Article (Scientific journals)
Mesenchymal Stromal Cells in Solid Organ Transplantation.
VANDERMEULEN, Morgan; ERPICUM, Pauline; WEEKERS, Laurent et al.
2020In Transplantation, 104 (5), p. 923-936
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Abstract :
[en] Over the past decade, the clinical application of mesenchymal stromal cells (MSCs) has generated growing enthusiasm as an innovative cell-based approach in solid organ transplantation (SOT). These expectations arise from a significant number of both transplant- and non-transplant-related experimental studies investigating the complex anti-inflammatory, immunomodulatory and tissue-repair properties of MSCs. Promising preclinical results have prompted clinical trials using MSC-based therapy in SOT. In the present review, the general properties of MSCs are summarized, with a particular emphasis on MSC-mediated impact on the immune system and in the ischemic conditioning strategy. Next, we chronologically detail all clinical trials using MSCs in the field of SOT. Finally, we envision the challenges and perspectives of MSC-based cell therapy in SOT.
Disciplines :
Surgery
Urology & nephrology
Author, co-author :
VANDERMEULEN, Morgan ;  Centre Hospitalier Universitaire de Liège - CHU > Département de chirurgie > Chirurgie abdo, sénologique, endocrine et de transplantation
ERPICUM, Pauline 
WEEKERS, Laurent  
BRIQUET, Alexandra 
LECHANTEUR, Chantal 
Detry, Olivier  ;  Université de Liège - ULiège > Département des sciences cliniques > Pathologie chirurgicale abdominale et endocrinienne
Beguin, Yves  ;  Université de Liège - ULiège > Département des sciences cliniques > Hématologie
Jouret, François  ;  Université de Liège - ULiège > Cardiovascular Sc.-Lab. of Translational Res. in Nephrology
Language :
English
Title :
Mesenchymal Stromal Cells in Solid Organ Transplantation.
Publication date :
May 2020
Journal title :
Transplantation
ISSN :
0041-1337
eISSN :
1534-6080
Publisher :
Lippincott Williams & Wilkins, United States - Maryland
Volume :
104
Issue :
5
Pages :
923-936
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 21 January 2020

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