Hematopoietic stem cell transplantation with unrelated cord blood or haploidentical donor grafts in adult patients with secondary acute myeloid leukemia, a comparative study from Eurocord and the ALWP EBMT

Ruggeri, A.; Labopin, M.; Savani, B.; Paviglianiti, A.; Blaise, D.; Volt, F.; Ciceri, F.; Bacigalupo, A.; Tischer, J.; Chevallier, P.; Koc, Y.; Cornelissen, J. J.; Ehninger, G.; Sanz, G.; Deconinck, E.; Rocha, V.; Baron, Frédéric; Mohty, M.; Gluckman, E.; Nagler, A.

doi:10.1038/s41409-019-0582-5

Article (Scientific journals)

Hematopoietic stem cell transplantation with unrelated cord blood or haploidentical donor grafts in adult patients with secondary acute myeloid leukemia, a comparative study from Eurocord and the ALWP EBMT

Ruggeri, A.; Labopin, M.; Savani, B. et al.

2019 • In Bone Marrow Transplantation, 54, p. 1987-1994

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https://hdl.handle.net/2268/243671

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10.1038/s41409-019-0582-5

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31150016

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Abstract :

[en] Survival of patients with secondary acute myeloid leukemia (sAML) is poor. Cord blood transplantation (UCBT) and non-T-cell-depleted stem cell transplantation from haploidentical donors (HAPLO) are both strategies that have shown encouraging results in patients who do not have an human leukocyte antigen (HLA)-matched sibling or unrelated donor. We retrospectively analyzed outcomes of 409 adults with sAML receiving either UCBT (n = 163) or HAPLO (n = 246) in EBMT centers. Myelodysplastic syndrome (MDS) or myeloproliferative disorder (MPD) was the antecedent diagnosis in 79% of UCBT and 85% of HAPLO recipients. In multivariate analysis, UCBT was associated with higher risk of grade II–IV acute GVHD (HR 1.9, p = 0.009) and lower GHVD-free-relapse-free-survival (GRFS) (HR 1.57, p = 0.007) compared to HAPLO. Chronic-GVHD, RI, NRM, LFS, and OS were not statistically different between the two. Early disease stage at transplant was independently associated with lower RI and NRM and higher OS and LFS. These results indicate that HAPLO is associated with better GRFS and lower aGvHD compared to UCBT in patients with sAML and that UCBT can be a valid alternative for sAML patients who lack a matched sibling, a proper haploidentical or an unrelated donor. © 2019, The Author(s), under exclusive licence to Springer Nature Limited.

Disciplines :

Hematology

Author, co-author :

Ruggeri, A.; Department of Pediatric Hematology and Oncology, IRCCS Bambino Gesù Children’s Hospital, Piazza S.Onofrio, 4, Roma, 00165, Italy

Labopin, M.; Hôpital Saint Antoine, Service d’Hématologie et Thérapie Cellulaire, AP-HP, Paris, France

Savani, B.; Vanderbilt University Medical Center, Nashville, TN, United States

Paviglianiti, A.; Hôpital Saint Antoine, Service d’Hématologie et Thérapie Cellulaire, AP-HP, Paris, France

Blaise, D.; Institut Paoli Calmettes, Marseille, France

Volt, F.; Hôpital Saint Louis, Eurocord, IUH University Paris VII, Paris, France, Monacord, Centre Scientifique de Monaco, Monaco

Ciceri, F.; Hematology and BMT Unit, San Raffaele Scientific Institute, Milano, Italy

Bacigalupo, A.; Hematology Department, Fondazione Policlinico Universitario Agostino Gemelli, Universita’ Cattolica deI Sacro Cuore, Rome, Italy

Tischer, J.; Ludwig Maximilian University Hospital of Munich, Munich, Germany

Chevallier, P.; Service d’hématologie, Hôtel Dieu, Nantes, France

More authors (10 more)

Language :

English

Title :

Publication date :

2019

Journal title :

Bone Marrow Transplantation

ISSN :

0268-3369

eISSN :

1476-5365

Publisher :

Nature Publishing Group

Volume :

Pages :

1987-1994

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 21 January 2020

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