Article (Scientific journals)
Novel insights into parathyroid hormone: report of The Parathyroid Day in Chronic Kidney Disease.
Urena-Torres, Pablo A.; Vervloet, Marc; Mazzaferro, Sandro et al.
2019In Clinical Kidney Journal, 12 (2), p. 269-280
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Keywords :
CKD; calcium; hyperparathyroidism; phosphataemia; vitamin D
Abstract :
[en] Chronic kidney disease (CKD) is often associated with a mineral and bone disorder globally described as CKD-Mineral and Bone Disease (MBD), including renal osteodystrophy, the latter ranging from high bone turnover, as in case of secondary hyperparathyroidism (SHPT), to low bone turnover. The present article summarizes the important subjects that were covered during 'The Parathyroid Day in Chronic Kidney Disease' CME course organized in Paris in September 2017. It includes the latest insights on parathyroid gland growth, parathyroid hormone (PTH) synthesis, secretion and regulation by the calcium-sensing receptor, vitamin D receptor and fibroblast growth factor 23 (FGF23)-Klotho axis, as well as on parathyroid glands imaging. The skeletal action of PTH in early CKD stages to the steadily increasing activation of the often downregulated PTH receptor type 1 has been critically reviewed, emphasizing that therapeutic strategies to decrease PTH levels at these stages might not be recommended. The effects of PTH on the central nervous system, in particular cognitive functions, and on the cardiovascular system are revised, and the reliability and exchangeability of second- and third-generation PTH immunoassays discussed. The article also reviews the different circulating biomarkers used for the diagnosis and monitoring of CKD-MBD, including PTH and alkaline phosphatases isoforms. Moreover, it presents an update on the control of SHPT by vitamin D compounds, old and new calcimimetics, and parathyroidectomy. Finally, it covers the latest insights on the persistence and de novo occurrence of SHPT in renal transplant recipients.
Disciplines :
Urology & nephrology
Laboratory medicine & medical technology
Author, co-author :
Urena-Torres, Pablo A.
Vervloet, Marc
Mazzaferro, Sandro
Oury, Franck
Brandenburg, Vincent
Bover, Jordi
Cavalier, Etienne  ;  Université de Liège - ULiège > Département de pharmacie > Chimie médicale
Cohen-Solal, Martine
Covic, Adrian
Drueke, Tilman B.
Hindie, Elif
Evenepoel, Pieter
Frazao, Joao
Goldsmith, David
Kazama, Junichiro James
Cozzolino, Mario
Massy, Ziad A.
More authors (7 more) Less
Language :
English
Title :
Novel insights into parathyroid hormone: report of The Parathyroid Day in Chronic Kidney Disease.
Publication date :
2019
Journal title :
Clinical Kidney Journal
ISSN :
2048-8505
eISSN :
2048-8513
Publisher :
Oxford University Press, United Kingdom
Volume :
12
Issue :
2
Pages :
269-280
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 13 February 2020

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