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Model-based Modified OGTT Insulin Sensitivity Test Design
Holder-Pearson, L.; Bekisz, Sophie; Knopp, J. et al.
2018In IFAC-PapersOnLine, 51 (27), p. 86-91
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Keywords :
OGTT; Blood; Diagnosis; Glucose; Insulin; Testing; Blood glucose level; Diabetes care; Efficient monitoring; Emerging technologies; Insulin sensitivity; Quantitative tests; Type 2 diabetes mellitus; Physiological models
Abstract :
[en] Type 2 diabetes mellitus requires early, accurate, and efficient monitoring for best treatment. Current common diagnosis tools either test late-appearing symptoms, are low resolution, or are expensive in cost and time. A system of physiological models for the oral ingestion of glucose, subcutaneous injection of insulin, and glycaemic control, are used to generate a quantitative test for insulin sensitivity. The proposed test uses 35g of oral glucose, 2.0 units of rapid-acting insulin, and both intra-venous and finger-prick blood samples for insulin, C-peptides, and blood glucose levels frequently over a 2-hour period. The test is developed in silico to enable early and repetitive monitoring of the pathogenesis of type 2 diabetes. In conjunction with emerging technologies in insulin sensing and needle-free delivery and monitoring devices, there is a pathway with this test to provide more effective, efficient early diagnosis of diabetes risk. © 2018
Disciplines :
Anesthesia & intensive care
Author, co-author :
Holder-Pearson, L.;  Centre for Bio-Engineering, University of Canterbury, Christchurch, New Zealand
Bekisz, Sophie  ;  Université de Liège - ULiège > Département d'aérospatiale et mécanique > Génie biomécanique
Knopp, J.;  Centre for Bio-Engineering, University of Canterbury, Christchurch, New Zealand
Docherty, P.;  Centre for Bio-Engineering, University of Canterbury, Christchurch, New Zealand
Chase, J. G.;  Centre for Bio-Engineering, University of Canterbury, Christchurch, New Zealand
Desaive, Thomas  ;  Université de Liège - ULiège > Département d'astrophys., géophysique et océanographie (AGO) > Thermodynamique des phénomènes irréversibles
Language :
English
Title :
Model-based Modified OGTT Insulin Sensitivity Test Design
Publication date :
2018
Event name :
BMS 2018
Event date :
3-5 septembre 2018
By request :
Yes
Audience :
International
Journal title :
IFAC-PapersOnLine
ISSN :
2405-8971
eISSN :
2405-8963
Publisher :
Elsevier B.V.
Volume :
51
Issue :
27
Pages :
86-91
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 05 June 2020

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