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Biochemistry of thiamine and thiamine phosphate compounds
Bettendorff, Lucien; Wins, Pierre
2021In Jez, Joseph (Ed.) Encyclopedia of Biological Chemistry, 3rd Edition, vol 1
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Keywords :
Thiamine; Alcohol; Wernicke-Korsakoff syndrome; Krebs cycle; Transketolase; Oxidative metabolism; Non-cofactor role
Abstract :
[en] Thiamine (vitamin B1) is an essential molecule for all living organisms. It is the precursor for several phosphorylated derivatives, the most important being the coenzyme thiamine diphosphate (ThDP). Thiamine is transported into cells by specific transporters and pyrophosphorylated to ThDP in the cytosol. ThDP is an essential cofactor for cellular oxidative energy metabolism. Thiamine deficiency disorders lead to severe nervous system lesion and cardiac failure. ThDP is the precursor for two triphosphorylated derivatives, thiamine triphosphate and adenosine thiamine triphosphate, with unknown function but present in all three kingdoms of life.
Research center :
Giga-Neurosciences - ULiège
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Bettendorff, Lucien  ;  Université de Liège - ULiège > Neurosciences-Neurophysiology
Wins, Pierre ;  Université de Liège - ULiège > Département des sciences cliniques > Département des sciences cliniques
Language :
English
Title :
Biochemistry of thiamine and thiamine phosphate compounds
Publication date :
2021
Main work title :
Encyclopedia of Biological Chemistry, 3rd Edition, vol 1
Editor :
Jez, Joseph
Publisher :
Elsevier
ISBN/EAN :
9780128194607
Pages :
302-313
Peer reviewed :
Peer reviewed
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
Available on ORBi :
since 10 February 2020

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