Unpublished conference/Abstract (Scientific congresses and symposiums)
Characterization of the treatment trajectory and assessment of the disease weight during uncomplicated malaria in the Democratic Republic of Congo
KAYIBA, Nadine; YOBI, Doudou; Devleesschauwer, Bart et al.
2019European Congress on Tropical Medicine and International Health (ECTMIH)
 

Files


Full Text
Abstract.docx
Publisher postprint (13.9 kB)
Download

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
Malaria; PfK13; RDC; Resistance
Abstract :
[en] Introduction: The emergence of Plasmodium falciparum (Pf) resistance to artemisinin (PfART-R) in Africa is a worrisome situation that would annihilate the progress made in reducing the global burden of malaria. The discovery of mutations occurring in portions of the Pf gene sequence encoding kelch 13 (PfK13) – propeller domain and inducing PfART-R, has provided unprecedented opportunities for monitoring such resistance at large scale. Aim: This study aimed to review the PfK13 allelic polymorphism and its spatial distribution in Africa for drawing a baseline for subsequent epidemiological surveillance and containment efforts of PfART-R. Methods: A systematic review was performed according to PRISMA guidelines through six electronic databases consulted up to December 2018. Studies assessing the PfK13 gene in any of the 54 African countries were explored and data related to individual single nucleotide polymorphisms from each report and sampling location were geo-referenced and locus-referenced to be uploaded on maps displaying spatial and molecular patterns. Results: From 8,678 screened records, 50 reports were identified as eligible providing 22,739 Pf isolates successfully sequenced for the PfK13 and originating from 109 sites surveyed in 41 African countries. Overall 619 nonsynonymous (NS) mutants (2.7% of sequenced isolates) were reported at varied relative frequencies (0.5 to 50%) most often being K189T and A578S.Intermediate proportions (30 to 50%) of NS mutants were found in Western and Eastern Africa, moderate proportions (10 to 20%) in Middle Africa and low to very low proportions (<5%), elsewhere. NS mutations were not detected in 11 of 41 sampling countries. A total of 8 PfK13 NS mutations (F446I, C469Y, R515K, S522C, P553L, V568G, P574L, and A675V) out of 24 known as “associated molecular markers” for PfART-R were noticed at relative frequencies from 0.08 to 10.2%. One NS mutation (M476I) out of 6 established as “validated molecular markers” for PfART-R was reported at a relative frequency of 0.42%. Possible foci of NS mutations were noticed in Eastern, Western, and Middle Africa. Conclusion: Africa has noticed rare but alarming signals of possible emergence of Pf-ART-R. Proactive surveillance strategies are needed to be established in different African regions to refrain from massive development of resistance.
Disciplines :
Public health, health care sciences & services
Immunology & infectious disease
Author, co-author :
KAYIBA, Nadine
YOBI, Doudou
Devleesschauwer, Bart
Mvumbi, Dieudonné
Kabututu, Pius
Okitolonda, Wemakoy
Likwela, Joris
De Mol, Patrick ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Département des sciences biomédicales et précliniques
Hayette, Marie-Pierre ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Bactériologie, mycologie, parasitologie, virologie
Mvumbi, Georges
Beutels, P
Rosas-Aguirre, Angel
Speybroeck, Niko
More authors (3 more) Less
Language :
English
Title :
Characterization of the treatment trajectory and assessment of the disease weight during uncomplicated malaria in the Democratic Republic of Congo
Alternative titles :
[en] Caractérisation du trajectoire et évaluation du poids de la maladie durant la malaria non compliquée en RDC
Publication date :
September 2019
Event name :
European Congress on Tropical Medicine and International Health (ECTMIH)
Event place :
LIVERPOOL, United Kingdom
Event date :
16-20 September 2019
Audience :
International
Available on ORBi :
since 23 February 2020

Statistics


Number of views
71 (2 by ULiège)
Number of downloads
5 (0 by ULiège)

Bibliography


Similar publications



Contact ORBi