Article (Scientific journals)
Three-dimensional printing technology as a promising tool in bioavailability enhancement of poorly water-soluble molecules: a review
Jennotte, Olivier; Koch, Nathan; Lechanteur, Anna et al.
2020In International Journal of Pharmaceutics
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Keywords :
Three-dimensional printing; aqueous soluiblity enhancement; drug delivrey systems
Abstract :
[en] Poor aqueous solubility of active pharmaceutical ingredients (API) is nowadays a major issue in the pharmaceutical field. The combinatorial chemistry provides more and more API with a great therapeutic potential, but with a low aqueous solubility. Among the strategies to overcome this drawback, the use of amorphous solid dispersions (ASD), as well as the increase of surface area, is widely used. The three dimensional (3D) printing technologies appear to be innovative tools allowing the construction of any unconventional forms with different composition, structure or infill; especially by using ASD materials. This review aims to deliver notions about the different 3D printing techniques found in the literature to improve aqueous solubility of several API, namely nozzle-based method, inkjet methods and laser-based methods, as well as guide formulator in terms of formulation parameters that have to be optimized to allow the most suitable impression of innovative medicines.
Research center :
CIRM - Centre Interdisciplinaire de Recherche sur le Médicament - ULiège
Disciplines :
Pharmacy, pharmacology & toxicology
Author, co-author :
Jennotte, Olivier ;  Université de Liège - ULiège > Département de pharmacie > Pharmacie galénique
Koch, Nathan ;  Université de Liège - ULiège > Département de pharmacie > Pharmacie galénique
Lechanteur, Anna  ;  Université de Liège - ULiège > Département de pharmacie > Pharmacie galénique
Evrard, Brigitte  ;  Université de Liège - ULiège > Département de pharmacie > Pharmacie galénique
Language :
English
Title :
Three-dimensional printing technology as a promising tool in bioavailability enhancement of poorly water-soluble molecules: a review
Publication date :
2020
Journal title :
International Journal of Pharmaceutics
ISSN :
0378-5173
eISSN :
1873-3476
Publisher :
Elsevier, Netherlands
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 09 March 2020

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