Article (Scientific journals)
Protein translation and psychiatric disorders
Laguesse, Sophie; Ron, Dorit
2020In Neuroscientist, 26 (1), p. 21-42
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Keywords :
addiction; bipolar disorder; mRNA translation; maor depressive disorder; protein translation; psychiatric disorders
Abstract :
[en] Although historically research has focused on transcription as the central governor of protein expression, protein translation is now increasingly being recognized as a major factor for determining protein levels within cells. The central nervous system relies on efficient updating of the protein landscape. Thus, coordinated regulation of mRNA localization, initiation, or termination of translation is essential for proper brain function. In particular, dendritic protein synthesis plays a key role in synaptic plasticity underlying learning and memory as well as cognitive processes. Increasing evidence suggests that impaired mRNA translation is a common feature found in numerous psychiatric disorders. In this review, we describe how malfunction of translation contributes to development of psychiatric diseases, including schizophrenia, major depression, bipolar disorder, and addiction.
Research center :
Department of Neurology, University of San Francisco, CA US
Giga-Neurosciences - ULiège
Giga-Development and Stem Cells - ULiège
Disciplines :
Neurology
Author, co-author :
Laguesse, Sophie  ;  Université de Liège - ULiège > Stem Cells-Molecular Regulation of Neurogenesis
Ron, Dorit
Language :
English
Title :
Protein translation and psychiatric disorders
Publication date :
February 2020
Journal title :
Neuroscientist
ISSN :
1073-8584
eISSN :
1089-4098
Publisher :
SAGE Science Press, United States - California
Volume :
26
Issue :
1
Pages :
21-42
Peer reviewed :
Peer Reviewed verified by ORBi
European Projects :
H2020 - 839178 - ALCO-ADO - Unveiling the alcohol-dependent alterations in local dendritic translation of mRNAs in the prefrontal cortex during adolescence
Funders :
NIAAA - National Institute on Alcohol Abuse and Alcoholism
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
H2020
Fonds Léon Fredericq [BE]
CE - Commission Européenne [BE]
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