Article (Scientific journals)
Acute myocardiotoxicity during 5-fluorouracil therapy.
Misset, Benoît; Escudier, Bernard; Leclercq, Bernard et al.
1990In Intensive Care Medicine, 16 (3), p. 210-1
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Keywords :
Adult; Cardiomyopathies/chemically induced/complications/diagnosis; Colonic Neoplasms/drug therapy; Fluorouracil/administration & dosage/adverse effects/therapeutic use; Hemodynamics; Humans; Infusions, Intravenous; Male; Shock, Cardiogenic/etiology/physiopathology
Abstract :
[en] A 38-year-old man with a colonic carcinoma experienced cardiogenic shock during continuous intravenous treatment with 5-fluorouracil (5-FU), without clinical or electrical signs of coronary insufficiency and with a normal coronary angiogram. His symptoms resolved after eight days of inotropic and vasodilator therapy. Because of the severity of the shock, rechallenge was not performed. This is the first case of acute cardiac failure without coronary ischemia, associated with 5-FU monotherapy. Experimental studies suggest that this adverse effect could be due to myocardial accumulation of 5-FU leading to depletion of high energy phosphate compounds. This might also explain the more frequently seen acute coronary insufficiency due to 5-FU.
Disciplines :
Anesthesia & intensive care
Author, co-author :
Misset, Benoît ;  Centre Hospitalier Universitaire de Liège - CHU > Autres Services Médicaux > Service des soins intensifs
Escudier, Bernard
Leclercq, Bernard
Rivara, Daniel
Rougier, Philippe
Nitenberg, Gérard
Language :
English
Title :
Acute myocardiotoxicity during 5-fluorouracil therapy.
Publication date :
1990
Journal title :
Intensive Care Medicine
ISSN :
0342-4642
eISSN :
1432-1238
Publisher :
Springer, Heidelberg, Germany
Volume :
16
Issue :
3
Pages :
210-1
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 21 February 2020

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