

2018

Event name :

BMS 2018

Event date :

3-5 septembre 2018

By request :

Yes

Audience :

International

Journal title :

IFAC-PapersOnLine

ISSN :

2405-8971

eISSN :

2405-8963

Publisher :

Elsevier B.V.

Volume :

Issue :

Pages :

86-91

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 05 June 2020

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Bibliography

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