Biochemistry of thiamine and thiamine phosphate compounds

[en] Thiamine (vitamin B1) is an essential molecule for all living organisms. It is the precursor for several phosphorylated derivatives, the most important being the coenzyme thiamine diphosphate (ThDP). Thiamine is transported into cells by specific transporters and pyrophosphorylated to ThDP in the cytosol. ThDP is an essential cofactor for cellular oxidative energy metabolism. Thiamine deficiency disorders lead to severe nervous system lesion and cardiac failure. ThDP is the precursor for two triphosphorylated derivatives, thiamine triphosphate and adenosine thiamine triphosphate, with unknown function but present in all three kingdoms of life.

Research Center/Unit :

Giga-Neurosciences - ULiège

Disciplines :

Biochemistry, biophysics & molecular biology

Author, co-author :

Bettendorff, Lucien ; Université de Liège - ULiège > Neurosciences-Neurophysiology

Wins, Pierre ; Université de Liège - ULiège > Département des sciences cliniques > Département des sciences cliniques

Language :

English

Title :

Biochemistry of thiamine and thiamine phosphate compounds

Publication date :

2021

Main work title :

Encyclopedia of Biological Chemistry, 3rd Edition, vol 1

Editor :

Jez, Joseph

Publisher :

Elsevier

ISBN/EAN :

9780128194607

Pages :

302-313

Peer reviewed :

Peer reviewed

Funders :

F.R.S.-FNRS - Fonds de la Recherche Scientifique

Available on ORBi :

since 10 February 2020

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