Reference : Three-dimensional printing technology as a promising tool in bioavailability enhancem...
Scientific journals : Article
Human health sciences : Pharmacy, pharmacology & toxicology
http://hdl.handle.net/2268/245825
Three-dimensional printing technology as a promising tool in bioavailability enhancement of poorly water-soluble molecules: a review
English
Jennotte, Olivier mailto [Université de Liège - ULiège > Département de pharmacie > Pharmacie galénique >]
Koch, Nathan mailto [Université de Liège - ULiège > Département de pharmacie > Pharmacie galénique >]
Lechanteur, Anna mailto [Université de Liège - ULiège > Département de pharmacie > Pharmacie galénique >]
Evrard, Brigitte mailto [Université de Liège - ULiège > Département de pharmacie > Pharmacie galénique >]
2020
International Journal of Pharmaceutics
Elsevier
Yes (verified by ORBi)
International
0378-5173
1873-3476
Netherlands
[en] Three-dimensional printing ; aqueous soluiblity enhancement ; drug delivrey systems
[en] Poor aqueous solubility of active pharmaceutical ingredients (API) is nowadays a major issue in the pharmaceutical field. The combinatorial chemistry provides more and more API with a great therapeutic potential, but with a low aqueous solubility. Among the strategies to overcome this drawback, the use of amorphous solid dispersions (ASD), as well as the increase of surface area, is widely used. The three dimensional (3D) printing technologies appear to be innovative tools allowing the construction of any unconventional forms with different composition, structure or infill; especially by using ASD materials. This review aims to deliver notions about the different 3D printing techniques found in the literature to improve aqueous solubility of several API, namely nozzle-based method, inkjet methods and laser-based methods, as well as guide formulator in terms of formulation parameters that have to be optimized to allow the most suitable impression of innovative medicines.
Centre Interdisciplinaire de Recherche sur le Médicament - CIRM
http://hdl.handle.net/2268/245825
10.1016/j.ijpharm.2020.119200

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